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Biomedical subjects

U Merrild

Publications and source records attributed to U Merrild.

15 recordsLinked to original sources
PubMed1989

Subcutaneous joint-mouse escape during knee-joint arthroscopy.

During arthroscopy of the knee, large volumes of fluid are required. Cadaver studies have indicated that flexion of the knee may cause rupture of the joint capsule during arthroscopy. To illustrate this, a rare case is presented with rupture of the posterior part of the capsule during arthroscopy with extrusion of a joint mouse. This possibility should be considered when the joint mouse cannot be found inside the joint during arthroscopy.

Adult↗
PubMed1989

Amyloid deposits in surgically removed articular and periarticular tissue.

In tissue from 13 of 30 patients subjected to meniscectomy, amyloid degeneration was found to varying extent along the surface of the meniscus. Tissue from 30 synovectomies, 30 bursectomies and 30 ganglia showed amyloid deposits in four, six and eight cases, respectively. Amyloid was found significantly more frequently in older patients, but there was no sex difference and no relation to duration of the symptoms or to other histological changes in the tissue. Micro-deposits of amyloid in joint tissue and tissue neighbouring joints are a frequent finding, especially in elderly persons, but the clinical significance of this finding is not clear.

Adolescent↗
PubMed1985

Topical ampicillin in addition to a systemic antibiotic prophylaxis in elective colorectal surgery. A prospective randomized study.

Prophylactic use of topical ampicillin in addition to intravenous ampicillin and metronidazole was studied in a randomized trial including 203 consecutive patients undergoing elective colorectal surgery. All received ampicillin, 1 g X 3, and metronidazole, 0.5 g X 3, intravenously for at least three days from induction of anesthesia, and 105 also received topical ampicillin, 1 g, in each of the surgical wounds. Deep wound infection or dehiscence was seen in 12 of 105 having both administrations of antibiotics, and in nine of 98 having only intravenous antibiotics. The two groups were similar according to distribution of sex, age, type of surgery, and efficiency of bowel preparation. Topical ampicillin should be omitted in elective colorectal surgery when systemic prophylaxis with ampicillin and metronidazole is used.

Administration, Topical↗
PubMed1981

Partial deletion of the short arm of chromosome 3.

A case of deletion of the short arm of chromosome 3 (46,XY,del(3)(p253) is described. The patient is a youth of 18 years in an institution for the mentally retarded. Phenotypically, he presents congenital heart disease, hypertelorism, ptosis, epicanthus, blepharophimosis, strabismus, nystagmus, synophrys, low-set ears, frequent infections, epilepsy (abnormal EEG and grand mal seizures), "rocker bottom" feet, flat occiput and muscular hypotonia. The parents are healthy and with normal karyotypes. A silent allele in the GPT system was found in the mother, the propositus and 4 of the 5 siblings.

Abnormalities, Multiple↗
PubMed1979

Sister chromatid exchanges in cultured peripheral lymphocytes from twins.

Sister chromatid exchange points (SCE points) on individual chromosomes were studied in cultured lymphocytes from 11 monozygotic (MZ) and nine dizygotic (DZ) same-sexed pairs by means of sequential Q-banding and BUdR-Giemsa techniques. No statistically significant variation between unrelated individuals with respect to SCE points on specific chromosomes was found. Intrapair differences in the number of SCE points on specific chromosomes were not significantly smaller between MZ twin partners as compared with DZ partners. The results suggest that genetic factors do not play any major role in the frequency and distribution of SCE in normal subjects.

Adult↗
PubMed1979

Prenatal diagnosis of polycystic kidneys and encephalocele (Meckel syndrome).

Two unrelated families are presented with repeated occurrences of a congenital syndrome of which the main stigmata were polycystic kidneys and occipital encephalocele (Meckel syndrome). Prenatal diagnosis, followed by interruption of pregnancy, was performed in one case. The diagnosis was based on an increase of amniotic alpha-fetoprotein (AFP), and on the mode of growth and cell types of cultured amniotic cells. In another similarly examined case the diagnosis was suspected, but the parents did not wish the pregnancy to be interrupted. The child was stillborn and malformed. AFP values are presented and discussed in relation to the observed malformations. Neural tube defects are associated with an increase of AFP in amniotic fluid, but, as in normal pregnancies, the values decrease with increasing gestational age. On the other hand, kidney malformations seem to be associated with AFP values which remain high or even increase with increasing gestational age.

Amniotic Fluid↗
PubMed1978

Anencephaly in trisomy 18 associated with elevated alpha-1-fetoprotein in amniotic fluid.

Elevated levels of alpha-1-fetoprotein (AFP) were found in the amniotic fluid of a 36-year-old woman in the 15th week of gestation. Because of this and the results of repeated ultrasonography, abortion was induced. An anencephalic fetus with trisomy 18 was delivered. The possible correlation among neural-tube defects, chromosomal abnormalities, and level of AFP is discussed.

Abortion, Therapeutic↗