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Biomedical subjects

U Krusche

Publications and source records attributed to U Krusche.

5 recordsLinked to original sources
PubMed1995

[Microbial contamination of immersed massage devices].

Investigations in the District of Schaumburg. On the occasion of the inspection of a hospital we became aware of the problem of contamination of underwater-massage tubs with microorganisms. Hence, investigations according to the German DIN standard 19,643 were performed on 41 tubs. Very often we found a high count of microorganisms. If Pseudomonas aeruginosa was detected, the use of the respective tub was prohibited because of the risk of infection (about 70% of all tubs). The reasons are the design of the pumps and different procedures of cleaning and disinfection. During the investigations the suppliers of the apparatus were queried. In some cases, technical improvements have already been effected. Reliable standard disinfection procedures must be developed.

Colony Count, Microbial↗
PubMed1993

Antibodies to retrovirus proteins in scleroderma.

In 8 out of 29 patients with scleroderma we found antibodies to HIV retroviral proteins in the Western blot analysis. The sera reacted only to one or two of the following bands: p 18, p 24, p 55, p 65 in relatively weak grades. There were no evident clinical correlations with the reactivity of certain bands, nor signs of direct HIV infection in our patients. Apart from 3 cases with positive CMV reactivity (IgM), there was no cross-reactivity to HTLV I or EBV (IgM) and to topoisomerase (Scl 70) or other autoantibodies to various nuclear antigens related to scleroderma. It is not clear whether retroviruses are involved in the pathogenesis of scleroderma or whether these antibodies are due to molecular mimicry.

Adult↗
PubMed1993

[Vascular function parameters in idiopathic and quartz-induced progressive scleroderma].

In 15 patients with systemic sclerosis (SS) and 8 patients suffering from silicosis and/or silica dust exposure-associated scleroderma (SAS), various parameters of endothelial cell and platelet function and of blood coagulation and fibrinolysis were studied. In 9 of the 23 patients the values for the von Willebrand factor antigen were increased, and the same applied to the endothelin levels in 8 of 23 patients. Protein C, protein S, anti-thrombin III and tissue plasminogen activator (before and after 10 min venous occlusion) were normal. The plasminogen activator inhibitor, however, was increased in 5 patients. Increased levels of platelet factor 4 and of beta-thromboglobulin were found in 20 patients, while the ADP- and epinephrine-induced platelet aggregation was reduced in 5 patients. No individual patient was found to have a general disturbance of all parameters. The deviations in the parameters of endothelial cell and platelet function and of blood coagulation and fibrinolysis proved to be rather inconsistent. This suggests different functional stages in dependence on the various influential factors. There was no close correlation either with the severity of Raynaud's phenomenon or with the type of SS. In addition, there were no basic differences between SS and SAS. The disturbances occurred with similar frequency and in similar proportions in both disease groups.

Adult↗
PubMed1993

[Antibodies to retroviral proteins in progressive scleroderma].

In 8 out of 29 patients with scleroderma we found antibodies to HIV retroviral proteins in the Western blot analysis. The sera each reacted only to one or two of the p 18, p 24, p 55, and p 65 bands, and the reactions were relatively weak. There were no evident clinical correlations with the reactivity of certain bands and signs of direct HIV infection in our patients. Apart from three cases with positive CMV reactivity (IgM) there was no cross-reactivity to HTLV I or EBV (IgM) or to topoisomerase (Scl 70) or other autoantibodies to various nuclear antigens related to scleroderma. It is not clear whether retroviruses are involved into the pathogenesis of scleroderma or whether these antibodies are due to molecular mimicry.

Antibodies, Viral↗