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Biomedical subjects

U Kaboth

Publications and source records attributed to U Kaboth.

At least 37 records · Page 2Linked to original sources
PubMed1981

Serum complement factors in human acute pancreatitis.

C3, C4 and total haemolytic activity of serum complement were measured in 35 patients with acute pancreatitis, and were found to be normal or raised in 24 patients (23 survivors). In 3 further patients complement values were low initially, but returned to normal with clinical recovery. In the remaining 8 patients serum complement factors were generally lowered or declined during the course of the disease; all of them died from haemorrhagic pancreatitis. Thus lowered complement factors may be an unfavourable prognostic sign for the course of the disease. Reasons for the decline may be protein loss, blood coagulation disturbances or intrapancreatic activation of complement. The latter possibility is supported by the immunohistological detection of C3 deposits surrounding parenchymal necroses in two patients.

Acute Disease↗
PubMed1980

HLA-antigens in acute and chronic pancreatitis.

HLA-A and B-antigens were determined in 22 patients with acute and in 65 patients with chronic pancreatitis as well as in 165 healthy controls. There was a tendency of over- and underrepresentation of certain antigens indicating that there may be a genetically linked susceptibility of some patients to acute and chronic pancreatitis respectively. For further evaluation of these tendencies on a larger scale a multi-centre study is required.

Acute Disease↗
PubMed1978

Complement system in sodium taurocholate pancreatitis in the rat.

The role of the complement system was studied in Na-taurocholate pancreatitis in rats. Complement activity (CH 50) was determined at various times in the course of pancreatitis. Immediately after induction of acute pancreatitis, serum complement activity declined and massive C 3 deposits could be detected in the vicinity of acinar necroses and necrobioses. After a phase of recovery three to six hours postoperatively a second complement consumption occurred. Lethality rate increased as serum complement activity fell below 50% of preoperative values. The degree of C 3 deposition increased up to six hours. Decline of serum complement activity and deposition within the pancreas seemed to be correlated with histologically demonstrable tissue lesion. The first decline of complement activity in serum is thought to be caused by liberation of complement activating substances within the pancreas due to the detergent action of Na-taurocholate itself. The second decline, however, may be due to the liberation of complement activating and/or destroying enzymes into the blood stream.

Animals↗
PubMed1978

[Involvement of the exocrine pancreas in Wilson's disease? (author's transl)].

A normal exocrine pancreatic function was demonstrated by the secretin-pancreozymin-test in five patients with Wilson's disease either without (n = 2) or with cirrhosis of the liver but without portal hypertension (n = 3). In another patient with cirrhosis of the liver without portal hypertension the pancreas was normal at post mortem examination. In two patients with cirrhosis of the liver and portal hypertension bicarbonate (n = 1) and amylase secretion (n = 2) were diminished. The regression of portal hypertension under therapy with penicillamine in one of the latter cases was paralleled by the return to normal of exocrine pancreatic function. It is concluded that exocrine pancreatic insufficiency in Wilson's disease is dependent on the development and the progression of chirrhosis of the liver and not due to a primary manifestation of the disease itself.

Adolescent↗
PubMed1978

[Asymptomatic chronic-persisting hepatitis B in a young child as source of infection of hepatitis B within a family (author's transl)].

Five members of an eight-member family fell ill with an acute icteric hepatitis B of the same subtype within eleven months. In all probability the source of the infection was a just over one-year-old fostered child with asymptomatic chronic persisting hepatitis B and signs of massive viraemia (usually high HBs antigen concentration, high virus-specific DNA-polymerase activity and positive HBe antigen test). No relation could be demonstrated between HLA constellation and illness in the family members. Since no specific treatment is available, the only possible prophylactic measure is to isolate the child in the present environment, to avoid further cases of the disease.

Acute Disease↗
PubMed1978

alpha1-Antitrypsin in pancreatic diseases.

Lowered, normal or raised alpha1-antitrypsin levels were found in 81 patients with acute or chronic relapsing pancreatitis and pancreatic carcinoma. 51 patients with chronic pancreatitis did not have alpha1-antitrypsin deficiency. Thus, in contrast to other reports, alpha1-antitrypsin deficiency and chronic pancreatitis do not seem to be in common association.

Chronic Disease↗
PubMed1977

[Serum-complement factors in the pseudo-LE syndrome (author's transl)].

In contrast to the situation in disseminated lupus erythematodes, in pseudo-LE syndrome the serum-complement factors C'3 and C'4 are elevated and not decreased in the active stage of the disease. Although both diseases are defined and easily distinguished by the demonstration of the specific pathognomonic autoantibodies, at least in the active stage, they can also be distinguished by determining these two complement factors. The finding also demonstrates a different pathogenesis of the two diseases. The serum concentration of C'3 activator is elevated both in LE and pseudo-LE. In the former, determining C'4 is a more sensitive test than that of C'3.

Autoantibodies↗
PubMed1975

[Monomeric igM in acute and chronic liver diseases (author's transl)].

Monomeric IgM could be found rather frequently in acute hepatitis and chronic aggressive hepatitis and occasionally also in chronic persistent hepatitis. Earlier it was reported in lympho-proliferative-, autoimmune diseases, some infectious diseases and in cirrhosis of the liver. The occurence of monomeric IgM in chronic aggressive hepatitis correlates with the detection of several autoantibodies (ANA, SMA, RF). The 7S-IgM-test may be used as an easily measurable additional criterium for diagnosis and course of chronic liver diseases.

Acute Disease↗