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Biomedical subjects

U Möller

Publications and source records attributed to U Möller.

54 records · Page 3Linked to original sources
PubMed1979

Synthesis of arachidonic acid in the human placenta in vitro.

The syntheses of arachidonic acid and total fatty acids were measured in human placentas at the end of the first trimester and at term using 14C-acetate in in vitro incorporation experiments. The rates of arachidonic acid synthesis were determined to be 0.70 (first trimester) and 0.64 (term) mumol/h/100 g of placental tissue. The calculated rates of total fatty acid synthesis amount to 0.5 (first trimester) and 0.6 (term) mumol palmitate-equivalents/h/100 g. The results suggest that the human placenta seems to be not dependent on maternal arachidonic acid. Near term the placenta even could be source of arachidonic acid.

Arachidonic Acids↗
PubMed1979

Oxidation and synthesis of fatty acids in human and rat placental and fetal tissues.

The rat fetus (day 21 of pregnancy) covers its fatty acid (FA) demands at equal amounts both by maternal-fetal FA transfer and fetal FA synthesis. At the end of the first trimester the human fetal FA synthesis is too small to cover the fetal FA requirements. Therefore, the transfer of FA from the mother to the fetus seems to be the predominant source of fetal FA. The FA oxidation is greater than the FA synthesis in human and rat placenta as well as in the human fetus at the end of the first trimester, whereas the rat fetus (day 21 of pregnancy) oxidizes and synthesizes FA at equal amounts.

Animals↗
PubMed1975

[The problem of heparin therapy in suspicion of intrauterine retardation].

From 19 with Heparin treated patients by suspicion of intrauterine retardation 12 patients were investigated relative to the physiology of coagulation. The placentae were investigated morphologically. The treatment with Heparin was without danger. A certain effect of the efficiency by the treatment with Heparin we couldnt establish. The theoretical introductions relative to the efficacy of Heparin entitled the further application of this drug. We can hope, that a better selection of patients with intrauterine retardation by help of ultrasound and other methods (sequenzszintigraphy with In113m and electronmicroscopical procedures) are able to establish the favourable impression by the clinical use of Heparin.

Calcinosis↗
PubMedDate not supplied

Versatile procedure of multiple introduction of 8-aminomethylene blue into oligonucleotides.

The coupling of 8-aminomethylene blue to oligonucleotides via poly-L-glutamic acid linker using carboxy-anchor groups will be described. The introduction of carboxy-anchor groups into oligonucleotides proceeds both during automated synthesis using 6-(ethoxycarbonyl)hexyl 1-O-phosphoramidite and by reaction of 5'-amino-functionalized oligonucleotides with succinic anhydride. O-(N-Succinimidyl)-1,1,3,3-tetramethyluronium tetrafluoroborate was used as activating reagent for binding of poly-L-glutamic acid to the carboxylated oligonucleotides. The successful 5'-carboxylation and poly-L-glutamic acid coupling were proven both by polyacrylamide gel electrophoreses and HPLC. 8-Aminomethylene blue in its leucoform was covalently coupled to the oligonucleotides in the presence of water soluble carbodiimide.

Base Sequence↗
PubMedDate not supplied

[Nitroglycerin patch for tocolysis--a prospective randomized comparison with fenoterol by infusion].

