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Biomedical subjects

U Sitka

Publications and source records attributed to U Sitka.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Pharmacokinetic investigations on sisomicin in children (author's transl)].

Sisomicin is an aminoglycoside effective against gramnegative germs. The sensitiveness of coli, proteus, pseudomonas and klebsiella ranges from 0,1 to 0,4 mcg/ml. Germs with inhibition-values of up to 1 mcg/ml are certainly Sisomicin-sensitive. The side-effects of Sisomicin resemble those of other aminoglycosides, as for instance lesions of the VIIth cranial nerve and the kidney. Since aminoglycosides have a relatively small therapeutic range between toxicity and effective minimal-concentration, investigations are important especially in children. 66 children of different age groups received Sisomicin in doses of 3 mg/kg, 2 mg/kg and 1 mg/kg, and examined pharmacokineticly. Serum-levels were measured after 30 min 1, 2, and 4h, in some cases also after 6 and 8 h. In a separate group we determined the values after 5, 10, 15, 20, 30 and 40 min. The urinary output was controlled and the content of Sisomicin in meconium determined. Based on these results we recommend an individual, Sisomicin dosage for each age group. Clinically the Sisomicin proved to be well tolerated and effective antibioticum.

Age Factors↗
PubMed1977

Experience with amoxycillin in neonates and premature babies.

Amoxycillin, a semi-synthetic penicillin, resembles ampicillin in many respects. There is cross-resistance between the two antibiotics. Numerous Gram-positive and Gram-negative organisms are sensitive to amoxycillin at relatively low dosage. Investigations using oral amoxycillin, 50 mg/kg body weight were carried out in neonates and premature babies in the first days of life. Peak values of 38 microng/ml and 59 microng/ml at 4 1/4 hours were obtained for the neonates and premature babies respectively. The 10-hour value for the first group was 13 microng/ml and for the second 19 microng/ml. With a single dose of amoxycillin, serum levels of 0.9 microng/ml were still obtained after 24 hours. In children who received the same dose twice daily, the serum values were 6.5 microng/ml after 24 hours. The urinary excretion of amoxycillin was, on an average, 41% in 24 hours. Amoxycillin was also found in the meconoium, but the quantity in the different portions showed a large dispersion. Amoxycillin can, therefore, be recommended as an effective and well tolerated antibiotic for use in the neonatal and premature period. In general the drug should be administered 12-hourly at a dose of 50 mg/kg body weight. Only in severe illnesses is 8-hourly administration required.

Amoxicillin↗
PubMed1976

[Clotrimazol in the treatment of candida infections in premature and newborn children (author's transl)].

The early infancy is especially affected by moniliasis in pediatrics. The causes are: broad spread of Candida albicans in the environment of these children, a growing immunity, the immaturity of the skin and an insufficient candida-static activity of the serum. The prematures and the newborns with an irregular birth are especially endangered. This danger is increased by simultaneous antibiotic therapy. The arising mycosis can reach from the relative harmless mouth- and diaper-thrush to serious septic diseases. An effective therapy therefore is very much desired. As new efficacious medicaments the derivates of imidazol, Clotrimazol, have proved satisfactory for the treatment of mycoses. It is as Canesten marketed. The drug possesses a strong activity against numerous fungi, some protozoa, and bacteria. In this paper it is reported on own pharmacokinetic and therapeutic investigations with Clotrimazol. The substance has been very useful for the treatment of mouth- and diaper-thrush. Clotrimazol was administered as BAYb 5097 peroral and local as Canesten -solution 1% and -cream 1%. There were 171 treatments carried out. Essential side-effects were not observed.

Administration, Oral↗
PubMed1976

[Clinical and pharmacokinetic researches of doxycyclin vibravenös in childhood (author's transl)].

Doxycyclin is one of the first efficacious depot antibiotics. It is used in two applications as Vibramycin (R) (peroral and Vibravenös (R) (parenteral). Doxycyclin has a favourable effect not only on different gram-positive and gram-negative bacteria but also on a lot of other germs as mycoplasms, rickettsias, protozoons and large viruses. The tissue invasions is a good one, because there is only a low fraction of free Doxycyclin and further a high lipid activity. Pharmacokinetic investigations of different age-groups show that good serum-levels can be reached because of the sensitivity of numerous germs. The levels are higher, as our experiences demonstrate, if the dose of 4 mg/kilo/weight is injected in two single doses. Our investigations are reported on 49 patients with diseases of the respiratory tract and on 25 patients with diseases of the urogenital tract. Doxycyclin was very useful especially in different forms of pneumonias. The results in infects of the urogenital tract are not so good ones. The compatibility of Doxycyclin can be characterised as very good for children.

Adolescent↗
PubMed1975

[Intravenous administration of doxycycline vibravenös in childhood--clinical and pharmacokinetic problems].

The paper describes special advantages of doxycycline, especially also in comparison with other tetracyclines, the possbile side-effects of the preparation, and the various ways of application-under special consideration of the pathogenetic spectrum. Pharmacokinetic examination were carried out in eight permature babies, nine new-born, eight normal babies, and in two groups of school children, comprising 7 and 8 test persons each. During these examinations, the serum levels after 1, 6, 10, and 24 hours were evaluated. The values found showed levels in the range of bacteriologic efficiency as far as premature babies and new-born - after 24 hours and with 0.6 gamma/ml - were concerned. In older babies and school children, the values had decreased, after a single application, within 24 hours to 0.2 to 0.15 gamma/ml. However, it has been possible to achieve final values of about 1.5 gamma by applying the preparation twice, i. e. 2 x 2 mg/kg body-weight, within 24 hours. The complete course of elimination of Vibravenös was determined in 8 school children by blood sample taking after 5, 10, 15, and 20 minutes as well as after 1, 3, 6 hours. The values found herein were calculated by means of computer analyses. Half-life of doxycyclin in infantile individuals is subject to rather strong variations. Therefore, a higher dose than usual so far is recommended, viz 6 MG/KG B.W. as initial dose and 3 mg/kg b.w. as maintenance dose.

Age Factors↗