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U K Dzhalmukashev

Publications and source records attributed to U K Dzhalmukashev.

6 recordsLinked to original sources
PubMed1989

[Comparative evaluation of the transport of transit hepatotropic compounds based on mathematical modelling].

Specific features of kinetics by the hepatobiliary system 131I-BR, 131I-BS, 99mTc-pVIDA and 99mTc-NIDA have been shown. There is a definite pattern for all coefficients: a1,2 greater than a2,1; a2,1 greater than a2,3 less than a3,4. In this case the phase of absorption (a1,2) six times exceeded that of isolation of an indicator from hepatocytes (a2,3). The main feature consists in the augmented speed of the passage of indicators through hepatocytes in the following sequence: 131I-BR----131I-BS----99mTc-pVIDA----99mTc-NIDA. A three-chamber reversible model is suitable for various hepatotropic compounds.

Adult↗
PubMed1987

[Radionuclide evaluation of liver function in breast cancer based on mathematical modelling].

The paper is concerned with a clinico-diagnostic follow-up of 78 breast cancer patients: stages IIA (8), IIB (12), IIIA (39), IIIB (39), IIIC (10) and IV (9). The results of radionuclide investigations were interpreted using mathematical simulation of 131-I-rose bengal permitting separate assessment of the phases of absorption, excretion and passage via the biliary tracts. Indices of hepatocytic absorptive capacity were as follows: normal function in 41%, accelerated one in 48% and retarded in 11% of the patients. Excretory function was normal in 64%, accelerated in 26% and retarded in 10% of the patients. The indicator return from hepatocytes into the blood was normal in 47%, accelerated in 35% and retarded in 18% of the patients. Kinetics of the agent via the biliary tracts was normal in 80%, accelerated in 35% and retarded in 5% of the patients. Generalized assessment of the liver status has shown that in breast cancer patients normal function is noted in 12%, intensive function in 63% and suppressed function in 25%. A stage of disease has been also shown to influence the liver status; liver function deteriorates with disease spreading.

Breast Neoplasms↗