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Biomedical subjects

U Fuchs

Publications and source records attributed to U Fuchs.

At least 91 records · Page 5Linked to original sources
PubMed1980

Phagocytosis of inert particles in the reticuloendothelial system in rats with experimental insulinopenic diabetes.

Phagocytosis of inert, radioactive gold particles in the reticuloendothelial system in rats in the case of experimental insulinopenic diabetes was studied. In the spleen, phagocytosis was seen to have fallen to a relatively low level after four weeks from the induction of diabetes. In the liver, there was noted a reduction of phagocytosis per gram of organ, though it remained the same for the total organ which in the case of diabetes mellitus increases in weight relative to body weight. This difference in reaction of the reticuloendothelial system in the liver and spleen has also been observed in mice with tumors. The importance of the findings of the present study for increased sensitivity to infections of poorly controlled diabetic patients is discussed in greater detail.

Animals↗
PubMed1980

[Frequency of metastases of extracranial tumours in the choroid plexus (author's transl)].

5% of malignant extracranial tumours metastasize into the choroid plexus, especially tumours with a higher grade of malignancy. Metastases in the choroid plexus are more frequent than mestastases in the brain corresponding to the relation of weight of choroid plexus and brain. This fact can be explained with the vascularisation by capillaries containing endothelial pores. It remains obscure whether there are other special biochemical or immunological mechanisms too, causing the frequency of metastases in the choroid plexus.

Adult↗
PubMed1978

[Comparison of the results of computer tomography and isotope diagnostics in pathologic processes of the infratentorial range (author's transl)].

1. Computer tomography is much more clearly superior to cranial scintigraphy with regard to the identification and localization of pathologic infratentorial processes, than in the supratentorial range. 2. Computer tomography alone solves many diagnostic problems relating to the infratentorial range, but it cannot by any means solve all the problems. 3. The diagnosis identifying the kind of infratentorial growing and displacing tumors cannot be safely established either by computer tomography alone or by a combination of computer tomography and cranial scintigraphy. 4. Cranial scintigraphy and CSF scintigraphy can supply additional informations, support the diagnosis, or contribute towards establishing the final diagnosis, in cases where computer tomography alone supplies ambiguous, questionably positive or discrete answers. In such cases, the emphasis is on the etiologic grouping of unclear forms of hydrocephalos.

Astrocytoma↗
PubMed1978

[Cysts in the villous stroma of the placenta in maternal diabetes mellitus (author's transl)].

Edemateous placentae of diabetic mothers have been examined by light as well as electron microscopy. In addition to typical fetal capillaries there were observed thin-walled cysts containing Hofbauer-cells rather than blood cells which, unlike the capillary system, cannot be filled up with intraarterially injected ink. Derivation and significance of these cavities are discussed. They are considered to be a possible expression of frustraneous extracapillary formation of new vessels. The changes, while not specific, are characteristic of the placenta in maternal diabetes mellitus.

Cysts↗
PubMed1977

Renal biopsies performed on diabetics.

Metabolic disorders and immunological factors are discussed in connection with the pathogenesis of diabetic microangiopathy. Renal biopsies were obtained from 22 diabetics (8 women aged 18 to 53, 14 men aged 15 to 52). 7 of the 22 patients had been suffering from diabetes for 2 weeks to 3 years, 10 for 7 to 25 years, 2 showed a pathological glucose-tolerance test, i.e., they had been "latent" diabetics, and 3 patients, had been so-called "potential" subjects of diabetes due to hereditary traits or delivery of big babies. They were examined by light miroscopy as well as by immunofluorescence microscopy. A number of cases were chosen for the differentiation and counting of glomerular cells (n=8) as well as for electron microscopic (n=7) and polarizing-microscopic (n=6) examinations. Histologically, focal proliferations of mesangial cells as well as an increase in mesangial substance in the glomeruli was found in all cases, although in a varying degree of intensity. These results were confirmed by both the glomuerular cell count and electron-microscopic examination. Immunofluorescence microscopy made it possible to detect frequently both IgA (9/17) and IgG (9/17), usually in either linear or mesangial arrangements whereas it was less frequently possible to detect IgM (1/17) and albumin (1/8) and impossible to detect beta1C in the glomerulus. Labeled insulin was detected five times in the glomerulus. Polarizing-microscopic measurements made in order to discover possible submicroscopic variations in the structure of GBM showed deviations in the average values of anisotropic indices from the controls in the group of long-term diabetics only. The pathogenesis of diabetic microangiopathy may be described as an inflow of immunoglobulins and serum proteins into the mesangium because of an alteration of the capillary endothelium, the mesangial cell being thus caused to overfunction, proliferate and produce an excess of mesangial matrix. In prolonged diabetes the mesangial cell, so far as its own metabolism is concerned, will finally be affected to the point where its power of synthesis is modified in the sense of an excess and/or faulty composition of GBM (glomerular basement membrane).

Adolescent↗
PubMed1977

Scanning electron microscopy of the aorta.

The folds of the intimal surface do not represent the endothelia. Rather, they are produced by tissue shrinkage occurring during preparation, with the shrinking process proceeding in the arteriosclerotic bed differing from that in the normal vessel wall. Consequently, the surface appearance, or texture, of arteriosclerotic beds is different from that of the normal vessel wall. Administration of angiotensin results in the deposition of parietal microthrombi and fibrin filaments as well as in the adhesion of mononuclear leukocytes to the inner coat of the vessel.

Animals↗
PubMed1977

The problem of diabetic angiolopathy in sand rats (Psammomys obesus).

No diabetic angiolopathy was found in the retinas, kidneys and skeletal muscles of protodiabetic and overtly diabetic sand rats. The terminal blood vessels were investigated using histological, enzyme histochemical, immunofluorescence microscopic, autoradiographic and electron microscopic methods. There seems to be little or no connection in sand rats between the diabetic metabolism syndrome and the metabolic process leading to angiolopathy.

Animals↗
PubMed1977

Arterial permeability to labeled protein.

Labeled albumin, which was administered intravenously, was detected, with the use of a scintillation counter, in the aortic wall of rabbits. Relative to weight, the permeability index was highest in the aortic arch and abdominal aorta and lowest in the medial thoracic aorta. Angiotensin II and various mediators were found to increase the permeability of the aortic wall.

Animals↗
PubMed1976

The epithelial and capillary basal laminae of the placenta in maternal diabetes mellitus.

The thickness of the epithelial and endothelial basal laminae was determined in placentas from mothers without known metabolic disease (control) and mothers with diabetes mellitus. The measurements were carried out on electron micrographs. Frequency distributions and statistical parameters were calculated; in 20 cases, 16,331 values were measured. In all cases, the epithelial and endothelial basal laminae were thickest in edematous and fibrotic villi. They were thinner in placentas from diabetic mothers than in controls. Particularly thin basal laminae were found in regions with syncytiovascular membrances. The thinner basal laminae found in the placentas of diabetic mothers are considered to be the result of compensatory growth processes with formation of ontogenetically younger villous parts. The thicker basal laminae in fibrotic and edematous villi may result from a swelling of the basal laminae or possibly from an increased synthesis or a decreased decomposition of the basal laminae. The finding of very thin basal laminae in the region of the so-called syncytiovascular membranes may be of importance for the placental exchange function.

Capillaries↗