Biomedical subjects
Publications and source records attributed to U Lagler.
A 66-year-old male developed lymphocytic alveolitis with bronchiolitis after 3 month's treatment with mesalazin for ulcerative colitis. The patient's symptoms disappeared after halting mesalazin and increasing the steroid dose, the reduced diffusing capacity ameliorated and the thoracic X-ray normalized. The question whether this was a case of pulmonary involvement in inflammatory bowel disease or a drug side effect.
We describe 3 cases of eosinophilic pneumonia of unknown etiology with atypical clinical findings diagnosed by bronchoalveolar lavage (BAL). In 2 patients with subacute symptoms and restrictive ventilatory dysfunction there was no eosinophilia in peripheral blood, and chest X-ray showed a bilateral acinar and mixed interstitial-acinar pattern respectively. Transbronchial lung biopsies revealed only nonspecific changes. The third patient had acute respiratory failure and the eosinophils in peripheral blood were 1500/microliters. Chest X-ray demonstrated only minimal interstitial changes. In all instances the eosinophilic pneumonia was diagnosed by a marked BAL-eosinophilia of 25 to 45%. No specific etiology could be detected for the eosinophilic lung disease. The response to treatment with corticosteroids was prompt.
A 49 year old woman treated for metastatic adenocarcinoma of the breast suddenly developed the symptoms of acute pulmonary edema 90 minutes after infusion of mitomycin C/vinblastine. No other causes of dyspnea were found. This dangerous side effect of mitomycin C/vinblastine therapy has been described previously. The appearance of dyspnea after the injection of vinblastine in patients treated with the above-mentioned drug combination should always be considered an alarming symptom.
Specimens from the lower airways were taken by protected brush catheter during 54 fiberoptic bronchoscopies for quantitative microbiological analysis. This technique allows uncontaminated sampling of lower airway secretion. The chance of identifying a bacterial pathogen in patients who have already been treated with antibiotics was less than 10%. The method is cumbersome, and it is important not only to culture but also to quantify the bacteria. The microbiological results thus obtained have influenced clinical decision-making in only a few patients.
We describe a 35-year-old woman who developed pulmonary edema at 38 weeks of pregnancy as a result of upper airway obstruction caused by a progressively enlarging euthyroid goiter.
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Systolic blood pressures of 72 normal newborn infants were taken immediately, as well as 60, 120, 240 and 360 min after birth, using the transcutaneous Doppler ultrasonic technique. The mean values lie between 56 +/- 9 and 61 +/- 9 mm Hg and are presented graphically. This method is recommended for routine use in the delivery room.
A case of malacoplakia of the prostate in a 66-year old man is reported. This is the first time, that the diagnosis was established by needle biopsy. There are only eight previous reports of prostatic involvement. Three of these cases were initially misinterpreted as carcinoma. The present case is discussed in view of the pertinent clinical and pathological data in the literature.