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Biomedical subjects

U Fuchs

Publications and source records attributed to U Fuchs.

At least 55 records · Page 3Linked to original sources
PubMed1989

Prognosis of conjunctival melanomas in relation to histopathological features.

Twenty-six patients (age 29-85 years) with primary malignant melanoma of the conjunctiva were analysed for usefulness of various histopathological and immunohistochemical features of the primary, recurrent and metastatic tumours in evaluating their prognosis. The mean follow-up time was 5.5 years, ranging from 8 months to 17 years. Eight patients developed metastases and seven have died. The mean time from diagnosis to death due to metastasis was 3.8 years (range 1-6 years). The site of the primary tumour seemed to be most closely correlated to high metastatic risk. Only two of the sixteen limbal melanomas metastasised, whereas two of the four bulbar, all three tarsal and the only diffuse primary tumour caused metastatic disease. Two of the metastasising primary tumours were less than 1.5 mm thick, but all exceeded 0.8 mm in thickness. The mitotic rate, the amount of inflammatory infiltrate, the cell type or the presence of adjacent intraepithelial involvement did not obviously correlate to treatment outcome. Furthermore, the expression of S-100 protein and neuron-specific enolase (NSE), both suggested to be prognostic indicators in cutaneous melanoma, did not correlate to the tendency of the conjunctival melanomas to recur or metastasise.

Adult↗
PubMed1989

[The hormone profile in serum and cervix secretions in the course of a menstrual cycle].

Serum and cervico-vaginal secretion were examined for LH, E2, progesterone and relaxin content throughout a cycle. Estimations were carried out using radioimmunoassays. LH, E2 and progesterone were found in markedly lower concentrations in cervical-vaginal secretion than in serum. Relaxin was detected only in cervical-vaginal secretion with the exception of one serum sample.

Adult↗
PubMed1989

[Hormonal changes in buserelin therapy].

Buserelin has been applied intranasal in 31 women of the reproductive age for endometriosis that had been diagnosed by laparoscopic and bioptic means. The treatment period was 6 month and hormonal changes were evaluated after 2, 4, 8, 12, 17, 20, and 24 weeks. After 2 weeks we observed a decrease of FSH to the lower normogonadotropic range, and of progesteron to less than 0.5 ng/ml. After 4 weeks LH decreased to the lower normogonadotropic range and E2 was below 55 pg/ml. Prolactin concentrations varied between 6 and 8 ng/ml.

Adult↗
PubMed1989

Experimentally induced acute changes in veins studied by scanning microscopy.

Endothelial damage caused by hypoxia and the local administration of Varicocid, or by using vascular clamps on the jugular vein of rabbits, was studied under a scanning electron microscope. Adhering platelets and fibrin were found only in the acutely damaged veins with endothelial defects. Swelling and vacuolization of endothelial cells did not induce intravascular coagulation. Adhering thrombocyte aggregates and fibrin strands can be found on the venous wall after acute changes under a scanning microscope only if part or all of the endothelial lining has been lost. Intravascular coagulation is not induced by swelling or vacuolization. The jugular vein of rabbits was studied after hypoxia, the administration of Varicocid and the use of vascular clamps.

Animals↗
PubMed1989

[The effect of buserelin therapy in endometriosis].

We have treated 31 patients for 6 months at the UFK Tübingen. The AFS-score declined from 7.3 to 3.6, and the--for adhesions corrected--implantation-score from 3.5 to 0.5. Last decline was statistically significant. The endometriosis-specific symptoms disappeared almost completely under Buserelin-therapy. Therapeutic concentrations of E2 (less than 55 pg/ml) were achieved after 4 weeks of therapy. Vaginal bleeding occurred in the first month in 48%, in the second month in 9%, and in the following month in 6% of our patients. With respect to weight, blood pressure, cholesterol, triglycerides, GOT, GPT, and calcium, there were no statistically significant changes before an after buserelin-therapy for 6 months. The pregnancy rate was, so far, 31%, and the reappearance of clinical symptoms occurred in 6.5%.

Administration, Intranasal↗
PubMed1989

The action of oxytocin on sperm motility. In vitro experiments with bull spermatozoa.

The effect of oxytocin on sperm motility of bull spermatozoa was investigated over a period of 2.5 hours. Measurements were carried out with a Lazymot apparatus, depending on the Laser-Doppler principle. In a concentration of 10 IU/ml, oxytocin was found to significantly increase the percentage of motile spermatozoa and sperm velocity compared with saline controls.

Animals↗
PubMed1988

Immunoreactive relaxin in human cervico-vaginal secretion.

Relaxin was measured in cervico-vaginal secretion of non-pregnant women of reproductive age using the heterologous radioimmuno-assay for porcine relaxin. It was detected in about three-quarters of the samples collected. The mean value of the 529 samplers tested was 599 pg/ml. There was a slight trend to higher relaxin values during the second week of the menstrual cycle.

Adult↗
PubMed1988

[Increased capillary vulnerability in diabetic retinopathy].

