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Biomedical subjects

U Hase

Publications and source records attributed to U Hase.

11 recordsLinked to original sources
PubMed1990

Epidural spinal abscesses.

Fifteen cases of peridural empyemas are reported. 12 patients reported with motor dysfunction of the lower extremities and pain radiating from the spine. In one case, localized pain of the spine was discovered and in two cases there were no signs of spinal or radiating pain. Treatment in all cases was laminectomy and systemic antibiotic administration. Microbiological analysis showed staphylococcus aureus in 11 cases. 9 patients recovered with no neurological defects, two had major improvement of the paresis, and one died. Three patients with paraplegia recovered from the primary infection.

Back Pain↗
PubMed1979

The response of focal ischemic cerebral edema to dexamethasone.

Twenty-four h after permanent occlusion of the middle cerebral artery (MCA) in the cat, the hemispheric swelling due to edema is markedly reduced under treatment with large doses of dexamethasone than is the case with the untreated group. The increase of regional water and sodium content in the MCA territory is less in the dexamethasone treated group, whereas the potassium changes in the ischemic tissue showed only small differences between the two groups. The potassium content of the non-ischemic tissue is slightly increased in the dexamethasone treated animals when comparing with the untreated group. RISA activity in the tissue is increased in the grey and the white matter of both groups. The less marked RISA-131 activity in the cortical grey matter of the treated animals indicates blood-brain barrier damage of a smaller degree due to dexamethasone. These findings indicate a beneficial effect of dexamethasone on local ischemic edema. Regarding our results and the pharmacokinetics of this steroid the dexamethasone loading of a patient has to be in the range of about 100 mg per day for the adult, and has to be started immediately after the onset of a stroke.

Animals↗
PubMed1979

[Tumors of the pineal region. Part I: neurologic and neuroradiologic symptoms in 23 patients].

After a short anatomical review about the neighbourhood of the lamina quadrigemina 23 patients with different processes in the pineal region were investigated with regard to their neurological symptoms and radiological findings. Symptoms of the eyes in conjunction with signs of elevated intracranial pressure in most of the cases show the way to the diagnosis which will be completed by ventriculography, angiography, and recently by computer tomography with regard to the expansion of the process; any prediction about the kind of tumour is possible only in a little percentage.

Adolescent↗
PubMed1979

[Tumours of the pineal region: Part II: results of treatment in 23 patients (author's transl)].

The outcome of 23 patients with tumours in the pineal region was investigated following treatment with shunting, irradiation, extirpation or with a combination of these three procedures. The choice of therapy is difficult because in most cases the kind of tumour is unknown. The irradiation of radioresistant lesions however causes an unnecessary injury of the surrounding tissue whereas the trial of extirpation of a radiosensitive tumour exposes the patient to an unnecessary danger. After the results of therapy a method of treatment is proposed.

Adolescent↗
PubMed1978

Intracranial pressure and pressure volume relation in patients with subarachnoid haemorrhage (SAH).

The development of the intracranial pressure after a subarachnoid haemorrhage was evaluated in 21 patients. A statistically significant relation between the intracranial pressure and the neurological findings was found, whereas vasospasms did not influence the intracranial pressure. In patients in a clinically critical condition, rhythmic pressure waves of a frequency of 1/minute were repeatedly observed.

Adolescent↗
PubMed1978

The course of intracranial pressure and volume-pressure relationships following extirpation of meningiomas and astrocytomas.

Thirty-five patients with meningiomas were compared with 37 patients with astrocytomas with respect to the postoperative course of their ICP and elastance. In the case of the meningioma patients, the ICP increased on average over a longer period and achieved higher values than in the astrocytoma patients. In the first group, the elastance attained values that were three times as high as in the second group. There was no fixed relationship between pressure and elastance in the two groups of patients.

Astrocytoma↗
PubMed1978

The influence of the decompressive operation on the intracranial pressure and the pressure-volume relation in patients with severe head injuries.

Measurements of intracranial pressure by ventricular catheter were performed in 47 patients with severe head injuries. Thirty-three patients with decompressive operations such as osteoclastic craniotomy and dilatation by means of duraplastic have been compared with 14 patients with closed heads with regard to volume pressure response (intracranial elasticity). This was determined either by intraventricular injection of 2ml saline or by drainage of cerebrospinal fluid. The examination clearly shows that patients with closed heads have a much higher intracranial elasticity than patients who have decompressive operations, so that in the first group minor differences of the intracranial volume cause extreme deviations of the intracranial pressure. Therefore, the decompressive operation has been advised in severe head injuries with increased intracranial pressure as a measure additional to high dose dexamethasone therapy and hyperventilation.

Brain Injuries↗
PubMed1978

[The measurement of intracranial pressure (author's transl)].

A new method of measuring pressure extradurally was tested in 19 patients and compared in 14 patients with the intraventricular pressure which was also measured. When functioning satisfactorily the values for the extradural pressure were generally around 3-5 mm Hg lower than those which were recorded within the ventricles. The reason for this appeared to be the inadequate length of the adaptor screw which was used to fix the pressure recorder in the skull, so that a small part of the actual intracranial pressure was absorbed by the dura.

Brain Injuries↗
PubMed1978

[Increased intracranial pressure. Methods of measurement, pathophysiology and treatment (author's transl)].

After describing the various methods for measuring the intracranial pressure, the causes of the rise of pressure within the skull and the possibilities for compensation are discussed. The elasticity of the brain tissue, which can be determined by pressure/volume stress, plays a crucial role in compensating for pressure. A reciprocal influence exists between intracranial pressure, cerebral circulation and brain oedema, as well as between intracerebral pressure and peripheral circulation. The treament of raised intracranial pressure is possibly by CSF drainage, hyperventilation and hypothermia, as well as by drugs such as steroids and diuretics.

Brain Diseases↗
PubMed1978

[The cardiovascular response to gradual increase of intracranial pressure in experiments on animals (author's transl)].

Experiments were performed on dogs to examine the cardiovascular response (Cushing' reflex) to slow increase of intracranial pressure (ICP) by means of an epidural balloon. In contrast to the acute increase in ICP, a slow but constant increase of the cardiac output (CO) was observed, followed later by a short and steep increase of blood pressure, in various experiments with different ICP. In the range of ICP from 30 to 100 mm Hg a linear relation existed between the ICP and CO. The experiments indicate that with the slow ICP increase the so-called cardiovascular response does not occur, or only occurs rudimentarily, in contrast to a swift ICP-increase. It seems therefore obvious that a suppression of the cardiovascular reaction occurs which is dependent on the sympathicoadrenergic system by the parasympathetic fibers. The reflex mechanism is discussed. The release mechanism of the circulation reaction is not specifically dependent on pressure but is the consequence of a nonspecific lesion of the circulation centre in the medulla oblongata.

Animals↗