Biomedical subjects
Publications and source records attributed to U K Ghosh.
The concept that care of elderly people required special facilities and training started early this century but was only implemented with the advent of the NHS in 1948. In Scotland the speciality gradually evolved and grew in stature and prominence. The early pioneers in Scotland are described.
A reliable drug history is not always available, and the constant accurate updating of patients' current medication at a Day Hospital may be difficult. This pilot study examined the use of a qualitative thin-layer chromatographic technique (Toxi-Lab system) applied to urine specimens in assessing drug compliance in the elderly. The system proved capable of detecting 36% of prescribed drugs in a group of elderly patients, and offers a novel and inexpensive approach to monitoring compliance with certain medications.
Three hundred and six antenatal women with confirmed LMP underwent a single real time ultrasonographic examination between 32-40 weeks of gestation. Four parameters viz. BPD, HL, FL and AP having a positive correlation with gestational age were studied. A multiple regression model for predicting gestational age by a single ultrasonographic examination was developed by forward selection method after eliminating multicollinearity; as a high degree of intercorrelation was found between FL and HL, HL was eliminated from the data. The BPD does not have a significant role in predicting gestational age in later pregnancy. The proposed regression equation with FL and AP predicts gestational age 75% of time within +/- 10 days of 95% confidence limit.
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BACKGROUND: Adenomatous hyperplasia (AH) or dysplastic nodule in the liver is considered a preneoplastic lesion. A wide range in its incidence has been reported. AIMS: To study the incidence of AH nodules in autopsy cirrhotic livers and to carry out a comparative study of the cellular proliferative indices. MATERIALS: Retrospective study of 150 cases with cirrhosis of variable etiology at autopsy, over a 15-year period. METHODS: We identified AH on gross examination and studied the morphology. We compared cellular proliferative indices in AH nodules with other liver nodules by using PCNA monoclonal antibody and AgNOR. RESULTS: Alcohol was the commonest etiology (30%), followed by HBsAg positivity (38%). Most patients belonged to the 30-60 years age group, with male predominance. Sixty of the 150 livers showed AH nodules; there were one to four nodules, measuring 6 mm to 50 mm, per liver. 115/122 AH nodules were studied. Ordinary AH (OAH) was seen in 104 and atypical AH (AAH) in 11, with malignant focus (MF) in four. Associated hepatocellular carcinoma (HCC) was seen in 7 cases. A gradual increase in the proliferative indices from surrounding regenerating nodules (SRN) and OAH to AAH to AAH with MF to HCC was observed. In addition, AAH also showed relatively less reticulin fibers. CONCLUSION: The incidence of AH was 40%. In addition to the cellular proliferative indices, relatively less reticulin fibers could be a distinguishing feature for AAH from SRN, OAH and HCC.