The retinal capillary network is isolated by Cogan and Kuwabara's method. During prolonged trypsinization the capillaries lose their endothelial cells and pericytes and are transformed into cell-free tubes consisting of basement membranes. This occurs earlier in patients with stage I or II retinopathy than in controls with normal carbohydrate metabolism and patients with stage I hypertension. Therefore, the intercellular junctions and the adhesion between endothelial cells and subendothelial basement lamella are more loosely structured in diabetics than normal subjects, and the cells do not resist the tryptic attack as well. The higher capillary vulnerability demonstrated in these experiments contributes to bleeding and exudation. Whether the local loss of cells in the microcirculation of diabetics occurs primarily in vivo or is only unmasked in vitro manifesting pre-existing cellular damage is discussed.

Aged↗
PubMed1988

Smear and imprint technique in malignant melanoma of the eye.

Cell smears and imprints of malignant uveal melanomas give additional information about cell morphology as compared to routine histology and electron microscopy. They also allow histochemical procedures without the need to cut the specimens. Moreover, they are economical, and rapid to perform. Differentiation between melanoma cells, white blood cells and endothelial cells is made possible by using antibodies to each cell type, and such preparations are especially suitable for immunohistochemical studies, since tissue processing is avoided. In addition to the study of melanoma cells, this method should merit more attention in ophthalmic pathology than it hitherto has received.

Aged↗
PubMed1988

Histopathology of enucleated intraocular melanomas irradiated with cobalt and ruthenium plaques.

Eight malignant uveal melanomas irradiated with Stallard's 60Co applicator or Lommatzsch's 106Ru/106Rh applicator were studied by light microscopy and immunohistochemistry to analyse tumour cell morphology, antigenic expression and inflammatory cell infiltration in relation to radiation dose. The tumours were enucleated 1 to 24 months after irradiation because they did not regress or continued to grow. One patient has later died of metastatic disease. Eight uveal melanomas that were not irradiated were studied for comparative purposes. Radiation necrosis was found only in two cases. In four irradiated and in one control melanoma conspicuous collagen fibres were present in the basal part of the tumour. No difference was noted between the two groups in the number of mitotic figures or in the morphology of tumour cells. In all cases but one, more than half of the tumour cells were variably positive for S-100 protein. Neuron-specific enolase-positive melanoma cells were few in number and occurred in small clusters, and were somewhat more common in irradiated cases. A few lymphocytes and macrophages, which were preferentially found near the choroid, infiltrated every melanoma, but only single cells were associated with radiation necrosis. A mild scleritis near the tumour was present irrespective of irradiation. Although the melanomas were quite large for irradiation, the lack of necrosis in optimally irradiated basal parts of the tumour additionally indicates substantial radioresistance.

Adult↗
PubMed1988

Three theses on thrombosis of the veins.

Thrombosis of veins may be 1. the consequence of damaged endothelial cells, 2. the result of a synergism between local stasis and hypercoagulable blood and 3. the involvement of veins in local intravascular coagulation in microcirculation.

Animals↗
PubMed1986

[Is there a hyporeactivity of the vascular wall to atherogenic risk factors?].

The hypothesis is promoted that the arterial vessel can modulate the response to atherogenic factors. Patients with the same index of atherogenic factor may have different degrees of arteriosclerosis. The verification of this thesis needs a prospective study. The second fact described is the diminished experimental arteriosclerosis after treatment with the calcium antagonist Nifedipine (Corinfar).

Aged↗
PubMed1986

[The vascular wall and fibrinolysis--pathologic aspects].

The plasminogen activating factor of tissue detectable by fibrinolysis autography is diminished in varicosis with and without postthrombotic syndrome, in diabetic nephropathy, in viral pneumonia and after short-term cyclophosphamide therapy. The only condition in which an increase of this factor can be observed is mechanical damage of tissue. The importance of the findings for pathogenesis and therapy is stressed. Whether the results are influenced by inhibitors of extrinsic plasminogen activation is discussed.

Diabetic Nephropathies↗
PubMed1985

Arterial calcification in diabetics.

Calcification of the media of the arteries of the lower limbs, giving a linear type of calcification roentgenologically is typical for diabetic arteriosclerosis. Spotty calcification of the arteries of the lower extremity, which histologically is found in the intima, is also seen a little more often in diabetics with gangrene. There are no major differences between the other histological vascular structures of diabetics and arteriosclerotics. Maximal stenosis of the lumen is found more peripherally in diabetics than in persons with normal carbohydrate metabolism. The results favour the idea of predominant femoropopliteal occlusion in arteriosclerosis and popliteal-tibial occlusion in diabetics.

Arteriosclerosis↗
PubMed1985

Morphometric analysis of retinal blood vessels in retinopathia diabetica.

A quantitative investigation of the retinal blood vessels was carried out in 80 diabetics and 20 metabolically healthy controls of the same age and sex distribution. The blood vessels were isolated by trypsinization, stained with PAS, and analyzed by light microscopy. After 1-5 years' duration of diabetes mellitus, capillary lesions in the ocular fundus can be seen microscopically in the slides, but not with a stereomicroscope. In the retinae of persons with normal carbohydrate metabolism, capillary defects were found to a far lesser extent; they were also always localized in the periphery of the retina, whereas the diabetic lesions were localized in the retinal center. In the diabetics, both capillary lesions (e.g., loss of pericytes) and damage of the retinal neurons occurred nearly simultaneously and with the same retinal localization. This suggests that the capillary lesions are not the cause of neuronal degeneration but that both events are caused by the same mechanisms of pathogenesis.

Adult↗