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Biomedical subjects

U Lasson

Publications and source records attributed to U Lasson.

At least 19 recordsLinked to original sources
PubMed1985

Radiotherapy of non-metastatic ewing sarcoma.

Comparing the radiotherapy data of two groups of patients with non-metastatic Ewing sarcoma, we came to the following conclusions: intensive chemotherapy does not substitute for effective radiotherapy. Irradiation fields should be large enough to include the whole affected bone and the entire extra-osseous compartments, exempting only uninvolved epiphyses. Marginal recurrences are a major risk of the shrinking field technique. Single doses per fraction should be high and the total dose raised to the point of maximal irradiation tolerance of normal tissues.

Adolescent↗
PubMed1985

Ophthalmoplegic neurolipidosis--storage cells in heterocygotes.

We describe two children with ophthalmoplegic neurolipidosis. Bone marrow specimens of the patients and their healthy relatives disclose typical storage cells. The literature is reviewed. The storage cells in healthy relatives are interpreted as a sign of heterocygosity.

Biopsy↗
PubMed1985

Improved treatment results in childhood acute myelogenous leukemia: a report of the German cooperative study AML-BFM-78.

One hundred fifty-one children with acute myelogenous leukemia (AML) entered the cooperative study BFM-78 between December 1978 and October 1982. The initial therapy consisted of an intensive induction and consolidation regimen over eight weeks with seven different drugs and cranial irradiation. It was followed by maintenance with thioguanine and cytosine arabinoside for two years and additional Adriamycin during the first year. One hundred nineteen (79%) patients achieved a complete remission. Thirteen (9%) children died of early hemorrhages. After a median follow-up time of 36 (12 to 57) months, 47 relapses have occurred, with CNS involvement in seven cases. The life table analysis revealed a probability for overall survival after almost five years of 45% (SD, 4%), for event-free survival 41% (SD, 4%), and for the event-free interval 52% (SD, 5%). Up to now, no relapse was seen after 2 1/2 years. Risk factor analysis showed that early fatal hemorrhages occurred predominantly in children with M5 FAB type and with initial leukocytosis. An initial high WBC count and liver enlargement were unfavorable parameters for achieving remission. No factors could be identified concerning the risk for relapse. These data indicate that the applied treatment strategy is successful in inducing complete remissions in about three fourths of children with AML and also in enhancing considerably the chances for long-term remission.

Adolescent↗
PubMed1984

[Aggressive fibromatoses].

Benign by nature, aggressive fibromatoses (desmoid fibromas) may represent as difficult therapeutic problems as malignant tumours. When subtotally resected they tend to recur. But spontaneous regression is possible. Expense and limits of their surgical treatment are discussed with reference to seven patients. In five cases primary affliction of bone was evident. There are three reports given in detail: In the first, malignant transformation may be due to radiation therapy and hemipelvectomy could not prevent recurrence. In the second, spontaneous regression of untreated pelvic affection may have occurred. In the third, several resections and amputation of the leg failed to cure congenital infantile fibromatosis.

Adolescent↗
PubMed1983

The snuff-induced lesion. A clinical and morphological study of a Swedish material.

Snuff-induced oral lesions were studied clinically, histologically and by electron microscopy. The material was collected from 21 male snuff users. The lesions had a characteristic whitish appearance with a wrinkled swollen texture and the most common localization was in the vestibular area of the upper jaw. In two cases gingival retraction was observed. The light-microscopical examination showed a mild epithelial dysplasia in five cases. No carcinoma in situ or invasive carcinoma was recognized. In some of the cases ultrastructural changes in the basement lamina region, such as defects of the basement lamina and the occurrence of basal cell processes in the connective tissue, were observed. Odland bodies were seen in the epithelium. In the connective tissue filamentous material of unknown nature was found. The ultrastructure of the filamentous material suggested that it might be amyloid. In summary, snuff-induced lesions should be diagnosed, patients should be informed and made to quit the habit, and remaining lesions should be followed up regularly.

Adult↗
PubMed1982

[Vitamin and zinc levels in leukemic children during induction therapy (author's transl)].

In 23 leukemic patients treated according to the West Berlin-protocol, we studied prospectively the plasma levels of the vitamins A (and carotinoids), B1, B2, B6, C, and E, as well as serum zinc values. Blood was drawn on days 0 (before treatment), 15, 29, and 57 of induction therapy. With one exception, plasma vitamin levels did not change significantly during treatment; however, vitamin A increased in the first and decreased in the second phase of induction (p less than 0.01) without clinical signs or symptoms. The serum levels of zinc (p less than 0.05) and the alkaline phosphatase fell continuously from day 0 to 29, but there was no correlation between these two parameters in the same patient. Clinical symptoms of zinc deficiency were not observed. We conclude: 1) That plasma vitamin levels in this limited population are generally unaffected by the underlying malignant disease, the aggressive therapy and altered feeding behaviour, and 2) that the significant decrease of serum zinc does not play a major role in the expression of clinical and biochemical side effects of cytotoxic therapy.

Adolescent↗
PubMed1981

Congenital erythroleukemia. A case report.

The disease of a four week old boy is described, which presented with papulous skin infiltrations, lethargy, anemia and bilateral testicular swelling. The investigation of bone marrow, cerebrospinal fluid and skin biopsy revealed infiltration by a leukemic process which could be identified by means of cytology and cytochemistry as erythroleukemia at the stage of erythremic myelosis. Death occurred 20 days after the onset of symptoms. Only one previous report of congenital erythroleukemia could be found in the literature. The findings are briefly discussed.

Biopsy↗
PubMed1981

[Evidence that electrophoretic-mobility (EM) test is of no value for the diagnosis of cancer in children (author's transl)].

After incubation with encephalitogenic factor (EF) the capacity of lymphocytes to inhibit the migration of tanned, stabilized sheep-erythrocytes in the electric field was tested in 133 children (52 tumor- and 81 control patients). Tumor patients (on and off treatment) as well as children suffering from non-inflammatory diseases showed a significant migration inhibition as compared with healthy controls (p less than 0.05). However, in only 3/23 patients on, and 3/35 off therapy, an unequivocal inhibition of more than 8% could be demonstrated. The repeated examination of 8 individual patients yielded an unsatisfactory reproducibility; results were independent of the EF concentration ranging between 200-600 microgram EF/ml. We think that the EM-Test provides no useful information for the detection of malignant disease in children.

Adolescent↗
PubMed1978

Osteogenic sarcoma complicating osteogenesis imperfecta tarda.

We describe the case history of a 13 years old boy who developed osteogenic sarcoma of the left thigh, six years after diagnosis of osteogenesis imperfecta tarda with a positive family history. Only four other patients with this disease combination are reported in the literature. Preoperative treatment with high-dose Methotrexate caused marked tumor regression, as shown at examination of amputation material. The inter-relationships between the two disorders are discussed and the literature is briefly reviewed.

Adolescent↗
PubMed1977

[Agranulocytosis due to cotrimoxazole in a seven-year-old boy (author's transl)].

A seven-year-old boy presented with agranulocytosis after receiving cotrimoxazole for eight days. Three years previously he had had another episode of untoward reaction to the drug with transient, mild leucocytopenia. But four periods of cotrimoxazole treatment in the intervening years had been tolerated without complications. There was no improvement in the critical state of the child while on broadspectrum antibiotics, until granulocytes reappeared in peripheral blood. This reaction to cotrimoxazole, although extremely rare, requires serial white blood cell and granulocyte counts during repeated and prolonged cotrimoxazole administration, if signs or symptoms of infection persist.

Agranulocytosis↗