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Biomedical subjects

U Frick

Publications and source records attributed to U Frick.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Relations between parameters of lipid metabolism and hemostasis in vascular diseases].

In 98 patients with arterial insufficiency of arteriosclerotic and diabetic genesis correlation analyses were carried out between total cholesterol, HDL cholesterol, triglycerides, creatinine, blood pressure, platelet counts, platelet function and antithrombin III. Besides the known relations between the parameters of lipid metabolism and blood pressure, correlations were found and analysed between antithrombin III, platelet function, renal function and between platelet counts and HDL cholesterol. The importance of the findings for the diagnosis of vascular insufficiency and the relation to normal values are discussed.

Antithrombin III↗
PubMed1983

[Effect of ultraviolet ray irradiation of blood on thrombocyte function and cholesterol level].

Action of the ultraviolet irradiation of autologous blood on thrombocyte function and serum cholesterol values. By means of a screen pressure measurement in vitro in patients with arterial occlusive disease during the course of treatment with ultraviolet irradiation of autologous blood a normalisation of thrombocyte functions is evident. This effect lasted up to a year after beginning of treatment. In the same time a significant diminuation of serum cholesterol levels appeared. The course of these parameters permits a theoretical confirmation of the observed good clinical long term effects of the ultraviolet irradiation of autologous blood and corroborates the acceptability of this therapy in cardiological and vascular dispensaires.

Arterial Occlusive Diseases↗
PubMed1983

[Modification of uremic thrombocytopathy by hemodialysis].

By means of in vitro screen pressure measurement the functions of thrombocytes were detected in dialysis patients before and immediately after dialysis. Start values are below the normal region as a sign of uraemic thrombocytopathia. The expected improvement after dialysis was not to be seen. As a cause of deterioration an activation of the thrombocytes at the surfaces of the capillary kidney and an incomplete inhibition of this process by heparin is discussed.

Blood Platelet Disorders↗
PubMed1983

[Implant materials].

Explore the source record for details and available documents.

Biocompatible Materials↗
PubMed1983

[New aspects of therapy with blood and blood components].

For diminishing transfusion risks and for ethical and economical reasons a rational hemotherapy is indispensable. The "Berner model" referred to here contains an acceptable explanation. It is evident that the overwhelming part of surgical interventions is accomplished by using erythrocyte concentrates. Therefore, fresh whole blood and fresh frozen plasma are better available. Coagulational active plasma fractions have unchanged indications for a rational substitution of coagulation factors. New indications for some blood components are described.

Blood Coagulation Factors↗
PubMed1982

[Effects of ethinyloestradiol sulphonate in soft-gelatin capsules on coagulation parameters of weaning women (author's transl)].

Two groups of 16 puerperae each with and without low doses of ethinyloestradiol sulphonate in soft-gelatin capsules were involved in studies into coagulation parameters as well as into basophilic leucocytes and antithrombin III.--No statistically significant difference was found to exist between the two groups. Both the basophils and antithrombin III were strongly reduced in the two groups.

Blood Coagulation↗
PubMed1980

[Disorders of haemostasis in postoperative septicaemia (author's transl)].

In 27 patients suffering from postoperative septicaemia blood coagulation was analysed. All these patients had chronic consumption coagulopathy, which could be demonstrated under controlled heparin medication. The high fibrinogen concentrations detected immunologically or by heat coagulation had to be revised compared with a method which only recorded clottable fibrinogen. This difference has to be explained by the existence of fibrinolytic split products, fibrin monomers and its complexes with fibrinogen. In all courses an extreme decrease of antithrombin III could be noticed. The results obtained make the necessity of long time heparin therapy dubious.

Adolescent↗
PubMed1979

Consumptive coagulopathy during the Bromsulphalein test--indocyanine green as an alternative.

Liver function tests involving the use of Bromsulphalein can lead to hemolysis and consequent DIC. Latent forms can be detected by means of fibrinolytic degradation products and reduction in the number of leukocytes containing acid mucopolysaccharides of the heparin type, together with an increase in the total leukocyte count as a sign of stress. In comparisons between the bromsulphalein and indocyanine green tests, these parameters have sho4n that liver function tests using indocyanine green are harmless.

Adult↗
PubMed1978

[A new method for the determination of thrombocyte function in patients and in preserved blood].

