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U Stenevi

Publications and source records attributed to U Stenevi.

At least 37 records · Page 2Linked to original sources
PubMed1998

Endogenous hyaluronan in the normal and traumatized rabbit iris.

PURPOSE: Hyaluronan concentration in the iris tissue after iridectomy was studied in order to establish the influence of trauma on the production of hyaluronan in the anterior chamber of the eye and whether the iris participates in this process or not. METHOD: Hyaluronan was measured with a radiometric assay at different time points after surgery and identified with specific histochemical staining. RESULTS AND CONCLUSIONS: The concentration of hyaluronan in iris tissue peaked two days after surgery, reaching an average of 115.3 (S.E.M.:+/-12.2) microg/g. It then decreased slowly to almost normal values after 3 to 5 weeks. Histochemistry demonstrated the most intense hyaluronan staining in the iris stroma and in iridial processes around the iridectomy two days after the operation. Our findings indicate in situ synthesis of hyaluronan in the iris tissue.

Animals↗
PubMed1997

An outcome study of cataract surgery based on a national register.

PURPOSE: To test the viability of performing a national cataract outcome study with a national cataract register as a reference base. METHODS: Seven Swedish eye clinics participated. All patients operated during the month of January 1994 were included. The total number of patients was 605. RESULTS: This outcome study is based on few, but well defined parameters. On the basis of these measurements quality indicators are suggested that makes comparison between surgeons/clinics possible. CONCLUSION: Outcome studies are different from controlled clinical trials. They are less time consuming and designed to describe the outcome of surgery in daily practise. An outcome study of cataract surgery does not replace the careful monitoring of each patient at the clinical level, which is necessary for the development of new surgical technics and medical treatments. However, an outcome study can provide an overall quality description of cataract surgery in the daily practise of any given surgical unit.

Aged↗
PubMed1996

Cataract surgery in a Swedish population: observations and complications.

PURPOSE: To describe relevant clinical conditions at cataract surgery in a defined Swedish population, examine variables and their influence on the operative procedure, and estimate the risk of complications at surgery. SETTING: Department of Ophthalmology, Lund University Hospital, Sweden. METHODS: Using the Cataract Analysis System, data were prospectively collected on 5878 consecutive cataract surgeries performed in a single Swedish health care district from 1986 to 1990. Patients younger than 15 years were not included. The study population was complete enough to represent all cataract surgeries in the referral region of the Lund Health Care District during this period. The incidence of zonular or lens capsule rupture at surgery was used as a measure of surgical complications and assessed as a function of other preoperative and surgical parameters. A logistic regression model was used to assess the probability of complications at surgery. RESULTS: Glaucoma was the highest statistically significant preoperative risk factor for capsular or zonular rupture at surgery, with or without vitreous loss, with a relative risk of 2.7 (i.e., a 2.7-fold increase in risk over patients without glaucoma). Surgeons performing fewer than 40 operations in 5 years had a relative risk of zonular or capsular rupture of approximately 2.9 (i.e., a 2.9-fold increase in risk over high-volume surgeons). The overall risk was 2.5%. CONCLUSION: Cataract patients with glaucoma have an increased risk of complications at surgery. Surgeons performing few operations tended to have more capsular or zonular ruptures.

Cataract Extraction↗
PubMed1996

Assessment of waiting time and priority setting by means of a national register.

To increase access to care for cataract patients in Sweden, it was decided, starting in 1992, that all cataract patients listed for surgery and with priority should have their cataract extraction performed within three months. To evaluate the effect of this waiting time guarantee, a National Cataract Register (NCR) was initiated in late 1991. In 1992, 81% of all cataract extractions performed in Sweden were reported to the NCR; in 1993 this figure was 92%. Reasons for this high participation ratio are discussed. In 1993, 74.4% (range between different clinics, 40-99%) of the patients with priority had their operation performed within three months. Great variation in visual acuity and age was found in patients with priority among the different surgical units.

Cataract Extraction↗
PubMed1996

The results of penetrating keratoplasty for keratoconus.

