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Biomedical subjects

U Pazzaglia

Publications and source records attributed to U Pazzaglia.

11 recordsLinked to original sources
PubMed1987

Influence of atrophy on the efficiency of muscle reinnervation.

The effectiveness of motor reinnervation carried out after an interval of 20 days between nerve transection and reimplantation onto a foreign muscle was studied in the rat. Sixty days after reimplantation the compound action potential, the maximal indirect twitch and tetanic tensions, and weight loss were evaluated. The functional data demonstrated an incomplete recovery which differed from the complete functional restoration observed in an acutely denervated muscle reinnervated with a chronically severed nerve. Time-dependent changes induced in the muscle by denervation seem therefore to influence the efficacy of motor reinnervation.

Action Potentials↗
PubMed1985

Role of the interval between axotomy and nerve suture on the success of muscle reinnervation: an experimental study in the rabbit.

The influence of the time interval between nerve transection and neurorrhaphy on motor and sensory reinnervation was studied experimentally in the rabbit. We evaluated the maximal tetanic tension, the amplitude of the compound action potential, and the retrograde transport of horseradish peroxidase 30 and 60 days after neurorrhaphy carried out at 0, 10, or 20 days after transection of the nerves to the medial and lateral gastrocnemius and soleus muscles. The results showed that the suture 20 days after transection was followed by a more precocious motor reinnervation, whereas the outgrowth of motor axons past the suture was not affected by the time interval between transection and neurorrhaphy. On the contrary, the best regrowth of afferent axons was obtained after an interval of 10 days between transection and suture. We conclude that the time interval did not influence motor axon growth, but was involved in the operation of mechanism(s) involved in the reestablishment of impulse conduction and/or synaptic efficacy. In contrast, the time interval appeared to be related to factors involved directly in the axonal elongation of afferent fibers.

Action Potentials↗
PubMed1985

Neural nature of the time-dependent factor(s) involved in motor reinnervation.

The influence of a time interval between nerve transection and reimplantation into a foreign muscle on the effectiveness of reinnervation was studied in the rat. We evaluated the weight loss and the maximal twitch and tetanic tensions developed by the reinnervated muscle upon nerve stimulation 60 days after reimplantation (i) of an acutely severed nerve onto an acutely denervated muscle; (ii) of a chronically (20 days) severed nerve onto an acutely denervated muscle, and (iii) of an acutely severed nerve onto a chronically denervated muscle. The best recovery was obtained when a chronically severed nerve was implanted into an acutely denervated muscle. We conclude that a neural time-dependent factor(s) is involved in motor reinnervation.

Animals↗
PubMed1983

Reaction to methylmethacrylate in bone metastases treated by surgical curetting and filling with acrylic cement. Histological study of a case.

A femur bone metastasis from breast carcinoma was treated by curetting and filling with acrylic cement and osteosynthesis. The histological study of the resected proximal third of the femur five months after surgery shows a thin layer of connective tissue between bone and cement. There are no neoplastic cells in this connective tissue nor in the spongious bone of the proximal femur. Instead the diaphyseal channel is fully invaded with neoplastic cells. Pathogenesis and validity of surgical treatment by the emptying and filling with acrylic cement of bone metastases are discussed.

Aged↗
PubMed1983

Synchronous multicentric osteosarcoma.

A case of synchronous multicentric osteosarcoma is reported in an 11-year-old boy. This very rare condition is characterized by simultaneous involvement of multiple skeletal sites, and the prognosis is generally poor.

Bone Neoplasms↗