PubMed Health⌕ Search

Biomedical subjects

U Heim

Publications and source records attributed to U Heim.

At least 37 records · Page 2Linked to original sources
PubMed1989

The legumin gene family: structure and evolutionary implications of Vicia faba B-type genes and pseudogenes.

We have characterized several Vicia faba genes encoding methionine residue-free group B subunits of the 11S or legumin storage proteins. The respective gene subfamily consists of 10 to 15 members, six of them having been studied by DNA sequence analysis. Four functional genes (LeB2, LeB4, LeB6, LeB7) are highly homologous in their coding region and 0.3 kb of their 3' flanking sequences. On the other hand, two pseudogenes (psi LeB1, psi LeB5) have accumulated a large number of mutations including an identical 0.7 kb internal deletion; they are both flanked by a repetitive element. Analysis of sequence changes show that transitions are nearly double as frequent as transversions. CpG is the most infrequent dinucleotide whereas TpA is significantly underrepresented in exon sequences. End points of deletions are correlated with short direct repeats and preferentially found in the two introns. Our studies indicate that the Vicia faba legumin B gene subfamily contains a group of expressed, highly homologous genes as well as more diverged pseudogenes.

Amino Acid Sequence↗
PubMed1986

[Pseudarthrosis of the capitate].

A 54 years old railway engine-driver fell on his extended right hand in November 1978. In the next few hours he developed increasing pain. He reported similar slight trauma some fourteen months before, but without pain. The tomographic X-ray examination proved the presence of an isolated non-union of the capitate with some shortening. Four days after the second accident an autologous graft was performed following the technique of Matti. The non-union healed after three months in a plaster cast, and the patient returned to full work after four months. Examining him four years and nine months later, the patient complained about persisting pain when stressed. The mobility of the wrist was moderately reduced, and the healed capitate showed unchanged shortening. Isolated non-unions of the capitate can, therefore, be painless for a long time--a situation well-known with scaphoid non-unions. Considering the operative technique, a cancellous graft alone is not able to restore the function of the wrist because of associated collapse of the carpus. To obtain a better late result, the length of the capitate ought to be restored and a cortico-spongious graft inserted.

Carpal Bones↗
PubMed1985

Subungual glomus tumors. Value of the direct dorsal approach.

The authors operated upon 4 subungual tumors between november 1975 and july 1976. In three cases, the tumor was located under the center of the nail and a direct dorsal approach--atraumatic detachment of the nail and approach via a longitudinal incision of the nail bed--was employed. Excision was performed using microsurgical technique. After trimming and perforation (classical techniques), the nail was replaced and fixed. This approach clearly identifies the boundaries of the tumor and facilitates radical removal. The cosmetic result is excellent. No recurrences have been seen with a 5 year follow-up.

Fingers↗
PubMed1982

[Early diagnosis of stomach cancer: reality or illusion?].

Cancer of the stomach is, in Switzerland, the fourth most common malignant tumor in both sexes. The five year survival rate is between 10 and 20% in Europe; where the cancer is diagnosed early, however, the patients have a survival rate of 85-95%. Of the 305 cases diagnosed in the last 5 years, 51.5% were operatively curable. In 29.5% of the cases palliative surgery was possible and 19% were inoperable. The rate of early cancer is 12% and thereby constitutes the largest portion of the total five year survival rate. Improvement of prognosis is only realizable through early detection, but even today this prospect is largely illusory. Practicable ways of obtaining optimum results are demonstrated.

Aged↗
PubMed1982

[Simultaneous functional bilateral radiographies of the metacarpophalangeal joint of the thumb in hyper-pronation].

Diagnosis of tears of the ulnar collateral ligament of the metacarpophalangeal joint of the thumb is often made by dynamic radiography. In contrary to the usual technic, the best position is forced pronation of the hand. The metacarpal and the first phalanx are horizontal on the X ray plate. The patient is encouraged to push the tip of his thumb against an object thus obtaining a forced abduction. The two hands can be held in place with a tight bandage. This yields a simultaneous and symmetrical image of the two thumbs on the same film.

Finger Joint↗
PubMed1981

[Simultaneous functional testing of the metacarpophalangeal joints of the thumb in hyperpronation using a simple device].

For the diagnosis of rupture of the ulnar ligaments of MP joint of the thumb functional X-rays are required. The best position for this investigation seems to be - contrary to the routine - overpronation where the metacarpal and the proximal phalanx are both lying nearly straight on the board. If the patient pushes the pulp of his thumb against a barrier he produces stress in abdduction. Both hands can be tightly bandaged together in this uncomfortable position for a certain time. This permits a symmetrical and simultaneous image of both stressed thumbs on only one X-ray film. For this purpose we use a simple wooden board with two small borders which is placed over the film case.

Finger Injuries↗