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Biomedical subjects

U G Sauer

Publications and source records attributed to U G Sauer.

6 recordsLinked to original sources
PubMed2001

White paper on the future chemical policy in the European Union - implications for animal welfare.

In February 2001, the European Commission adopted a White Paper on a Future Chemicals Policy. Its main goals are better to protect humans and the environment from unknown risks through chemicals. The "promotion of non-animal testing" is one of the key elements of the proposed strategy. For low production volume chemicals, only data from in vitro-tests are to be requested. The data requirements for higher production volume chemicals shall be designed flexibly so that only data relevant for the respective chemical are collected. From the point of view of animal welfare concrete risk management strategies should be defined before test batteries are put together. The test catalogues currently listed in the Classification Directive 67/548/EEC are to be replaced by tiered testing strategies, and concrete waiving strategies are to be designed so that the requested tailor-made testing can actually be realized. Another essential prerequisite for the promotion of non-animal testing is that the funding of alternative method research is formulated as a key action with a concrete budget in the Sixth Research Framework Program of the European Union.

Animal Testing Alternatives↗
PubMed2000

[Reasons for not using primates in research].

In terms of physiological development, non-human primates are our next of kin in the animal kingdom. Scientists who oppose the use of primates for experimental purposes argue that due to the high degree of similarity between primates and humans, experiments that may not be performed on humans due to ethical reasons also should not be performed on primates. Taking neurophysiological experiments with primates as an example, it is discussed which consequences it would have for medical progress if the use of primates in research were abandoned altogether. Taking into account the alternatives available and the results gained with the animal tests, it is concluded that medical progress would be unimpeded, even though in some instances the exact same questions that currently are evaluated with the animal tests might no longer be pursued with the alternatives.

Animal Rights↗
PubMed1993

Glutamine and glutamate in ascitic fluid of dogs.

The amino acid pattern in the ascites of 79 dogs was examined. The concentration of glutamine in neoplastic ascites is significantly lower than in cardial effusions. In contrast, glutamate is significantly higher in neoplastic ascites than in cardial ascites. Using an arbitrary discrimination value of 0.28 for the glutamate/glutamine ratio, purulent or cardial ascites are easily differentiated, with a sensitivity of 100% and a specificity of 94%. The differentiation is very distinct, with no overlap between the group of patients with liver cirrhosis on the one hand and the groups of patients with purulent peritonitis, heart failure, or malignant ascites on the other hand. There was no diagnostically unsable correlation between the concentrations of the other 20 amino acids and the underlying causes of ascites formation.

Amino Acids↗
PubMed1992

[Cellulose acetate electrophoresis, radial immunodiffusion and nephelometry--comparative methods for the determination of albumin].

Different methods for the determination of albumin in dogs and cats are compared. Nephelometry was found to be the method of choice, due to its excellent precision, the immediate test results and the wide measuring range. The advantage of the radial immunodiffusion method is that expensive equipment need not be acquired, which makes the test profitable for small amounts of samples. At the expense of accuracy, electrophoresis enables the simultaneous evaluation of all protein fractions.

Albumins↗
PubMed1991

[Clinico-chemical study of body cavity effusions].

The differential diagnosis of ascites is discussed. 107 dogs with ascites were examined. The mean age of the dogs was relatively high. Therefore many dogs were multimorbid. The classification of ascites into transudate and exudate was of limited value. The activity of the lactate dehydrogenase (LDH) in the ascitic fluid was a potent parameter in differentiating cardiac, neoplastic and infectious ascites. For the diagnosis of a neoplastic cause of the ascites, a LDH activity range from 200-1600 U/l was useful. The predictive value of the positive result was 87%, and the predictive value of the negative result was 88%.

Animals↗