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U Mittwoch

Publications and source records attributed to U Mittwoch.

At least 73 records · Page 4Linked to original sources
PubMed1975

Changes in the mitotic cycle induced by alpha-solanine.

Low concentrations of alpha-solanine stimulated the growth of cultured human fibroblasts, while higher concentrations (greater 30 mug ml-1) had a markedly inhibitory effect. Autoradiographic studies indicated that the stimulation of cell growth was due to a shortening of the G1 phase. Feulgen microdensitometry of cells treated with high doses of alpha-solanine revealed an abnormal accumulation of cells in G2. The response of cultured human fibroblasts to low doses of alpha-solanine is comparable to that of sex hormones on target tissues. It is concluded that by virtue of either its stimulatory or its inhibitory effect on cell growth, alpha-solanine could act as a human teratogen.

Autoradiography↗