At the Department of Ophthalmology, University Hospital in Lund, Sweden, keratoconus is the most common indication for penetrating keratoplasty. We studied 77 keratoplasties performed on keratoconic eyes between 1989-1991. Postoperative corrected visual acuity was better than or equal to 0.5 in 65 eyes (84.4%), and 30 eyes (39%) had visual acuity of 1.0. The mean postoperative astigmatism was 3.75 D with a range of 0-12.5 D. Eight patients underwent relaxing incision with satisfactory results in 6 patients. Graft rejection was observed in 6 eyes (7.8%). The most serious complication seen in our group of patients was a retrocorneal fibrous membrane that developed in one patient.

Adolescent↗
PubMed1996

Acanthamoeba keratitis in the south of Sweden.

Eight patients with Acanthamoeba keratitis were diagnosed and treated at our clinic between February 1991 and February 1993. Five of these were contact lens wearers, two had suffered recent corneal trauma and one had recently undergone penetrating keratoplasty. The diagnoses were based on both culture and histological examination of biopsy material in three cases, on culture alone in two cases and on histological examination alone in three cases. In all but one primary treatment was Propamidine isethionate and Neomycin/Polymyxin B topically and Ketoconazole orally. Because of poor healing three patients additionally received Paromomycin and Miconazole or Clotrimazol topically; two of these were further treated with Polyhexamethylene biguanide topically. The interval from initial symptoms to accurate diagnoses varied from one to eleven months. In one patient the eye could not be saved; in the remaining patients visual acuity after healing ranged from hand movements to 1.0.

Acanthamoeba↗
PubMed1995

A national Cataract Register. I. Description and epidemiology.

In 1992 a Swedish National Cataract Register was instituted. More than 90% of all cataract surgeries are performed at community run eye clinics. All community run eye clinics in the country participated and 89% of all cataracts performed are included in this register. In total 31,679 eyes were entered. All the pertinent preoperative information on these patients can be found in the register. As indicated in other studies two-thirds of the surgeries were performed on women and one-third of the surgeries was performed on second eyes. The number of surgeries equals 4.5 per 1000 inhabitants and this figure has steadily increased since 1980.

Adolescent↗
PubMed1995

Cataract patients in a defined Swedish population 1986-90: VII Inpatient and outpatient standardised mortality ratios.

AIMS: Cataract surgery has at times been said to correlate with an increased death risk. We have therefore analysed the standardised death ratio in a population based cohort of patients that had undergone cataract surgery. METHODS: Data for all patients undergoing cataract surgery from 1986 up to and including 1990 in the Lund Health Care District were prospectively recorded, and 5120 were retrieved for analysis. Death dates and primary death diagnoses for each patient were obtained from the Swedish Bureau of Census up to and including 1991. Standardised mortality ratios were calculated for all patients, subdivided into a number of categories: inpatients, outpatients, sex, age < 75 years, age > or = 75 years, patients with heart and circulatory diseases, with malignant tumours, and with diabetes. The cut off age was set at 74 because this divided the patients into two approximately equal groups. Using time dependent survival regression, the relative risk for dying were estimated for sex, age, and for postoperative YAG laser capsulotomy, and also for diabetic patients and patients with rheumatoid arthritis. RESULTS: Inpatients almost always show an increased standardised mortality ratio compared with outpatients. Young patients and diabetic patients also showed an increased standardised mortality ratio, compared with the normal population, but not older patients, who constitute the majority. Cardiovascular death diagnoses were overrepresented among the young. CONCLUSIONS: Cataract surgery is correlated with an increased standardised mortality ratio only in young patients and in patients with certain complicating diseases like diabetes and cardiovascular diseases.

Aged↗
PubMed1994

Cataract patients in a defined Swedish population 1986-1990. II. Preoperative observations.

With the Cataract Analysis System (CAS) we have analyzed 5.878 consecutive patients undergoing cataract operations from 1986 through 1990. The material is complete enough to be regarded as representative of the cataract surgery performed in the Lund Health Care District cataract surgery referral region during this period. There has been a striking increase in the number of operations, in 1990 reaching 3.6 per 1000 inhabitants in the referral region. A number of demographic factors have been analyzed previously, and the preoperative status of the patients is reported in this paper. In 1986, the cataract patients showed more visual impairment than in 1990, but the average age at surgery did not change between the years. We therefore suggest that the increase in the number of patients which were operated on represents a new category that was added. During the period, the planned refraction has changed towards emmetropia, presumably reflecting several kinds of improvements in the procedure. About 78 per cent of the population had a preoperative astigmatism < 1.5 D. As expected males had slightly longer eyes than women, and their corneal curvature was also slightly less.

