Biomedical subjects

U Koerner

Publications and source records attributed to U Koerner.

3 recordsLinked to original sources

PubMed1977

Diabetic retinopathy study. Data acquisition and its reliability.

The documentation of ophthalmologic data of patients with diabetic retinopathy (DR) is described. Special attention has been paid to the standardized grading of opacities of the dioptric media as well as to the assessment of classified arteriolar abnormalities. The reproducibility of these judgments was determined by a double evaluation test. The reliability of the assessment of classified retinal lesions on panorama fundus photographs was reported elsewhere. A further section of the questionnaire that concerns the documentation of the patient's history, of general medical and laboratory findings, and of reasons why individual patients "drop out" from the study, is described in this contribution.

Animals↗

PubMed1976

Diabetic retinopathy study. Assessment and comparison of retinal lesions for computer analysis.

A method of documentation of a diabetic retinopathy (dR) is described. Panorama fundus photographs (PPhs) of each eye are taken every 3-6 months. The retinopathy is classified according to qualitative, quantitative, and topographic criteria. The retinal lesions are assessed according to a subjective grading scale. Data of direct readings and of comparisons between two PPhs of one eye are transferred to punch cards for storage and computer processing. In a double evaluation of 200 PPhs, the overall reliability of readings was found to be approximately 95%.

Diabetic Retinopathy↗

PubMed1976

Diabetic retinopathy study. Preliminary results from 215 patients treated uniocularly with photocoagulation.

Preliminary results of a controlled study on diabetic retinopathy are reported. Two hundred and fifteen patients with proliferative (PDR) and nonproliferative (NPDR) retinopathy were uniocularly treated by Xenon photocoagulation and followed for a minimum of 6 months--6 years. Intra- and epiretinal new vessel formations (RNF) decreased in treated but increased in untreated eyes at a high statistical significance. A transition of background retinopathy into the proliferative stage was significantly retarded after photocoagulation. An improvement of new vessel formations on the disc (DNF) was not evident after 3 years of follow-up. The progression of preretinal neovascularization (PRNF) was significantly reduced only for 1--2 years after treatment. The incidence of massive vitreous hemorrhages, however, which showed the highest quotient of contingency with PRNF was much lower in treated eyes also after 3 years. The difference was significant only in extensively photocoagulated eyes with more than 100 lesions on average. The effect of photocoagulation on diabetic maculopathy with preservation of a useful visual acuity was highly significant only in diabetics under 60 years of age, the effect increasing with time as the control eyes fared worse. By contrast, in patients over 60 years of age, the course of maculpathy was not influenced, and a linear decrease of visual acuity occurred in both treated and untreated eyes.

Age Factors↗