Biomedical subjects

U Janson

Publications and source records attributed to U Janson.

3 recordsLinked to original sources

PubMed1999

Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.

The endogenous cannabimimetic anandamide is hydrolyzed by a fatty acid amide hydrolase to yield arachidonic acid and ethanolamine. In the present study, the regional distribution of the activity and its sensitivity to inhibition by the enantiomers of ibuprofen, ketorolac, and flurbiprofen has been investigated. The rate of [3H]anandamide hydrolysis was found in both 7-week-old and 90-week-old rats to be in the order hippocampus > cerebral cortex > cerebellum > striatum approximately midbrain, with higher rates of hydrolysis for the 7-week-old rats than for the 90-week-old rats. In whole brain (minus cerebellum), the R(-)-enantiomer of ibuprofen was a mixed-type inhibitor of anandamide hydrolysis and was approximately 2-3 times more potent than the S(+)-enantiomer, IC50 values of 230 and 750 microM, respectively, being found. A similar pattern of inhibition of anandamide hydrolysis was seen when intact C6 rat glioma cells were used. Ketorolac inhibited rat brain anandamide hydrolysis, with IC50 values of 50, 440, and 80 microM being found for the R-, S-, and R,S-forms, respectively. The IC50 value for R-flurbiprofen (60 microM) was similar to the IC50 value for the S-enantiomer (50 microM). These data demonstrate that there is no dramatic enantiomeric selectivity of NSAID compounds as inhibitors of fatty acid amide hydrolase enzyme(s) responsible for the hydrolysis of anandamide. The enantiomers of flurbiprofen and R-ketorolac are the most potent NSAID inhibitors of fatty acid amide hydrolase yet reported.

Aging↗

PubMed1993

Normal and deviant behavior in blind children with ROP.

Congenitally blind children, especially with ROP, are at risk for developing autistic traits. Early behavior risk screening would be of value, but no instruments with acceptable specificity are available. Traditional behavioral symptoms of infantile autism also characterize blind children without autistic disturbance. This report attempts at identifying early behavior patterns that distinguish autistic from non-autistic blind children with ROP. Developmental data, parents' reports, and video-recordings are analyzed. It is concluded that observations of developmental delays are not specific enough in screening out the risk group. However, it is possible to describe a behavior pattern, emerging between 12 and 30 months, of unresponsitivity and stereotypic object manipulation, which distinguishes autistic and non-autistic subjects. This might be a pattern of specific risk behavior in blind children. However, further prospective studies must be performed to test these proportions.

Autistic Disorder↗

PubMed1990

Services to families with children. A study of community work in Uppsala.

This article describes some of the results of a study of services to families and children in a suburban district, Sweden. Services included in the study were: maternal and child health care, child psychiatry, services for handicapped children, school health care, day care services, community social services and family counselling services. The baseline studies comprised analyses of official goals expressed in legislation and recommendations, interviews with local politicians and administrators, record studies, studies of working time distribution and questionnaires to field professionals and families. The results indicate that services with traditional goals and well-defined tasks (e.g. health supervision) were more satisfied with their goal attainment, less inclined to collaborate with other services, and more occupied with direct client work than services with non-traditional goals and vaguely defined tasks (e.g. strengthening democracy).

Adolescent↗