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Biomedical subjects

U F Haustein

Publications and source records attributed to U F Haustein.

At least 181 records · Page 10Linked to original sources
PubMed1986

Irritant potential of dithranol.

The minimal irritation dose (MID) for dithranol in 5% salicylic acid vaseline was determined by open patch testing. From the MID, the irritation dose 50 (ID50) was evaluated. It was 0.057% in 100 controls and 0.046% in 100 psoriatic patients, which is not statistically different due to the great differences between individuals. 20 other patients claimed a dithranol hyperreactivity in their history. Only 13 of them, however, showed a decrease in the MID, which was between 0.01 and 0.02% (means = 0.014%), i.e. outside the confidence interval found in the 100 psoriatic patients. 8 of these 13 reacted with blister formation after exposure to 0.1-0.16% dithranol. An allergic contact dermatitis was excluded as the cause of the hyperreactivity. The tolerance to increasing dithranol concentrations after beginning with the MID up to clearance of the lesions, as well as the predominance of granulocytes as compared to lymphocytes in blisters due to dithranol testing, suggest an irritant inflammatory mechanism. In such hyperreactive cases therapy should be started with the MID established in the open patch test.

Anthralin↗
PubMed1986

[Histamine reactivity of affected and unaffected skin in endogenous eczema and in chronic allergic contact dermatitis].

In 30 patients with atopic dermatitis and 40 with allergic contact dermatitis in the chronic stage intracutaneous tests were performed with 0.1 ml histamine 1:10,000 in affected and non-affected skin. The erythematous and wheal reactions were compared with 40 age- and sex-matched controls. The diameters of the erythema and wheals were significantly reduced in affected and non-affected skin of the atopic dermatitis (p less than 0.01). In allergic contact dermatitis only the erythema of the affected and non-affected skin was reduced (p less than 0.05), but not the wheal reaction. The erythematous reaction was, however, less reduced in non-affected skin than in the affected one of the allergic contact dermatitis (p less than 0.05). The reduced histamine reactivity seems to be a typical basic mechanism in atopic dermatitis. It is suggested to be due to the histamine mediated immune modulation and the increased release from mast cells, leading to a refractory behaviour of histamine receptors of the blood vessels like in tachyphylaxis. It is interpreted as a secondary phenomenon in allergic contact dermatitis. Although the histamine reaction shows differences for the groups of patients, it is not suitable to discriminate single cases.

Dermatitis↗
PubMed1985

Allergic and irritant potential of benzoyl peroxide.

Benzoyl peroxide (BP) is shown to be a weak allergen. Of 25 guinea pigs, only 5 were sensitized in the TINA test. Before treatment, only 2 of 172 acne patients gave a positive patch test with 1% BP, but not with 0.1% BP. The following results suggest that BP is a strong irritant. The irritant potential ID50 in rabbits was 2.52%, and the IT50 was 2.31 days with 5% BP, 4.34 days with 1% and 8.35 days with 0.1% BP. 29% of acne patients and non-exposed controls had a positive patch test with 5% BP. However, only 11 of 155 acne patients had clinical signs of intolerance, which settled despite continued use in 10 cases. The possible reasons for this dichotomy are explored. Neither the irritant nor allergenic properties of BP impaired its clinical use.

Acne Vulgaris↗