Excretion and metabolism of injected ecdysone in the white mouse.
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Animals↗
Biomedical subjects
U Kerb
Publications and source records attributed to U Kerb.
1-Methyl-1,4-androstadiene-3,17-dione (SH 489): characterization of an irreversible inhibitor of estrogen biosynthesis.
1-Methyl-1,4-androstadiene-3,17-dione (SH 489) was characterized as a competitive and irreversible inhibitor of human placental aromatase. The compound and the principal predicted metabolites show no endocrinological side effects suggesting that SH 489 should be suitable as a prototype drug for treatment of estrogen-dependent disease states.
Androstenedione↗
Aromatase inhibitors and benign prostatic hyperplasia.
A growing amount of evidence implies that estrogens may play a role together with androgens in the genesis of benign prostatic hyperplasia (BPH) in man. We review here some of this evidence together with advances made in characterizing inhibitors of estrogen biosynthesis (aromatase inhibitors). It is proposed that aromatase inhibitors may find application in non-surgical treatment of BPH.
Androstenedione↗
[Synthesis of Diflucortolon and its esters].
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Pregnadienediols↗
[Microbiological saponification of substituted 1-dehydrocorticosterone-21-trimethyl acetates].
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Acetates↗
[Blocking of the microbiological 11 beta-hydroxylation of steroids by 18-methyl substitution].
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17-Hydroxycorticosteroids↗
An abnormal ring cleavage of lalpha,2alpha-epoxy-3-keto steroids by hydrogen fluoride.
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Androstanes↗
[On the synthesis of ecdysones].
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Ecdysone↗
The synthesis of ecdysome.
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Chemistry, Organic↗
[Synthesis of ecdysone. 3. On insect hormones. Syntheses of 2-beta, 3-beta, 14-alpha-trihydroxy-6-keto-delta-7-A-B-cis-steroids].
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Chemical Phenomena↗
[On the synthesis of ecdysone. IV. On insect hormones. The synthesis of the natural skin shedding hormone].
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Chemistry, Organic↗
[1,2-beta-methylene steroids].
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Chemical Phenomena↗
Configuration and conformation of the A-ring of 1-methyl steroids.
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Chemical Phenomena↗
Ecdysone catabolism in the white mouse.
Ecdysone metabolism was investigated in the white mouse Mus musculus. It was shown to involve dehydroxylation at C-14, followed by reduction of ring B into a 6 alpha-hydroxy derivative and epimerization at C-3.
Animals↗