OBJECTIVE: To evaluate tocolytic efficacy of transdermal glyceryl trinitrate (GTN) in comparison to fenoterol per infusionem in a prospective randomized multicenter study. PATIENTS AND METHODS: 50 pregnant women between 27 and 35 weeks of gestation with preterm labour were treated with either GTN patches (0.4-0.8 mg/h) or fenoterol per infusionem (60-120 micrograms/h) up to stop of contractions or 35 weeks in maximum. The primary outcomes were the prolongation of gestation by 48 h, 7 days or up to 37 weeks of gestation as well as the neonatal outcome. The progression of cervical ripening and maternal side effects during tocolysis were assessed as secondary outcome criteria. RESULTS: There was no difference in successful tocolysis for 48 h and 7 days in both groups, whereas significantly more women passed 37 weeks after GTN therapy. So mean duration of pregnancy, birth weight and height were greater, whereas transfer into neonatal care unit was significantly rare after GTN. There were no differences in neonatal outcome and progression of cervical ripening during tocolysis. Maternal side effects during GTN were fewer and weaker compared with fenoterol. Circa 70% of GTN treated women had a headache temporary, whereas more than 90% of the patients with fenoterol suffered from tachycardia and tremor. CONCLUSIONS: Tocolytic efficacy of transdermal GTN was at least equivalent to the established beta-mimetic therapy with fenoterol. Because of the lower preterm delivery rate transfer into neonatal care for control was significantly rarer after GTN with equally good neonatal outcome in both groups. Beside the headache transdermal GTN therapy had lower maternal side effects in comparison to fenoterol.

Administration, Cutaneous↗
PubMedDate not supplied

[Current aspects of the Thuringia prematurity prevention campaign 2000].

In two prospective investigations the effectiveness of the self- care program for prematurity prevention, developed by Saling, was investigated. Pregnant women in Erfurt have been offered to perform self-measurements of their vaginal pH by means of test gloves (Careplan VpH) twice a week. The women were instructed to see their physician immediately, if abnormal values (pH > or = 4.7) or other risk factors were present. 73 out of 381 women in the intervention group have been identified as risk cases. 58 of them were treated with a lactobacillus preparation, and 24 with clindamycin cream for bacterial vaginosis, 3 patients refused to have any therapy. In this study the prematurity rate was 8.1 % in the self-measurement/intervention group vs. 12.3 % in the control group (N=2 341, P < 0.05); 0.3 % vs. 3.3 % of the neonates belonged to the group of early prematures with a gestational age of < 32 + 0 weeks (P < 0.01). PROM was registered in 22.8 % vs. 30.8 % (P < 0.001) respectively. Starting March 1, 2000 a similar statewide pH-screening program was initiated in Thuringia. According to the study design a significant decrease of prematurity was hypothetically expected for the second half of the year 2000. In Erfurt an overall decrease of prematurity from 7.68 to 6.81 % and a reduction of cases < 32 + 0 weeks from 3.22 to 2.39 % was observed (N=1,600). Data from 16,276 women are available for the state of Thuringia. On this basis a significant reduction of early prematurity from 1.58 to 0.99 % was seen respectively (P < 0.001). Comparing low birthweights a significant reduction of cases was achieved as well in all groups. On the basis of the data obtained we recommend the extension of the campaign in the whole of Germany.

Female↗
PubMedDate not supplied

[Fetal movement and acceleration behavior in unimpaired and impaired newborn infants].

The following biophysical examination parameters were found by CTG-synchronous registration of fetal body and respiratory movements and compared in 7 fetuses impaired at birth (pHa less than 7.20, 1- and 5-minute Apgar scores less than or equal to 7 points) and 76 unimpaired born fetuses (pHa greater than or equal to 7.20, 1- and 5-minute Apgar scores greater than or equal to 8 points): number of fetal body movements per 10 minutes examination time; total and mean durations of these movements per 10 minutes; number of fetal respiratory movements per 10 minutes; number and total duration of fetal respiratory movement periods per 10 minutes; frequency of fetal respiratory movements; proportion of 10-minute periods with and without fetal body and/or respiratory movements and the amounts of the quotients from the amplitude of accelerations in fetal heart rate resulting from fetal body movements and the durations of these body movements. The mean interval between biophysical examination and childbirth was 11 days. Principally, the impaired born fetuses were less active in their movements than were unimpaired born fetuses. Apart from the frequency of fetal respiratory movements and the proportion of 10-minute periods without fetal body movements, the above mentioned parameters differ significantly with a probable error of alpha = 0.05. All biophysical parameters were registered on an uterus without labour and the cardiogram as well as the biophysical profile--with the exception of one fetus from the group of impaired borns--being unremarkable. The 10-minute periods without fetal body or respiratory movements were excluded from analysis.

