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U Saueressig

Publications and source records attributed to U Saueressig.

6 recordsLinked to original sources

Artifact reduction in moving-table acquisitions using parallel imaging and multiple averages.

Two-dimensional (2D) axial continuously-moving-table imaging has to deal with artifacts due to gradient nonlinearity and breathing motion, and has to provide the highest scan efficiency. Parallel imaging techniques (e.g., generalized autocalibrating partially parallel acquisition GRAPPA)) are used to reduce such artifacts and avoid ghosting artifacts. The latter occur in T(2)-weighted multi-spin-echo (SE) acquisitions that omit an additional excitation prior to imaging scans for presaturation purposes. Multiple images are reconstructed from subdivisions of a fully sampled k-space data set, each of which is acquired in a single SE train. These images are then averaged. GRAPPA coil weights are estimated without additional measurements. Compared to conventional image reconstruction, inconsistencies between different subsets of k-space induce less artifacts when each k-space part is reconstructed separately and the multiple images are averaged afterwards. These inconsistencies may lead to inaccurate GRAPPA coil weights using the proposed intrinsic GRAPPA calibration. It is shown that aliasing artifacts in single images are canceled out after averaging. Phantom and in vivo studies demonstrate the benefit of the proposed reconstruction scheme for free-breathing axial continuously-moving-table imaging using fast multi-SE sequences.

Artifacts↗

Using receiver operating characteristic methodology to evaluate the diagnostic quality of radiography on paper prints versus film.

OBJECTIVE: The aim of this study was to compare the diagnostic quality of paper prints with film copies in a sample of observers who were trying to detect small coin lesions on radiographs of a phantom. MATERIALS AND METHODS: The phantom consisted of 60 high-contrast and 60 low-contrast test objects, half of which had holes in them. Diameter and depth of the holes varied from 0.5 mm to 2 mm. Fifteen radiographs were obtained from different areas of the test objects. Film copies and paper prints were made using high-quality printers. Five observers independently evaluated 1,800 high-contrast and 1,800 low-contrast images. Data were evaluated using the well-established receiver operating characteristic methodology. RESULTS: The mean area under the curve rated 0.863 for paper prints (0.859 for high contrast and 0.860 for low contrast) and 0.926 for laser films (0.937 for high contrast and 0.913 for low contrast). The difference between the two imaging techniques was statistically significant for both high- and low-contrast lesions (p < 0.05). CONCLUSION: Detection of small coin lesions on radiographs of a phantom was significantly less sensitive on paper prints than on film. We found paper prints less acceptable for the diagnosis of small-sized lesions.

Diagnostic Errors↗

[Image quality of paper prints compared to film copies in CT investigations].

PURPOSE: Evaluation of image quality of paper prints in routine CT investigations. METHOD: The image quality of paper prints from 104 CT scans of daily routine investigations was analysed by three observer three observers according to a five-point ranking scale for contrast, grey level, spatial resolution, and subjective confidence in correct evaluation. Each study was rated "acceptable" or "not acceptable for documentation". RESULTS: In 312 ratings the mean grade for contrast was 2.7, for grey levels 3.2, and for spatial resolution 3.3. Grades ranged from 1 = very good to 5 = insufficient. Subjective confidence in correct evaluation was rated as "certain" in 77.4 %, "likely" in 18.4 % and "impossible to evaluate" in 4.2 % of cases. 93.7 % of printed CT images were rated "acceptable for documentation". CONCLUSION: Image quality of paper prints does not reach the quality of laser films concerning its contrast, grey levels, and spatial resolution. Nevertheless, paper prints are acceptable for documentation of findings in most CT investigations. A high confidence in correct evaluation was found. Limitations are found in documentation of small coin lesions of the lung and ischemic lesions of the neurocranium.

Humans↗

Extracellular nucleotides regulate cellular functions of podocytes in culture.

Extracellular nucleotides are assumed to be important regulators of glomerular functions. This study characterizes purinergic receptors in podocytes. The effects of purinergic agonists on electrophysiological properties and the intracellular free Ca(2+) concentration of differentiated podocytes were examined with the patch-clamp and fura 2 fluorescence techniques. mRNA expression of purinergic receptors was investigated by RT-PCR. Purinergic agonists depolarized podocytes. Purinergic agonists similarly increased intracellular free Ca(2+) concentration of podocytes. The rank order of potency of various nucleotides on membrane voltage and free cytosolic calcium concentration was UTP approximately UDP > [adenosine 5'-O-(3-thiotriphosphate) (ATP-gamma-S)] > ATP > 2-methylthioadenosine 5'-triphosphate (2-MeS-ATP) > 2'- and 3'-O-(4-benzoylbenzoyl)-adenosine 5'-triphosphate (BzATP) > ADP-beta-S. alpha,beta-Me-ATP was without effect. In the presence of UTP, BzATP did not cause an additional depolarization of podocytes. Incubation of cells with ATP or BzATP did not induce lactate dehydrogenase release. In RT-PCR studies, mRNAs of the P2Y(1), P2Y(2), P2Y(6), and P2X(7) receptors were detected within glomeruli and podocytes. The data indicate that extracellular nucleotides modulate podocyte function mainly by an activation of both P2Y(2) and P2Y(6) receptors.

Adenosine Triphosphate↗

Diagnostic accuracy of MRI for preoperative staging of pancreatic carcinoma: tendency for understaging.

OBJECTIVE: To evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) for preoperative staging in pancreatic carcinoma. MATERIALS AND METHODS: MRI investigations, including MR-angio and MR-cholangiopancreatography (MRCP) of 19 patients who underwent surgery for pancreatic carcinoma were retrospectively evaluated by two radiologists. The size, localization of the tumor and possible infiltration of neighboring organs, as well as the presence of enlarged lymph nodes, were determined to define a preoperative, radiological TN stage. Lymph node metastasis was defined as peripancreatic lymphoma greater than 10 mm. Our findings were correlated to postoperative diagnosis. RESULTS: The T-stage was correctly evaluated in 52.6% of the cases (10/19). Understaging took place in 31.6% (6/19) and overstaging in 15.8% (3/19). In three cases of understaging, a micro-infiltration of the peripancreatic tissue was not visible in MRI. Pathologically enlarged lymph nodes were correctly found in 63.2% of the cases (12/19). Overstaging took place in 21.1% of the cases (4/19) and understaging in 15.8% (3/19). CONCLUSION: MRl for preoperative staging of pancreatic carcinoma showed a tendency to understage tumor size in this study population. Especially in cases of small tumor size, micro-infiltration of peripancreatic tissue or the common bile duct may not be detected by MRI. Concerning N-stage, the 95% confidence interval reveals a distribution of over- and understaged.

Aged↗