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Biomedical subjects

U Seppelt

Publications and source records attributed to U Seppelt.

11 recordsLinked to original sources
PubMed1986

Investigation of automated DNA diagnosis and grading of prostatic cancer.

As a preliminary step towards a DNA-related automatic diagnosis and grading, the fine needle aspiration biopsies of 85 patients with prostatic cancer and of 20 patients with benign prostatic hypertrophy were subjected to DNA single-cell fluorescence cytometry. The DNA histograms were analyzed statistically by univariate data description, stepwise linear discriminant analysis and multiple regression analysis. The accuracy of the DNA-based malignancy diagnosis was 85.1%, with 10.6% false-negative and 4.3% false-positive results. The accuracy of the prognosis-related malignancy grading was, however, only 39.5% and thus unsatisfactory. The results indicate that a DNA-related diagnosis of prostatic malignancy is possible but that a similar automatic grading of prostatic cancer is not yet possible.

Biopsy, Needle↗
PubMed1979

[Complications following ureteroneocystostomy without antireflux technique in the adult (author's transl)].

65 adult patients subjected to direct uretero-vesical implantation without the use of a recognized antirefluxing technique were followed up to 9 years. Good results could be achieved in 90.8%, whereas failures were mainly due to radiation damage and malignant tumors. A postoperative stenosis was observed five times. Reflux was demonstrable in 7 cases, of which, however, only one was of pathologic significance.

Aged↗
PubMed1978

Correlation among prostate stroma, plasma estrogen levels, and urinary estrogen excretion in patients with benign prostatic hypertrophy.

Plasma testosterone, plasma estradiol, and the total estrogen excretion in the urine were obtained from patients with benign prostatic hypertrophy and correlated to the histological pattern of the resected or enucleated prostates. There was a highly significant increase of prostate stroma in association with higher individual estradiol concentrations and urinary estrogen excretion, while no apparent correlation could be found with testosterone.

Aged↗
PubMed1978

[Videocystometry (VCM)--a method for quantitative and qualitative diagnosis of refluxes (author's transl)].

Videocystometry (VCM) is a combination of videography and cystometry for the investigation of vesico-ureteral refluxes and is an accurate method of reflux classification that registers intravesical pressure and volume simultaneously after X-ray detection. We investigated 86 refluxes detected by micturating cystourethrography; 21 could not be confirmed, 14 disappeared with conservative treatment, and 10 underwent surgery, because their condition became worse during examination. Especially refluxes without primary indications for operation can be verified by comparative data. This facilitates the decision to continue conservative or operative treatment.

Humans↗
PubMed1977

[Toxic dilatation of the colon].

Twelve patients (8 males and 4 females) with toxic dilatation of the colon in acute ulcerative colitis were reviewed, who required surgery between 1962 and 1974 at the Department of Surgery, University Kiel. This complication always occured during a relapsing exacerbation of known colitis. Nine patients died. This high operative mortality (75%) was related to faecel sepsis because of praeoperative perforations, operative disruptions of walled-off perforations and to a delaying conservative approach of more than ten days. These results with the onestage coloproctectomy or colectomy with later excision of the rectum urge an early surgical intervention before perforation took place. The diverting ileostomy and decompression colostomy may additionally lead to a better prognosis.

Adult↗
PubMed1976

[A second bladder-neck intervention following open transvesical prostatectomy (author's transl)].

Over a 10-year period 27 patients required a second transurethral revision operation after previous open transvesical prostatectomy. The so-called sphincter-sclerosis, residual and recidivous adenoma, and prostatic cancer were the causes of repeated bladder neck obstruction. Prostatic cancer after prostatectomy seems to be more benign clinically, more differentiated histologically and is diagnosed sooner because it presents with earlier symptoms than does primary prostatic cancer.

Adenocarcinoma↗
PubMed1975

[Pararenal pseudocyst. A rare sequela following blunt abdominal trauma (author's transl)].

On the basis of an organ preserving operative case, the patho-physiological postulation of the origin and the diagnostic difficulty of this rare clinical picture are discussed. Out of the only 30 cases known in the world literature, 26 nephrectomies had to be made. Decisive for the formation are the grave concomitant injuries which mask the local symptomatology of the ureter tear. The duration of the interval trauma - therapy influences decisively the chances of organ preservation (from many weeks to 37 years is unknown).

Abdominal Injuries↗