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Biomedical subjects

U Goebel

Publications and source records attributed to U Goebel.

24 records · Page 2Linked to original sources
PubMed1986

Intermediate-dose methotrexate in the treatment of childhood acute lymphocytic leukaemia: lack of benefit during maintenance therapy following intensive induction therapy.

One hundred and fifty-one children with acute lymphocytic leukaemia (ALL) received multiple agent induction chemotherapy followed by intensive phase treatment. One hundred and thirty-seven patients were randomised for the first year of maintenance treatment to receive reinforcement therapy (pulses) with either intermediate-dose methotrexate (ID-MTX) and prednisone (PRED) or vincristine (VCR) and PRED. The probability of continuous complete remission (CCR) at 5.5 years is 0.80 for the ID-MTX group and 0.84 for the VCR group. Extramedullary relapses were not prevented either in the ID-MTX group nor in the VCR group. Since in previous studies VCR/PRED pulses did not increase CCR rates when given after intensive combination chemotherapy, it can be concluded from this study that neither did ID-MTX reinforcement therapy further improve treatment results in our patients with ALL when given after aggressive chemotherapy.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

[Therapy of acute lymphoblastic leukemia in childhood. Multicenter prospective therapy study COALL-80].

Since 1979 in a cooperative study (COALL-80) 110 children with acute lymphoblastic leukemia (ALL) and 13 children with high grade malignant non Hodgkin's lymphoma (NHL) have been treated with a less aggressive modification of the Westberlin Study Program BFM 76/79. Asparaginase has been delayed from the initial 4 drugs regimen and interposed in between induction therapy and treatment of central nervous system (CNS). Induction therapy that way was well tolerated and realized mostly on an outpatient basis. The expected 2 1/2 years disease free survival rate for ALL is 86% and no worse than the results of the original BFM study. We were able to define by age (greater than 2, less than 7 years), initial blast count (less than 25000/mm3) and immunological typing (cALL Ag+) a great group of patients (52%) which has remained in continuous remission as a whole. For this group further reduction of therapy intensity is planned (omission of cyclophosphamide during CNS-phase and use of intermediate dose methotrexate (MTX-mHD) instead of CNS-irradiation).

Age Factors↗
PubMed1983

[The pathogenesis of otitis externa].

In otitis externa the formerly grampositive colonization of the auditory canal changes towards a gramnegative microbial flora. Pseudomonas aeruginosa plays a major role in recurrent infections and in swimmer's ears. Various serotypes of ps. aeruginosa i.e. type 1;6 and 5 could be isolated. In swimmer's ears ps. maltophilia was identified twice. There was no correlation between the severity of the disease and the protease and lipase activity of pseudomonas isolates. Exoenzyme activity seemed to bear influence on the chronicity of the disease. Therapeutic success led to a decline of enzymatic activity.

Adult↗