Intramitonchondrial crystalline inclusions in metastatic hypernephroma of the liver.
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Biomedical subjects
Publications and source records attributed to U Lewinski.
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Electron microscope examination of the liver biopsies of 33 patients revealed the presence of intramitochondrial crystalline inclusions (IMCI) in ten of them. Three patients suffered from iron deficiency anemia, porphyria, and malignant melanoma, conditions not reported to be associated with IMCI. Comparison of the clinical and laboratory findings of patients with and without IMCI did not show significant difference, or a clue for clarifying the nature of this phenomenon. Although these inclusions were reported in normal individuals, the possibility that they are the result of liver damage is not excluded.
The case history of a patient treated with dipyridamole who developed severe epistaxis, accompanied by alteration of the platelet aggregation tests, is presented. The bleeding did not respond to local therapy and stopped only after discontinuation of the drug and normalization of the platelet aggregation. Hemorrhage, especially in elderly patients, should be considered as a possible complication of dipyridamole administration.