The cyclosporin related toxicity in high risk liver transplant patients.
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Biomedical subjects
Publications and source records attributed to U Maggi.
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In order to evaluate the incidence of postoperative surgical complications requiring additional surgery, we report 73 consecutive liver orthotopic transplantations performed in 60 patients from June 1983 through June 1989. Transplantations were performed in 54 adults and 6 children for the following reasons: postnecrotic cirrhosis in 31, biliary diseases in 16, hepatobiliary malignancy in 7; Wilson's diseases in 3 and fulminant hepatitis in 3. Surgical complications requiring additional surgery occurred in 35 (58%) patients with 53 operations. Twenty-two patients (36%) had postoperative bleeding complications, 5 (8%) biliary complications, one had a late artery thrombosis and 16 (26%) had miscellaneous complications. The latter group included 6 abdominal hernias, 3 bowel perforations, 2 bowel obstructions, 2 cases of pneumothorax, 2 cases of chylous ascitis, one liver necrosis, one hepatic artery kinking, one peritonitis and one cardiac tamponade. The incidence of surgical complications was not significantly different in patients who underwent retransplantation as compared to those who had a single transplantation. We did not find a significant difference in surgical complication rate according to the preoperative liver disease. In comparison with the literature, in our series, we had a higher rate of abdominal hernia but a lower rate of biliary complications.
In Italy, many patients with B-virus (HBV) and Delta-virus (HDV) end-stage liver disease, are potential candidates to liver transplantation. Several authors have reported 70 to 100% hepatitis recurrence rates. From june 1983 to may 1989, 72 transplants on 60 patients were performed at Liver Transplantation Department of the Maggiore-Policlinico Hospital of Milan. The results in 26 HBsAg positive patients (19 with HDV infection), that underwent liver transplantation, are reported. A detailed report of 17 of these patients with a follow-up longer 7 months, and the clinical course of 4 patients with HBV reinfection, 3 of which had hepatitis recurrence, is also presented. The occurrence of HDV-RNA in the serum of 5 patients, that were negative for HBsAg and also other HBV-HDV replication markers after transplantation is discussed, together with the observation that in these patients no hepatitis recurrences or alteration of the clinical course were evident.
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Thirty-eight patients with carcinoma of the bile ducts were studied by PTC and ERCP. These instrumental procedures permit at present a precise and complete diagnosis. In 22 cases (57.9%) the association of a lithiasis was evidenced. The application of a percutaneous transhepatic drainage after PTC in cases of stricture furtherly supports the diagnostic accuracy by the cytologic examination and culture of the bile collected from drainages.
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The article provides a synthetic review of the most current problems of treatment of acute respiratory insufficiency refractory to standard and conventional therapeutic remedies using extracorporal membrane gas exchangers. On the basis of a review of the literature on the subject, the advantages and disadvantages of each main type of oxygenator are considered and critically evaluated with regard to metabolic, haemodynamic and circulatroy activity and the repercussions of each resuscitation technique on haemocoagulation.
A study was made of anesthesiological and resuscitation problems in 18 patients suffering from drepanocytic anemia. An examination of the results showed that the anesthesiological problems do not so much concern selection of the anesthetic as a knowledge of the physiopathology of this disease, i.e. the tendency to bronchopulmonary complications as a result of the increased viscosity of the blood, the increased mechanical fragility of the erythrocytes, and erythrostasis, with consequent rise of ischaemic necrosis and damage to the various parenchymas. It was also observed that pulmonary complications occurred more frequently in preoperatively transfused patients.
The indices of renal functionality are studied during the course of ether anesthesia in order to ascertain the behaviour of the kidney subjected to narcosis with this drug. A sharp reduction in the minute volume of F.G. and P.R.E. is evidenced, together with an increase in renal resistances, especially as regards the efferent sector. These changes, which are established at the start of anesthesiological treatment, tend to decrease in intensity as narcosis continues. This picture is interpreted as being due to the concomitant action of two factors: a decrease in cardiac output on the one hand, and an increased incretion of catecholamines leading to renal arteriolar vasoconstriction on the other.
The rebreathing technique was used to study the behaviour of the circulatory flow in patients operated under ether anesthesia. It was observed that during ether narcosis the circulatory flow values show a fair drop at the readings made 30' and 45' after the inductive period. 60' after the start of ether narcosis the circulatory flow values show a tendency to increase, and these observations are accentuated in the readings taken at 75' and 90'.