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Biomedical subjects

U Patil

Publications and source records attributed to U Patil.

At least 19 recordsLinked to original sources
PubMed2000

Preliminary observations on lymphocyte subpopulations in HIV seropositive & HIV seronegative tuberculosis patients in Pune, India.

CD4 and CD8 lymphocyte counts were determined in 59 HIV seropositive and 41 HIV seronegative newly diagnosed tuberculosis patients in Pune. There were significant differences in the CD4 counts and CD4/CD8 ratios between HIV seropositive and HIV seronegative tuberculosis patients. Majority of the HIV seropositive patients had a CD4 count less than 500 cells/cu.mm, whereas among the HIV seronegative patients, majority had a CD4 count more than 500 cells/cu.mm. In HIV seropositive patients with extrapulmonary and pulmonary tuberculosis, the CD4 counts were lower than in those who had only pulmonary or extrapulmonary tuberculosis. There was no significant differences in the CD8 counts between HIV seropositive and HIV seronegative tuberculosis patients, except for patients with pulmonary cavity, where the CD8 counts were significantly higher in HIV seropositive tuberculosis patients. In HIV seropositive individuals with pulmonary tuberculosis, the CD8 counts in those with pulmonary cavity were higher than in those without any pulmonary cavity. Absence of cavitation and presence of pulmonary with extrapulmonary tuberculosis occurred when immune activation was at a lower level.

Adult↗
PubMed1999

Isolation & preliminary characterization of two HIV-2 strains from Pune, India.

Two HIV-2 strains were isolated from peripheral blood mononuclear cells of two HIV-2 seropositive patients with pulmonary tuberculosis by co-cultivating the cells with phytohaemagglutinin-P stimulated heterologous normal lymphocytes. Biological characterization of the isolates indicated that both isolates were syncytium inducing and induced cytopathic effect in the form of giant cells and syncytia formation in four T lymphoid cell lines. The isolates differed in their replication pattern. The isolates were confirmed as HIV-2 by nested PCR using HIV-1 and HIV-2 specific oligonucleotide primers from the env region and by supplementary tests like indirect immunofluorescence assay, syncytium inhibition assay using reference and HIV-2 reactive patients' sera, western blot and electron microscopy. Neutralization of one isolate (TB1) with two Senegal reference sera also indicated that the isolate may be related to the Senegal strain. To our knowledge, this is the first report of isolation of HIV-2 in India.

Adult↗
PubMed1997

Increasing trend of HIV seroprevalence among pulmonary tuberculosis patients in Pune, India.

A total of 4618 tuberculosis patients attending the TB clinic at the Sassoon General Hospitals, Pune between 1991 and 1996 were screened for anti-HIV antibodies. Of these 694 were found reactive in enzyme immuno assay (EIA) and 624 were further confirmed by a second test, either rapid EIA or Western blot. HIV-1 reactivity was predominant among tuberculosis patients with HIV-2 reactivity appearing only in 1995. HIV-2 seroreactivity accounted for 0.54 and 1.02 per cent of all HIV reactive samples in 1995 and 1996. HIV-1 and HIV-2 dual reactivity accounted for 1.63 and 2.04 per cent of all infections in 1995 and 1996. The overall seroprevalence of HIV among newly diagnosed tuberculosis patients rose from 3.2 per cent in 1991 to 20.1 per cent in 1996.

HIV Seroprevalence↗
PubMed1995

Modification of Dornier HM-4 lithotriptor for pediatric extracorporeal shockwave lithotripsy.

Extracorporeal shockwave lithotripsy has enjoyed increasing acceptance and utility in pediatric urology. The Dornier HM-4 lithotriptor has had good results in adults, but the gantry design does not allow smaller children to be treated. We have employed a specially designed yet simple 'spacer' to allow smaller children to be treated safely. The device may also have application in other patients with deformities who could not be treated in the past.

Child, Preschool↗
PubMed1995

Minimal surgery with renal preservation in anomalous complete duplicated systems: is it feasible?

From 1985 to 1993, 33 female and 4 male patients 0 to 3 years old presented with abnormal complete duplex systems of whom 25 had a prenatal diagnosis of hydronephrosis. Diagnosis in 40 ureteral moieties included ureteroceles in 10, ectopic ureteral insertions with reflux and obstruction in 17, and refluxing lower ureters in 13. Of 40 renal units only 6 (15%) required upper pole moiety ablation for pyelonephritis or nonfunction. None of the ablated renal tissue showed evidence of dysplasia. With the advent of prenatal diagnosis and minimal surgical intervention complete duplex anomalous urinary systems can be salvaged with preservation of altered renal units.

