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Biomedical subjects

U Greinert

Publications and source records attributed to U Greinert.

4 recordsLinked to original sources

[Clinical atypical mycobacterial infections].

In adults atypical mycobacteria usually cause pulmonary disease, lymphadenitis in children and disseminated disease in the course of the acquired immunodeficiency syndrome. Apart from that atypical mycobacteria lead to cutaneous lesions as well as to local abscess formation and necrotic tissue lesions following accidental or iatrogenic trauma of the skin or the soft tissues. Whereas well-established and upcoming microbiologic procedures easily allow an exact classification of the organism, clinical diagnosis is sometimes problematic.

Humans

[Immunologic parameters in lung tuberculosis].

In patients with pulmonary tuberculosis serum immunoglobulin levels are found to be increased, quantitative deviations from the norm are observed on analysis of the mononuclear cells, there is an increase in the number of circulating immune complexes, and, in the event of extensive pulmonary involvement, an attenuation of cell-mediated cutaneous reactions is seen. In accordance with the chronic course of the disease, a return to normalcy of these parameters in the healing phase occurs only gradually.

Antigen-Antibody Complex

[Increased serum IgE concentration in lung tuberculosis].

In about one-half of patients with pulmonary tuberculosis, elevations of the IgE serum concentrations are found which, under anti-tuberculous therapy, reveal a tendency to regress. Aetiologically, in addition to an unspecific B-cell activation, a specific reaction of the immune system may be considered.

Adolescent

[Determination of immunologic parameters in patients with lung tuberculoses of various stages with special reference to serum IgE concentration].

In patients with lung tuberculosis--depending on the severity of the disease--delayed-type hypersensitivity reaction is weakened, also in cases of non-miliary tuberculosis. On analysing the mononuclear cells of peripheral blood, abnormalities are found, in particular an increase in the monocyte count. In addition to increasing levels of serum immunoglobulin A and G, circulating immune complexes were detected in 50% of the patients. In 50% of the patients we found elevated IgE-serum levels, which decreased in response to treatment but did not return to normal.

Adolescent