Apgar Score↗
PubMedDate not supplied

[Movement and acceleration behavior of eutrophic and hypotrophic fetuses sub partu].

Cardiogram synchronous registration of fetal body and respiratory movements (real-time ultrasonic examination) was employed to compare the movement and acceleration behaviour of 130 normotrophic fetuses to that of 13 fetuses with body weights between the 6th and the 10th weight percentiles according to Kyank and of 13 fetuses with body weights less than or equal to the 5th percentile. The mean duration of examination was 80 minutes. The normotrophic fetuses exhibited the highest movement activity and reactivity of the cardiovascular system. In 88.6%, accelerations of fetal heart rate were associated with fetal body movements and were independent of fetal weight. Comparison with a previous communication of the authors revealed that intranatal fetal movement activity and reactivity of the cardiovascular system were only slightly below that with a uterus without labour. The only exception were fetal respiratory movements with significantly fewer intranasal observations.

Cardiotocography↗
PubMedDate not supplied

[Methodologic problems and initial results of synchronous CTG computer-assisted registration of fetal movements by ultrasound].

Aim of the studies is the registration of latent criteria of hypoxia in fetuses with intrauterin growth retardation diagnosed by ultrasonography. Under standardized conditions, 19 pregnant women with hypotrophic and 20 with eutrophic fetuses were examined between weeks 36 and 40 of gestation. Concomitantly, fetal body and respiratory movements as well as the antenatal phonocardiotocogram were registered. The following apparatuses were used (fig. 1): ultrasound unit "sono Diagnost R" from Philips, FRG; six-channel recorder "6 NEK 401" from VEB Kombinat Messgerätewerk Zwönitz, GDR; lab-oriented computer "K 1520", VEB Kombinat Robotron Dresden, GDR; fetal monitor "MT 810" (with autocorrelation) from Toitu Co., LTD, Tokyo, Japan; There were close correlations between fetal body movements and accelerations in the cardiogram. The duration of the fetal body movements influenced the duration as well as the amplitude of the corresponding accelerations. A. comparison between the two groups examined reveals that these medium term changes in the heart rate were less marked in the hypotrophic fetuses than in the control group. The differences between the two groups were statistically significant (fig. 2, 3, 4, 5). Fetal respiratory movements influence the range of beat-to-beat-variability in the cardiogram. In the group of hypotrophic fetuses this range increased significantly by 1.4 bpm during one segments of respiratory movement. For the group of eutrophic fetuses the increase in the range of beat-to-beat-variability was 1.8 bpm. We did not find a significant difference between both groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗
PubMedDate not supplied

[Fetal movement and heart acceleration behavior in eutrophic and hypotrophic fetuses in the 36th to 40th week of pregnancy].

By means of combined ultrasonic and cardiographic monitoring, the movement and acceleration behaviours of 44 eutrophic fetuses were compared to those of 19 fetuses with body weights between the 6th and 10th weight percentiles according to Kyank and to 21 fetuses with body weight not greater than the 5th weight percentile. The eutrophic fetuses moved more frequently and--related to 10 minutes examination time--over longer total periods than did the fetuses with intrauterine growth retardation. The longest mean duration of isolated fetal movement, however, was observed in the hypotrophic fetuses. With regard to fetal resting and activity stages, the highest percentage (10%) of fetal resting stages was found in the fetuses less than or equal to the 5th weight percentile. 93% of all accelerations in fetal heart rate obviously resulted from fetal movements, duration and amplitude of the accelerations depending on the duration of fetal movements. The degree of heart rate responses to fetal movements was different in the three groups examined. Standard weight fetuses responded most intensively. The percentage of fetal movements resulting in accelerations was highest (76%) in the group of the eutrophic fetuses as well. The mean duration of acceleration was most marked in the group of fetuses less than or equal to the 5th weight percentile (32.8 sec) and so was the mean acceleration amplitude in the normotrophic fetuses (19.7 bpm). Decelerations following accelerations in fetal heart rate did not differ in the three groups examined with regard to their number, amplitude and duration.

Female↗