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Biomedical subjects

U R Shettigar

Publications and source records attributed to U R Shettigar.

At least 37 records · Page 2Linked to original sources
PubMed1982

Continuous enrichment of albumin in relation to globulins in plasma.

This in vitro study deals with the problem of continuous separation of albumin from globulins in patient's plasma and reinfusion of the useful components of the plasma to the patient as the substitution fluid during a plasma exchange (PE) treatment. A cascade filtration system is developed to generate continuously two plasma fractions, one rich in globulins and the other rich in albumins, using two filters (H1P100 filter with a molecular weight cutoff 100,000 and Diafilter 20 with a molecular weight cutoff 30,000). For example, the system is able to increase the albumin/globulin ratio of plasma from 0.42 to 1.98, and the albumin concentration in the secondary plasma fraction is about seven times higher than that in the primary plasma fraction. This system is expected to be clinically useful in eliminating the side effects inherent in the usage of any other substitution fluid during a PE treatment.

Blood↗
PubMed1977

Acute myocardial infarction and ischemic injury during surgery for coronary artery disease.

The incidence of myocardial infarction, acute ischemic injury, and associated serum enzyme abnormalities has been evaluated in four operations involving the coronary circulation. The highest incidence of infarction was associated with internal mammary implantation (Vineberg procedure). There was no significant difference in the incidence of infarction, ischemic injury, or abnormal enzyme levels between patients with stable angina and those with unstable angina who had vein bypass surgery. In operations involving combined vein bypass grafting and valve replacement surgery, the incidence of abnormal serum enzyme elevations was higher than in any other procedure. The incidence of infarction and acute ischemic injury in combined operations was similar to that in other procedures but this may have been due to the difficulty in the ECG diagnosis of infarction in this group of patients, most of whom had abnormal preoperative ECGs.

Acute Disease↗
PubMed1976

Left anterior descending coronary artery obstruction. Clinical, electrocardiographic, and angiographic correlates.

Seventy-six patients with severe (greater than 80%) occlusive left anterior descending coronary artery disease by coronary angiography were examined for the electrocardiographic characteristics of this disease in the presence (group A 59 patients) or the absence (group B 17 patients) of anterior wall asynergy (akinesis or dyskinesis). The incidence of clinically documented anterior myocardial infarction in these two groups of patients was examined. The collateral circulation to the left anterior descending coronary artery was also examined in the groups of patients with and without anterior wall asynergy. Thirty-eight of 59 (64%) patients with anterior wall asynergy (group A) showed electrocardiographic signs of anterior myocardial infarction, 17 per cent showed probable electrocardiographic signs of anterior myocardial infarction and 19 per cent showed no electrocardiographic signs. None of the 17 patients without anterior wall asynergy (group B) showed electrocardiographic signs of anterior myocardial infarction. In group A 74.6 per cent had documented clinical evidence of previous anterior myocardial infarction. Collateral filling of the distal left anterior descending coronary artery was seen in 71 per cent of group A and 100 per cent of group B patients. There was a significantly higher incidence (P = 0.02) of collateral filling in the patients without electrocardiographic evidence of definite anterior myocardial infarction (93% of 28 patients), than in those who showed definite electrocardiographic evidence of anterior myocardial infarction (66% of 38 patients).it is concluded that severe occlusive left anterior descending coronary artery disease with anterior wall myocardial asynergy is usually associated with electrocardiographic signs of anterior myocardial infarction, whereas equally severe left anterior descending coronary artery disease without anterior wall asynergy is rarely associated with electrocardiographic abnormalities of anterior myocardial infarction. Severe left anterior descending coronary artery obstruction without electrocardiographic and angiographic evidence of anterior myocardial infarction is usually associated with collateral circulation to the left anterior descending coronary artery and collateral circulation to the left anterior descending coronary artery is present less frequently when obstruction is associated with anterior myocardial infarction.

Adult↗
PubMed1975

Occult atrial septal defect in adults.

Two patients are described who presented with congestive heart failure and were found to have an atrial septal defect with a pulmonary blood flow approximately twice the systemic blood flow. Most of the usual clinical signs of atrial septal defect were absent, and the diagnosis was established by right heart catheterization and radioisotopic angiography. Both patients had hypertension and coronary artery disease. Atrial septal defect in the adult patient may not be recognized because of associated cardiac disease, including coronary artery disease and hypertension, or pulmonary disease which may obscure the usual clinical signs of a septal defect. Radioisotopic angiography and right heart catheterization should be considered in any patients with heart disease or congestive failure of obscure cause even if the usual diagnostic signs of atrial septal defect are absent.

Cardiac Catheterization↗
PubMedDate not supplied

Residence time distributions in artificial ventricles.

The time that blood elements remain in an artificial ventricle determines the period during which these blood elements are exposed to damaging factors. We present, for the first time, preliminary studies on the residence time distribution (RTD) of a ventricle as a function of type and orientation of valves (Bjork-Shiley and polyurethane valves). We constructed an open loop mock circulation system which simulates the flow and pressure through the left ventricle, and a drive triggered injection unit which can inject a chemical tracer or radioisotope during one diastolic filling phase. RTD studies were done using a Tc-99m radionuclide tracer and a chemical tracer. A scintillation camera clearly showed the influence of backflow through the artificial heart valves, and the intraventricular washout. Results indicate that 42% of the fluid elements are expelled at the end of the first ventricular beat, i.e., 58% of blood elements stayed behind to experience the second beat; 36% of blood elements expelled in the second beat belonged to those in the first diastole; 17% in the third beat; and 5% in a subsequent number of beats. The RTD was found to vary with the position of the Bjork-Shiley (BS) valves.

Blood Flow Velocity↗