Biomedical subjects
Publications and source records attributed to U Sabherwal.
A total of 274 samples were collected--180 sputum samples, 82 bronchial secretions and 12 pleural aspirates. Main fungus was Candida albicans from sputum (45.5 percent), from bronchial secretions (14.6 percent). Rest were Aspergillus, Alternaria and Helminthosporium. All the pleural aspirates were negative for fungus.
Study was carried out in 100 patients of non-specific vaginitis (NSV) to find out the incidence of vaginitis due to G. vaginalis. Out of a total of 100 subjects 20 were positive for G. vaginalis as compared to only 6 in equal number of normal matched controls. One positive specimen showed concomitant presence of C. albicans and E. coli was found in another positive specimen. Presence of amines and clue cells in the discharge did not correlate with the isolation rate of G. vaginalis, thus emphasizing the necessity of culture to diagnose NSV due to G. vaginalis.
Of a total of 730 strains of S. typhi isolated in 1989-90, in the Medical College Hospital, Rohtak (India), 218 isolates showed resistance to chloramphenicol, ampicillin and cotrimoxazole. Minimum inhibitory concentration (MIC) for ampicillin and cotrimoxazole was up to 3200 micrograms/ml, intermediate for chloramphenicol (200-800 micrograms/ml) and low for tetracycline (50-400 micrograms/ml). A significant observation was prevalence of E1 as the predominant phage type amongst resistant strains accounting for 88.8 per cent of the resistant isolates, 95.8 per cent of these showed block resistance to ACCoT.
It has been observed in the present investigation that ischemic myocardium consistently produces bright green fluorescence after Acridine Orange (AO) staining. The area of ischemia in the left ventricular myocardium at different time intervals after onset of experimental ischemia has been calculated by use of this AO fluorescence technique. Zonal distribution of ischemia in the epicardial, middle, and endocardial zones has also been evaluated quantitatively from ten minutes to six hours after ligation of the anterior descending branch of the left coronary artery in the Wistar strain of albino rats. No similar study was available for comparison from the literature reviewed. The total area of left ventricular ischemia showed an increase with the prolongation of duration of coronary ligation from 13.39 +/- 2.69 mm2 at ten to twenty-five minutes to 32.99 +/- 5.69 mm2 at six hours after ligation. Statistical analysis of the zonal area of ischemia has shown that ischemia in the middle and endocardial zones was greater than that in the epicardial zone at all time intervals recorded. Middle zone ischemia extended over a larger area than that over the endocardial zone at all intervals except at intervals II (30-45 min), IV (2-2 1/2 hrs) and V (3-4 hrs). The results of this experimental investigation are significant for these point to the value of Acridine Orange fluorescence in detecting early myocardial ischemia and in demarcating zonal differences in ischemia. The authors have successfully utilized the method in a few human cases of clinically suspected myocardial infarction and recommend the technique for routine use to detect early human myocardial ischemia.
Estimation of T and B lymphocytes was done in 50 patients of enteric fever, 50 duration matched non enteric fever patients and 50 normal healthy individuals. The difference in both early and late rosette forming T lymphocytes was found to be statistically significant in enteric versus non-enteric patients. Significant difference was also observed in enteric versus normal individuals in case of late rosette forming T lymphocytes.
Necropsy findings in 3 cases of conjoined thoracopagus twins are presented. Conjoined hearts were seen lying in a common pericardial cavity. In 2 cases the common atrial complex was incompletely divided into the atrial cavities of the twins by ridges arising from the floor of the cavity. In 1 case the atrial division was better defined and the interatrial septal defect of septum secumdum type was seen. Pulmonary veins opened normally into the atrial chamber only in 1 case, in the other 2 cases, these veins opened into the inferior vena cava and the liver respectively. Ventricular chambers were common in 2 cases with 3 rudimentary atrioventricular openings guarding the inlet and multiple VSD of muscular type. In 1 case one twin had 2 completely separated ventricular cavities and the other twin had partially separated ventricular cavities with a muscular VSD. Great vessels showed transposition in all the cases. In 1 case d-transposition of a rare variety was seen which was associated with a subaortic as well as subpulmonic conus. Persistent ductus arteriosus was a cmmon feature and valvular type of pulmonic stenosis was seen in 2 cases.
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