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Biomedical subjects

U Lauper

Publications and source records attributed to U Lauper.

22 records · Page 2Linked to original sources

[Pregnancy and delivery in a mother with Ebstein's anomaly].

Ebstein's anomaly is characterized by abnormalities both in the basal and in the free attachments of the leaflets of the tricuspid valve. Fairly frequently the developmental defect is associated with a WPW syndrome (Type B). The main obstetric problems arise from tachyarrhythmias. Since tachycardias in these patients are due to physical stress, correct planning of delivery calls for lightening of the hemodynamic burden of labor, careful analysis of the cardiac status, meticulous preparation for optimum antiarrhythmic therapy and correct timing for induction of labor. The case of a young primipara with Ebstein's anomaly is presented to typify the need for cooperation of subspecialities.

Adult↗

Normal placental function and fetoplacental blood circulation in advanced abdominal pregnancy.

Normal levels of unconjugated estriol and human placental lactogen hormone in the maternal serum and a normal, reactive pattern of non-stress test cardiotocography were recorded in a case of advanced abdominal pregnancy with surviving newborn. The placenta was inserted at the base and side walls of fossa Douglas. Fetal, umbilical and retroplacental arterial Doppler ultrasound examinations revealed normal velocity waveforms. These findings indicated that the trophoblast invasion to the retroplacental arteries also occurs when the placenta has an extra-uterine insertion, and this can result in a normal placental blood supply and function.

Adult↗

[Premature labor in HIV infected women. Swiss "HIV and Pregnancy" Study Group].

In the Swiss Study "HIV and pregnancy" we observed 153 singleton pregnancies of HIV-positive women. 23 (15%) of those ended with a premature delivery. For drug addicts (n = 100), the incidence of prematurity, 20%, significantly higher than in those free of drugs (n = 53) with 5.6%. The most frequent cause of prematurity was premature labor or rupture of the membranes (n = 13), followed by maternal illness (n = 8) and fetal complications (n = 2). Women with premature delivery tended to have lower CD4 cell counts than those with term delivery (29.4% vs 12.0% with < 200 CD4 cells/microliters). Low CD4 cell counts and drug consumption are two independent but cumulative risks for severe infections. 16 of the 153 women (12 with, 4 without drug consumption) had severe infections during pregnancy; in 4 cases (25%), this led to prematurity. The most common infection was pneumonia (14/16), further one case of pyelonephritis and one of cerebral toxoplasmosis. Two of these 16 infants (12.5%) were HIV-positive. We could not confirm a relationship between prematurity and vertical HIV transmission. Of the HIV-classified children, 3/18 (16.7%) premature infants and 16/74 (21.6%) term infants were infected.

AIDS-Related Opportunistic Infections↗