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Biomedical subjects

U Hørding

Publications and source records attributed to U Hørding.

50 records · Page 3Linked to original sources
PubMed1988

Mid-trimester therapeutic abortion by intra-amniotic prostaglandin F2 alpha and concomitant oxytocin.

The routine use of intra-amniotic PGF2 alpha and concomitant intravenous oxytocin for second trimester induced abortion is evaluated in 274 consecutive cases. Eighty-five per cent of the nullipara and 90 per cent of the parous women aborted within 24 hours and all but one within 48 hours following a single intra-amniotic dose. Doses were 40 or 50 mg PGF2 alpha and the mean induction-abortion interval was not shortened by the higher dose. Neither did gestational age have any effect on abortion time. Postabortum haemorrhage occurred in 22 cases in spite of routine curettage. Parametritis was reported in eight cases. In two nullipara, cervical tears were observed, in one case forming a persisting fistula to the uterine cavity. There were no significant toxic side effects to the administration of PGF2 alpha or oxytocin. It is concluded that the method has not been superseded with regard to efficacy of abortion induction and that the rate of more serious complications is not above what can be expected from any other available method of second trimester pregnancy termination.

Abortion, Therapeutic↗
PubMed1986

Urinary incontinence in 45-year-old women. An epidemiological survey.

In an epidemiological health survey, 515 45-year-old women were interviewed about urological problems, particularly incontinence. A pelvic examination was also conducted on 509 of the women. Twenty-two per cent or 114 women stated that they experienced incontinence, which took the form of stress incontinence in 75%, urge incontinence in 11% and a mixture of the two in 14%. Only 14 women, 3% of all the women interviewed, desired medical treatment for incontinence. In the incontinent women, the pelvic examination significantly more often revealed a cystocele, uterine prolapse or impaired function of the levator muscles. No correlation was found between an enlarged uterus and incontinence. In 211 women with one or more of these findings at the gynaecological examination, the frequency of incontinence was 35%; in 298 women with no pathological findings, the frequency was 15%. The frequency of urinary incontinence was not increased in women with higher parity or in postmenopausal women.

Denmark↗
PubMed1985

Stage I endometrial carcinoma: a review of 140 patients primarily treated by surgery only.

One hundred patients with stage Ia and 40 patients with stage Ib endometrial carcinoma had hysterectomy and bilateral salpingo-oophorectomy performed as the only primary treatment. Sixty-two percent of the patients had well-differentiated tumors, 31% moderately differentiated, and 7% undifferentiated tumors. Information on myometrial invasion was not available. The overall 5-year survival was 0.92 and the 5-year survival by tumor grade 0.96, 0.90, and 0.80 for patients with grade 1, 2, and 3 tumors, respectively. Survival rates decreased significantly with increased tumor dedifferentiation. Prognosis was not affected by enlargement of the uterine cavity or by higher patient age. Of 7 cases of isolated vaginal or pelvic recurrence, 4 could by controlled by irradiation therapy. These results compared to reported results of combined therapy suggest, that in well-differentiated cases-the majority of stage I endometrial cancers-combined therapy of surgery and irradiation presents no advantage over simple hysterectomy.

Adult↗
PubMed1985

Bromocriptine in the treatment of carcinoma of the cervix: a phase II trial.

Twenty patients with advanced carcinoma of the uterine cervix were treated for at least 3 months with 5 mg bromocriptine daily. No remissions were found (95% confidence limits, 0-17%), neither among normo- nor among hyperprolactinemic patients. Twelve had stable disease for 2-9 months with a median of 3 months. The results of this study does not support the hypothesis that bromocriptine possesses any antitumor effect in cancer of the uterine cervix.

Adult↗
PubMedDate not supplied

Prevalence of human papillomavirus types 11, 16 and 18 in cervical swabs. A study of 1362 pregnant women.

Cervical smears from 1362 pregnant women were examined by filter in situ hybridisation for human papillomavirus (HPV) types 11, 16 and 18. 119 women (8.7%) had HPV-positive smears, HPV 16 being the most common type (61% of all infections). There was a correlation with age (r = 0.63, p = 0.004), the highest incidence found in women less than 22 years old with a decline after the age of 30. The incidence of cervical HPV infection was significantly higher (20.3%, p less than 0.01) in the subgroup of women with past or present vulvar condyloma, but not in women with previous pelvic inflammatory disease or genital herpes. In 18 women with current dysplasia the smears harboured HPV 16, 18, or both in eight cases (40%). The incidence of HPV infection in 71 women with earlier dysplasia did not differ from that of the women who never had dysplasia.

Adolescent↗
PubMedDate not supplied

Filter in situ hybridisation: an evaluation of the FISH technique for HPV detection in cervical swabs.

The filter in situ hybridisation (FISH) method for detection of HPV in cervical swabs was evaluated against the Southern blot technique on concomitant cervical biopsies. Of 73 biopsies, HPV 16 DNA sequences were found in 26 biopsies and HPV 18 sequences in 2 biopsies. Analysis by FISH of the corresponding smears detected 58 and 100% of these, respectively. Of the smears corresponding to the HPV-negative biopsies, 17% were HPV 16-positive and 3% were HPV-18 positive by FISH. Re-hybridisation with cold plasmid added for competition did not change these results. To estimate the risk of spurious hybridisation between vector remnants in the probe and bacterial DNA sequences present in smears, we have hybridised by FISH to preparations of the 19 most common vaginal microorganisms. Of these, E. coli, which is present in about 10% of cervical smears, hybridised strongly with a probe of the plasmid vector pBR322 and may be a significant cause of false positive FISH results. None of the bacteria hybridised with probes of purified HPV when cold, denatured plasmid was added for competition. Analysis by FISH with probes of purified pBR322 to 167 smears of a patient control group resulted in 6% positive reactions. In hybridisations with probes of HPV 16 and 18 to 2 or 3 different filter preparations of the same smear, identical results were obtained in 18 of 19 smears, indicating a good reproducibility by the FISH method. The high percentage of HPV negative smears is equivalent to the rates known from cytology and may reflect sampling errors.

Biopsy↗
PubMedDate not supplied

Human papillomavirus (HPV) in vulvar dysplasia and carcinoma in situ.

Surgical specimens from 62 patients with vulvar dysplasia and carcinoma in situ were morphologically investigated. Lesions were classified according to WHO (mild, moderate, severe dysplasia and carcinoma in situ) and according to Toki et al. (1991) (warty, basaloid, combined warty/basaloid or basaloid/warty types or mixed (warty, basaloid and simple) forms). Following the WHO classification, moderate dysplasia was shown in 4 cases, severe dysplasia in 47 and carcinoma in situ in 11 cases. Pure warty type was shown in 2 cases (both biopsy specimens). One case revealed pure simple dysplasia whereas no case of pure basaloid type was found. Various combinations of warty and basaloid types were shown in 52 cases and mixed forms in 7 cases. The results indicate that pure forms of warty and basaloid types probably do not exist. HPV DNA was detected by PCR in 51/58 cases (88%) (45 with HPV type 16 and 6 with HPV type 33) evenly distributed in all age groups and in all types of lesions (WHO and Toki et al. 1991). By ISH HPV was detected in 24/62 cases (39%) (21 with HPV type 16/18 and 3 with HPV type 31/33), nearly always in warty areas. All these cases were positive for the same virus type by PCR. No case revealed more than one type of HPV. HPV type 6, 11, 18, and 31 were not detected by PCR. The results indicate a correlation between HPV type 16 and 33 and dysplasia/carcinoma in situ in the vulva.

Adult↗