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Biomedical subjects

U Förster

Publications and source records attributed to U Förster.

At least 19 recordsLinked to original sources
PubMed2006

[Neuroendocrine tumors of the larynx].

BACKGROUND: The location of neuroendocrine tumors in the larynx (NETL) is atypical and relatively rare. It has become possible to determine increasing numbers of these tumors in recent years owing to improvements in immunohistological methods. Extensive recommendations were made with regard to diagnostics and treatment by the "European Neuroendocrine Tumor Group" in 2004. These recommendations relate mainly to the very much more frequent gastroenteropancreatic neuroendocrine tumors and cannot be applied directly to NET of the larynx. This is why precise scientific investigations of NETL and publications of new cases are important. METHODS: Retrospective review of all laryngeal malignancies treated from 1994 to 2004 revealed a NETL in three of about 1000 patients. These patients were evaluated with regard to clinical symptoms, tumor locations, immunohistological findings and the clinical courses. RESULTS: Evaluation of the patients (incidence 0.23%: average age 58 years: female to male 1:2) revealed a poorly differentiated neuroendocrine carcinoma in two patients and a moderately differentiated neuroendocrine carcinoma in one patient. After surgical treatment and radiochemotherapy, the patients with a poorly differentiated carcinoma survived for seven and 17 months respectively and the patient with a moderately differentiated carcinoma survived for 30 months. The patients investigated showed findings consistent with those of previously published cases with regard to the parameters investigated. CONCLUSIONS: NETL require more extensive staging investigations and a specific treatment adapted to the subtyping. Treatment at specialized centers with publication of individual cases is desirable to extend and deepen knowledge.

Diagnosis, Differential↗
PubMed2006

Eosinophilic nasal polyps are a rich source of eotaxin, eotaxin-2 and eotaxin-3.

INTRODUCTION: The CC-chemokine eotaxin plays a key role in the pathologic mechanism of tissue eosinophilia in nasal polyposis. In this study, we investigated a possible role of eotaxin-2 and eotaxin-3, the recently discovered members of the eotaxin family. METHODS: Nasal polyps from 24 patients (non allergic/allergic/aspirin-intolerant patients) and turbinate tissue from 8 controls were investigated. Chemokine protein content (eotaxin, eotaxin-2, and -3) of tissue homogenates was measured by ELISA. Paraffin sections of samples were stained to determine the extent of eosinophilia. RESULTS: Protein expression of eotaxin, eotaxin-2 and eotaxin-3 was significantly higher in nasal polyps than in controls. There was a direct correlation between the protein concentrations of all three eotaxins. Further, protein levels of all chemokines were significantly correlated to the amount of eosinophilia. In aspirin-sensitive polyps the number of eosinophils was significantly higher than in the other patient groups and they had significantly higher eotaxin, eotaxin-2, and -3 protein levels than non-allergic and significantly higher amounts of eotaxin-3 compared with allergic patients. CONCLUSIONS: Our findings suggest, that all members of the eotaxin family are involved in the pathogenesis of nasal polyposis. The results are more likely indicative of a complex cooperation between all members of the eotaxin family than of a specific role in the development of eosinophilia and nasal polyposis.

Adult↗
PubMed2003

[Langerhans cell histiocytosis: petrosal remodelling after chemotherapy--case report and review of the literature].

We report the case of a child presented by her parents to the ENT outpatient service for swelling of the right temporal bone. The child had a history of recurrent bilateral inflammation of the middle ear. Tympanometry revealed a reduced compliance. Due to conductive hearing loss it was impossible to measure otoacustic emissions. Otherwise a normal ENT status was found. Imaging (MRI/CT) demonstrated bitemporal soft-tissue changes with extensive osseous destruction, but no typical imaging signs of an inflammatory, dysplastic or expansive process. The tentative diagnosis of Langerhans' cell histiocytosis (LCH) made on the basis of the clinical and imaging findings was confirmed by biopsy. After exclusion of disseminated LCH, chemotherapy was initiated, and the child underwent follow-up imaging after 3 months. CT showed clear signs of bitemporal reossification. The case reported here illustrates the problems encountered in diagnosing LCH which may present with unspecific clinical symptoms despite advanced osseous destruction. ENT specialists should be familiar with this very heterogeneous entity and think of LCH especially in children presenting with therapy-refractory otitis media, otitis externa, or mastoiditis in order to ensure a timely diagnosis and to thus improve the chances of successful therapy. Imaging modalities (CT, MRI) have a role in the early diagnosis and follow-up of this disorder.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1988

[Vaginal Streptococcus B colonization in pregnancy].

500 women in late pregnancy (III. trimenon) have been examined for colonization of group B streptococci by means of vaginal swabs. Identification of bacteria was effected with modified Wallerströmtest, CAMP-test and coagglutination. In 19 pregnant women (3.8%) B-streptococci could be found. In most cases type I was predominant, followed by type II and III. One newborn child died with symptoms of early onset disease. In mother and infant the same serotype could be found (III/R). The titre of maternal antibody, performed in B-streptococci ELISA was too low. A carrier with B-streptococci had a stillbirth. There existed a congenital abnormality. Both in mother and infant the serotype Ib/c was present. The titre of maternal antibody in B-streptococci ELISA was lowered.

Female↗
PubMed1987

Relative rates of Aujeszky's disease virus attenuation, as assessed in mice.

Field strains of Aujeszky's disease virus (ADV) were attenuated by heat treatment and serial passage at sub-optimal growth temperatures in chicken embryo fibroblasts (CEF). At chosen passage levels, virus was titrated in cell culture and in mice. For each strain, the pathogenicity was expressed as a mouse lethal index (MLI), defined as the inverse of the log10 (CCID50:LD50). MLIs determined for field strains displayed a wide range of comparatively high values. The attenuation of field strains was accompanied by a rapid fall in MLI values, particularly in the initial stages. Heat-treated ADV attenuated faster than untreated ADV, when passaged at 30 degrees C. Passage at 27 degrees C resulted in considerably accelerated attenuation compared to passage at 30 degrees C, in the case of both untreated and heat-treated ADV. MLIs were determined for attenuated ADV strains that had been tested in 6-day-old piglets. Low MLI values were found to correlate with low virulence in piglets and high MLI values with virulence.

Animals↗