Adolescent↗
PubMed1994

Cataract patients in a defined Swedish population 1986-1990. I. Resources and epidemiology.

With the Cataract Analysis System (CAS) we have analyzed 5878 consecutive cataract patients operated from 1986 through 1990. The material is complete enough to be regarded as representative of the cataract surgery performed in the entire referral region of the Lund Health Care District during this period. There has been a striking increase in the number of operations, in 1990 reaching 3.6 per 1000 inhabitants in the referral region. Simultaneously, surgery has changed from being mainly an in-patient to an out-patient procedure. Females predominate in the material, also after adjustment for the female preponderance in the population. Most likely, this is due to a higher incidence of cataract in women than in men.

Adolescent↗
PubMed1994

Endogenous hyaluronan in corneal disease.

PURPOSE: Hyaluronan (HA) is a disaccharide polymer capable of binding considerable amounts of water. It is present in trace amounts on the cornea endothelium, and it is not normally found in the epithelium or stroma. A specific histochemical stain was used to test for HA in a wide variety of corneal disorders. METHODS. Eighty-six human corneal tissue specimens were examined histochemically for HA. The material consisted of 84 full-thickness corneal buttons, one epithelium scraping, and one pterygium. Cases were analyzed according to the patient's sex, age, diagnosis, and localization of HA staining. RESULTS: The corneal tissue specimens came from 47 women and 39 men, average age 59 years. Fifty-seven percent of the specimens displayed abnormal HA. HA was visualized in Fuch's dystrophy, keratoconus, infections, regrafts, mechanical and chemical trauma, post-excimer ablations, dystrophies, degenerations, pseudophakic bullous keratopathy, congenital opacities, Stevens-Johnson syndrome, and others. Staining was variously seen in the epithelium, stroma, and endothelium, with intensity of staining ranging from trace amounts to extremely heavy. CONCLUSIONS: Endogenous hyaluronan production is seen in virtually the entire spectrum of corneal disorders. The presence of HA was most often associated with dividing, migrating, or fibroblast-like cells and probably represents a nonspecific tissue response to wounding. Its production is biochemically distinct from that of normally present proteoglycans. The abnormal presence of HA may reduce corneal transparency by disrupting the normal spacing between collagen fibrils, creating focal changes in the index of refraction, and altering the normal flow of solutes through the cornea.

Adolescent↗
PubMed1993

Histochemical identification of hyaluronan in the rabbit anterior segment during the healing period after extracapsular lens extraction.

Extracapsular lens extractions were performed in rabbits. The eyes were examined at different time intervals after surgery with a histochemical method visualizing hyaluronan. There was positive staining for hyaluronan in the wound region from 2 to 90 days postoperatively. The staining was most intense and widespread between 7 and 14 days after surgery. A hyaluronan staining in the corneal stroma extended from the wound towards the central cornea 4 to 14 days postoperatively. The iris showed increased staining on the second postoperative day, but much less so at the other times studied. Cells on the posterior lens capsule were surrounded by hyaluronan from the seventh postoperative day throughout the observation time up to 90 days postoperatively. It is concluded that hyaluronan reacts during corneal wound healing.

Animals↗
PubMed1992

Evidence of hyaluronic acid and hyaluronic acid binding sites on human corneal endothelium.

A highly specific hyaluronic acid (HA) recognizing protein (HABR) was used to study whether the human corneal endothelium is covered by HA and to quantify the amount. Tritiated high molecular weight HA was used to determine the capacity of the human endothelium to bind exogenous HA. Human corneas were obtained from keratoconus patients having corneal transplantation and from postmortem eyes. The corneas were immersed in a 4% formaldehyde solution containing 1% cetylpyridine chloride for histochemistry, frozen for biochemistry, or used for 3H-HA (Mr 3 x 10(6) binding. For the biochemical determinations, 125I-labeled HABR was used. Tritiated HA was used for the binding experiment. A specific layer of HA covering the endothelial cells of the corneal buttons was demonstrated. The biochemical analysis also revealed the presence of HA. Finally, the human endothelial cells had specific hyaluronic acid binding sites.

Animals↗