In a circulating thrombocytic plasma the pressure in front of a defined mesh filter depends on the combined capacity of adhesion and aggregation of thrombocytes. A new clinical in vitro test is based on this principle which comes nearest to the conditions to be found in hemostasis dependent on thrombocytes. Judging from the preliminary results of investigations performed on stored blood, blood donors, patients with thrombocytopenia, disturbances of blood flow and patients under anticoagulant therapy, the time until the pressure rise after administering ADP and the maximal pressure amplitude proved to be the most significant parameters of the new procedure.

Blood Preservation↗
PubMed1978

[Results of a new platelet function test in various clinical diseases and in preserved blood].

In healthy persons, patients with thrombocytopenia and patients with arterial disturbances of blood flow with and without administration of Falithrom the pressure recording was carried out after the combined aggregation and adhesion of thrombocytes. The reaction time particularly observed after administration of ADP revealed marked differences in the groups examined, likewise the maximal pressure amplitude in front of the pumped through filter. When Falithrom was administered the thrombocyte functions were clearly impaired. The reduction of the capacity of platelets to obstruct filter pores can impressively be proved even in those thrombocytes stored in ACD-AG-plasma.

Adenosine Diphosphate↗
PubMed1978

[State and development of liquid conservation of thrombocytes].

In the present investigation the storage effect of AcD-AG and CPD-AG-stabilizers on thrombocytes was tested. The platelets were stored in platelet-rich plasma (PRP) at 4 degrees C or room temperature for 3 days. The concentrates gained by it were marked with Na251CrO4 and reinjected. The thrombocytokinetic parameters were evaluated. The results show that storage with the help of the mentioned stabilizers can be made to a certain extent only. Platelets stored in AcD-AG stabilizerhad a survival time of 2.7 +/- 1.1 days towards 9.0 +/- 1.0 days of fresh whole blood concentrates. The survival time of CPD-AG thrombocytes stored at 4 degrees C for 3 days amounted to 2.0 +/- 0.5 days. Storage of CPD-AG platelets at room temperature showed favourable results. Their survival time amounted to 6.2 +/- 0.6 days. Measurements of surface activity above the spleen and the liver indicate that degradation of stored platelets is mainly performed in the spleen. Problems of liquids storing in view of the significance of therapeutic thrombocyte substitution for hospitals are referred to.

Blood Cell Count↗
PubMed1978

[Studies of thrombocyte function in CPD blood].

The CPD stabilizer according to Gibson with an addition of 1.25 mMol adeninesulfate and 2.50 mMol guanosine is used in blood storage for better preserving 2.3-bis-phosphoglycerate of erythrocytes. Here platelet-rich CPD plasma was investigated before and during a 3 days storage at 4 degrees C or room temperature with regard to preserving the global thrombocyte function. The latter consists in the ability to seal blood vessels and is tested by means of pressure registration in combined thrombocyte-aggregation-adhesion (DKTA method) as an ability to close the pores of a sieve by adding 10(-5) mM/l of ADP. At room temperature this thrombocyte function is approximately 0 following 3 days of storage in CPD plasma excess without shaking. When stored at 4 degrees C it is preserved to a slight degree. Loss of thrombocyte function will depend on pH, thus being particularly evident at room temperature.

Blood Platelets↗
PubMed1978

[Postoperative changes of the thrombocyte number and function].

In 30 patients the number of thrombocytes was determined 24-48 hours after surgical interventions and compared with the normal range. The function of thrombocytes was determined by the method of pressure registration in combined thrombocyte-aggregation-adhesion (DKTA method). In spite of the occurring thrombocytosis there is a tendency towards a decrease of response in most cases and thus of haemostatic function of blood platelets. The influence of the thrombocyte function caused by fibrinolytic split products or by a change of prostaglandine metabolism is discussed.

Blood Cell Count↗
PubMed1977

[On the causes of intra- and post-operative consumption coagulopathies and postoperative thromboembolism].

The determination of the onset of a disseminated intravascular coagulation (DIC) is examined shortly after its intraoperative andpost-operative dissolution with the help of easily performable haematological and physiological clotting tests in 20 patients. In this connection the operation is appreciated as a model even for other processes defined at the beginning, where DIC can be observed. Whereas the aethanol test, the determination of fibrinogen split products (FSP) and the euglobulin lysis time indicate the beginning of DIC more clearly in the form of average values, the aethanol test, partial thromboplastin time and thrombin time have a prognostic value for each patient. As it is too time consuming to determine FSP, the counting of basophilie granulocytes may be used for the diagnosis. In the initial phase of and post-operative DIC will determine the essential share of predisposition to post-operative thromboembolism.

Basophils↗