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Biomedical subjects

U Metzler

Publications and source records attributed to U Metzler.

11 recordsLinked to original sources
PubMed1998

Blue filter amblyopia treatment protocol for strabismic amblyopia: a prospective comparative study of 50 cases.

PURPOSE: Previous studies of monochromatic visual evoked potentials confirm the strong suppression of (the cortical representation of) paracentral retinal areas of functionally amblyopic eyes, by a flat response to a blue stimulus. A clinical trial stimulating these areas with blue light was encouraging, and justified a prospective comparison of this treatment with conventional classic treatment. SUBJECTS AND METHODS: In 50 strabismic children with amblyopia, the blue filter treatment protocol (flash stimulation with, and the wearing of, a blue filter during occlusion of the better eye for one hour daily) was compared with the classical treatment (full time total occlusion by patch) in a prospective matched and randomized study. Patients 3 to 7 years old without previous treatment and a visual acuity up to 0.3 were admitted to the study. Visual acuity and fixation behavior were used as the parameters of comparison. Visual Evoked Potentials by monochromatic flashes were also studied. Results of treatment were compared after 6 months. RESULTS: The visual acuity outcome for the blue filter treatment was "statistically significantly" better (p=0.005). The greatest improvement was seen in the subgroup of children with eccentric fixation (p=0.01). Fixation behavior also showed a better outcome from the blue filter treatment (p=0.05) favoring especially children between 3 and 5 years. In children of this age with a visual acuity better than 0.1 we found a very "statistically significant" difference between the two treatments (p=0.004). In children 3 to 5 years old with poorer visual acuity we also found a "statistically significant" difference in the two treatments (p=0.04). The interocular difference of amplitude on the Visual Evoked Potentials also demonstrated more improvement in children treated with the blue filter. This treatment improved especially the cortical response to blue flash stimulation, correlating to paracentral retinal areas. CONCLUSIONS: The blue filter treatment protocol provided better results for treating amblyopia than the conventional classic occlusion treatment method. We propose that stimulation of these paracentral retinal areas triggers a better disinhibition of a functionally amblyopic eye.

Amblyopia↗
PubMed1989

[Treatment of metastatic adrenal carcinoma with suramin].

A right adrenocortical carcinoma (weighing 978 g) was removed from a 45-year-old man in April 1986, the tumour bed then being irradiated with 40 Gy. Subsequently discovered multiple lung metastases were treated with cisplatin, etoposide and bleomycin, without improvement. Treatment with mitotane (Lysodren) was also without effect and had to be discontinued because of severe side effects. Treatment with suramin (Germanin) was begun in August 1987. After a loading dose of 10.7 g for six weeks the lung metastases regressed almost completely. But lung metastases were again demonstrated in January 1988 during a low-dose maintenance regimen of suramin. Increased dosage arrested further growth, but achieved no regression of the metastases. The patient died unexpectedly in April 1988 of acute circulatory failure. Suramin administration had been discontinued six weeks earlier because of bronchopneumonia and general deterioration. Thrombocytopenia, coagulation disorders and moderate proteinuria were the side effects of suramin treatment.

Adrenal Cortex Neoplasms↗
PubMed1976

[Blood flow through different tissues under clonidine in rabbits (author's transl)].

The effect of i.v. administered clonidine on the blood flow through different tissues was investigated in six rabbits which had been anaesthetized with NembutalR. Six additional animals served as controls and received an equal quantity of a physiological sodium chloride solution. The blood flow was determined by means of radioactively labelled microspheres just before as well as 15, 30 and 45 min after the administration of the drug or the placebo respectively. In most of the investigated tissues a considerable decrease in blood flow was observed 15 min after the injection of clonidine, whereas no effect was to be seen after administration of sodium chloride. For the first time after 30 min, and even more after 45 min the blood flow diminished as well in the control group. The flow-decreasing effect of clonidine occured in lung, skin, choroid, the small intestine, the triceps muscle, the ciliary body, iris, and white matter, whereas the opposite reaction was observed in liver (hepatic artery), retina and the optic nerve.

Animals↗
PubMed1976

[The accuracy of ophthalmodynamometry in the diagnosis of occlusions of the carotid artery (author's transl)].

The aim of this study was to evaluate the diagnostic accuracy of ophthalmodynamometry in cases of occlusion of the internal carotid artery. Among the 29 patients examined with ODM there were 12 cases of such an occlusion, which were unknown to the ophthalmological examiner. All of them could be diagnosed exactly. When by means of ODM an occlusion in the region of the common or internal carotid was excluded the result was equally accurate. A decrease in ophthalmic blood pressure by 15% or a side difference of the same degree indicated in 80% of the cases an occlusion of the internal carotid. The ODM seems, therefore, to be a suitable test for finding or excluding such an occlusion.

Adult↗
PubMed1976

[Cataract during intermittent hemodialysis. The influence of hypocalcemia on the development of opacities (author's transl)].

Twenty uremic patients on intermittent hemodialysis were followed up for lens changes over 4-53 months. Only one patient of 22 years with megaureters and megacystis developed bilateral anterior and posterior subcapsular cataracts during dialysis treatment. The morphology of these cataracts was similar to that of fresh hypocalcemic opacities. The patient had actually been hypocalcemic before the onset of the opacification. Possible reasons for the development of hypocalcemic cataracts during intermittent dialysis might be: 1. a reduced calcium-phosphate ratio due to phosphate accumulation, 2. a decrease of ionized calcium due to removed metabolic acidosis, and 3. a permissive effect of longer latencies.

Adult↗
PubMed1975

Stagnation thrombosis: an iris fluorescein angiography study.

Two cases of central retinal venous thrombosis with gross involvement of the arterial supply to the retina are described. The iris fluorescein angiography showed massive leakage of dye into the anterior chamber. The iris angiographic findings in 48 cases of central venous thrombosis are compared with those of 19 patients with central retinal artery occlusion. In venous obstruction pupillary and extrapupillary vessels leak both in recent and in long-standing cases, whereas in arterial occlusions extrapupillary leakage occurs exclusively in recent cases. Comparatively, the 2 cases of stagnation thrombosis appear to show an exaggerated arterial type of response, and seem to form a distinct clinical entity as opposed to the basically venous insufficiency of central retinal vein thrombosis of the usual type.

Aged↗