Female↗
PubMed1992

The role of tissue expanders in vaginoplasty for congenital malformations of the vagina.

There are many techniques of vaginoplasty in congenital malformations of the vagina, all of which involve the use of labial and perineal skin flaps. The results are not uniformly satisfactory because of delayed stenosis in many patients. To avoid this complication, we have used labial expansion with tissue expanders to obtain an elastic and sufficiently large skin flap. We recommend this technique in patients with the adrenogenital syndrome associated with varying degrees of virilisation and in other intersex anomalies.

Adolescent↗
PubMed1990

Calcified hypernephroma. A case report.

Pattern of classification in an renal neoplasm is variable. If calcium is located nonperipherally (within the mass) it is more likely to be a renal cell carcinoma. But peripheral calcification does not rule out malignancy.

Adult↗
PubMed1989

Urologist's perspectives of single-stage hypospadias repair in the 1980s. Experience of 100 patients.

During the last two decades major advances have been made in techniques of hypospadias repair. Many areas warrant meticulous attention to achieve further satisfactory results. We present areas of technique that have improved our results in genital reconstruction and hypospadias repair in particular. In addition to surgical technique modifications, we present technical refinements of patient positioning, use of cold antibiotic mixed saline, subcutaneous epinephrine at judicious sites, and microsurgical instruments as well as optical magnification and suture material. In genital anomalies, use of plastic surgical techniques with skin grafts and knowledge of the intrinsic vascular supply of the foreskin have further improved the outcome. Since 1982, 100 patients have been followed. Immediate complications total less than 1 percent; late complications total 10 percent including 9 percent fistula rate and 5 percent stenosis rate (urethral or meatal). No loss of skin flap or of neourethra were recorded.

Child↗
PubMed1986

Insidious erosion of a digit by a ring.

Avulsion injuries in fingers can be caused by rings worn on fingers. If the ring is tight, it can also cause an unusual problem, that of deep erosion into the finger. Only two cases with such erosion, both of them in adults have been reported so far. A child with a similar problem is presented here as a case report.

Child↗
PubMed1982

Genitourinary tract injuries due to fracture of the pelvis in females: sequelae and their management.

The pathophysiology of injury to the female genitourinary tract secondary to a fractured pelvis has been studied in 5 patients. Delayed complications were frequent and their management is described. It is concluded that a transpubic approach to the lower urinary tract facilitates the satisfactory reconstruction of the urinary tract. Long-term follow-up of 4 to 5 years is necessary for the satisfactory management of these patients following their initial injury.

Adolescent↗
PubMed1980

The surgical repair of membranous urethral strictures: experience with 105 consecutive cases.

We reviewed 105 patients with rupture of the membranous urethra in whom impassable strictures developed. With 16 years being the division between children and adults there were 73 adults and 32 children. We prefer to repair these strictures with the mobilized anterior urethra if this can be accomplished satisfactorily, rather, than using skin substitution urethroplasties. The mobilized anterior urethra was used in 90 patients: 63 adults and 27 children. The anterior urethra in the remaining 15 patients had been damaged either by a previous operation or by previous disease and needed skin substitution urethroplasty. Techniques, complications and results in the 3 types of repair are presented.

Adolescent↗
PubMed1980

Management of 18 difficult vesicovaginal and urethrovaginal fistulas with modified Ingelman-Sundberg and Martius operations.

Our experience in the management of difficult vesicovaginal and urethrovaginal fistulas is presented. The fistulas were secondary to radiation damage and extensive local fibrosis owing to previous attempts to repair surgically. Satisfactory surgical repair of the fistulas was obtained by interposition of viable gracilis muscle and labial fibrofatty tissue at the repair site. The patients have been followed for 1 to 2 years postoperatively.

Female↗
PubMed1977

Computed tomography of gas-filled bladder: method of staging bladder neoplasms.

Current methods of staging bladder carcinoma have many disadvantages. A new method of staging bladder tumors employing computed tomography (CT) of the gas-filled bladder is presented. Representative cases are demonstrated. Direct visualization of the extent of the tumor and adjacent soft tissue structures is possible. CT scanning of the gas-filled bladder is a promising new method for staging bladder tumors and following their response to therapy.

Aged↗