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Biomedical subjects

U Schwiersch

Publications and source records attributed to U Schwiersch.

4 recordsLinked to original sources
PubMed1988

Pharmacokinetics of sulbactam and ampicillin intravenously applied in combination to healthy volunteers and patients. Determination of the ratio of the two drugs in serum and in various tissues.

The pharmacokinetics of sulbactam, a new beta-lactamase inhibitor, and ampicillin were investigated in 9 healthy volunteers and 125 patients. The two drugs were administered intravenously in combination (Unacid). Each subject received 1 g sulbactam and 2 g ampicillin. The two drugs showed a similar pharmacokinetic profile in humans. Relevant pharmacokinetic parameters were calculated using a 2-compartment model on the basis of the serum and urine concentrations determined in healthy volunteers. The ratio of sulbactam to ampicillin was found to be nearly constant (approx. 1:2), both in the blood, in several tissues and at various time points. The two compounds apparently penetrated well into the myometrium, renal cortex and medulla, the gall bladder wall, the tonsils and the cutis of the skin. The sulbactam/ampicillin ratios in the bile ranged from 1:3 to 1:13 over 2 h after the infusion. The concentrations of the two compounds measured in the various fluids and tissues of the body reached levels which are effective against beta-lactamase producing bacteria. The similar pharmacokinetics of sulbactam and ampicillin in humans are considered an essential prerequisite for the therapeutic efficacy of such a combination product.

Adult↗
PubMed1986

[Urodynamic observations on the Marshall-Marchetti-Krantz operation].

Urodynamic tests and clinical and anamnestic assessments of continence were carried out in 47 patients before and after the Marshall-Marchetti-Krantz operation. The operation resulted in a subjective cure in 35 (74.5%) of the patients; 12 women were again incontinent within a period of between 6 and 24 months. There was an insignificant postoperative rise in urethral occlusion pressure at rest. It was only possible to ensure an elongation of the urethra in the resting pressure curve. The urethral occlusion pressure at rest in patients with recurrent incontinence was considerably lower preoperatively than in postoperatively continent patients. Hence, high urethral occlusion pressure at rest signifies a good surgical prognosis. In the stress pressure curve, surgery improved the transmission factor, the depression factor, and the urethral occlusion pressure under stress. However, no clear surgical prognosis was possible on the basis of these parameters. The best postoperative results for the transmission and depression factors and the urethral occlusion pressure under stress were obtained in the stress pressure curve at 300 ml with the patient in seated position. On comparing preoperative and postoperative measurements, improvements in pressure transmission and in urethral occlusion pressure under stress were seen in particular in the proximal one-third of the urethra. Hence, the question arises whether the proximal one-third of the urethra is as important as the medial one-third in stress incontinence diagnosis by measurement.

Female↗
PubMed1986

Concentration of sulbactam and ampicillin in serum and the myometrium.

Sulbactam 1g and ampicillin 2g were administered intravenously to 12 patients, and concentrations of the drugs were determined in the serum and myometrium for up to 120 minutes after infusion. The ratio of sulbactam to ampicillin was about 1:2 in the serum and myometrium. Both drugs penetrated well into the myometrium, and median concentrations of sulbactam and ampicillin were 65% and 68%, respectively, of those in the serum. Sulbactam/ampicillin was effective for perioperative prophylaxis and should be effective as therapy for pelvic infections.

Ampicillin↗