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Biomedical subjects

U Stenram

Publications and source records attributed to U Stenram.

At least 91 records · Page 5Linked to original sources
PubMed1981

A case of papillary-cystic epithelial neoplasm of the pancreas.

A 16-year-old girl presented with a left-sided abdominal mass. X-ray examination and computed tomography disclosed a well-defined tumor close to the tail of the pancreas, stretching the pancreatic branches from the splenic artery as demonstrated by arteriography. Ultrasonography suggested a partly cystic character. Cytologic fine-needle biopsy, histopathological and electron microscopical examination disclosed a cysto-papillary tumor, probably benign, and of an exocrine, ductular origin, and with pseudo-cystic areas similar to those found in adenoid cystic carcinoma of salivary glands. Immunohistochemistry did not demonstrate the presence of polypeptide hormones. The patient is without signs of tumor recurrence 18 months after operation.

Adolescent↗
PubMed1980

Free and membrane-bound ribosomes and NADPH-cytochrome C reductase activity in the liver cells of protein-fed and protein-deprived rats.

Rats were starved for 7 days or fed a protein-free or a 25% casein diet for 7 or 14 days. Free and total ribosomes were prepared from the liver. A determination of the ratio of mg RNA of ribosomes to mg DNA of the total homogenate was made. In starved rats, RNA of free and membrane-bound ribosomes decreased to the same extent. In rats fed a protein-free diet only mg RNA of membrane-bound ribosomes decreased significantly, and after 14 days the ratio of RNA of free to total ribosomes was increased. NADPH-cytochrome c reductase activity in the liver decreased per mg DNA in protein deprivation but was unchanged per mg RNA of membrane-bound ribosomes.

Animals↗
PubMed1979

Adenoma of parotid gland with sebaceous and oncocytic features.

A parotid tumor having sebaceous differentiation and a particular histologic picture previously undescribed is reported. The tumor showed features of an adenolymphoma but almost completely lacked a lymphoid component. Sebaceous differentiation was seen in the epithelium of many cysts. Additionally, groups of oxyphilic cells were scattered throughout the tumor. The literature concerning sebaceous differentiation in normal and tumor bearing parotid glands, as well as that concerning tumors with some sebaceous component, is briefly discussed.

Adenoma↗
PubMed1979

Hepatic necrosis in the pig produced by transient arterial occlusion.

The effects of transient liver ischaemia were studied in young pigs. At operation, a specially designed ligature sling was placed around the hepatic artery and brought out through the abdominal wall so that it could be later tightened. All other routes of arterial supply to the liver were divided. The arterial supply was occluded for 1, 2, 4 or 12 h on the 1st and 3rd postoperative days. Ischaemic damage was assessed histologically and by serum ASAT and acid hydrolase levels. Liver necrosis developed after 1--2 h of occlusion and increased after 4 and 12 h of occlusion. Ischaemic liver damage was reduced when the operation and occlusion were separated by 72 hr.

Animals↗
PubMed1977

Ribonucleic acid labelling perfused livers of protein-fed and protein-deprived rats.

Several observations suggest an increased RNA synthesis in livers of protein-deprived rats, though the RNA/DNA ratio is decreased. A number of hormones may be involved in these changes. Therefore, we studied in RNA metabolism in isolated perfused livers taken from protein-fed and protein-deprived rats. (3H)-orotic acid was given to the rats 2 h before liver explantation, and (14C)-orotic acid was added to the perfusate. Other rats, called controls in vivo, whose livers were not transplanted were also given (3H)-orotic acid followed by (14C)-orotic acid. The livers of these rats, which were not hormone supplemented, were labelled for the same length of times as the livers in vitro. The ratio specific RNA radioactivity/specific nucleotide radioactivity x RNA/DNA was determined and taken as a measure of the RNA synthesis per liver cell. In the controls in vivo, this ratio was significantly higher for protein-deprived than for protein-fed rats. In livers from the protein-fed rats, labelling in vitro increased significantly when growth hormone, hydrocortisone, insulin and tri-iodothyronine were added to the perfusate. Labelling was also significantly higher in these livers than in the controls in vivo. In livers from protein-deprived rats, the ratio in question was the same whether the hormones were added to the perfusate or not, and was significantly lower than in the controls in vivo. Differences in RNA labelling are thus obtained in our in vitro system. Gel electrophoresis of RNA demonstrated normal RNA labelling, showing that the system is suitable for studying liver RNA synthesis. Further refinement can be made by studying the labelling of UTP and CTP. The results might suggest that the liver from a protein-fed rat, explanted in vitro, may increase its RNA synthesis under the influence of the four hormones in question, and that the RNA synthesis of the liver of a protein-deprived rat is high in-vivo and that it might decrease, when it is explanted to in vitro conditions.

Animals↗
PubMed1976

Acute pancreatitis and hepatic necrosis in the acute afferent loop syndrome. A histopathological study in the rat.

The morphological changes in the liver and pancreas during the first 12 hours in the acute afferent loop syndrome were studied in rats with a Billroth II gastric resection. Two essentially different types of changes were found in the pancreas. One was a coagulative necrosis without an inflammatory reaction, which has been found after instillation of bile, bile salts and the detergent sodium lauryl sulphate into the pancreatic ducts. The other type of pancreatitis was an intense, acute purulent inflammation often with bacteria visible in the histological sections. In the liver, large areas of necrosis were often encountered, sometimes mixed with polymorphonuclear leukocytes and bacteria, in a few cases combined with thrombi in small portal veins. The changes in the pancreas occurred very rapidly; only 4 hours after occlusion of the afferent loop there were signs of pancreatitis in some cases and 12 hours after occlusion there was an acute pancreatitis in all cases.

Acute Disease↗
PubMed1976

A new pattern of multiple endocrine adenomatosis: chemodectoma, bronchial carcinoid, GH-producing pituitary adenoma, and hyperplasia of the parathyroid glands, and antral and duodenal gastrin cells.

A female patient was found to have a chemodectoma, a GH-producing pituitary tumour and a bronchial carcinoid combined with hyperplasia of the parathyroids and of antral and duodenal gastrin cells. This combination of endocrine tumours and hyperplasias does not fit with the two multiple endocrine adenomatosis syndromes recognized at present. The case stresses the importance of scanning the patient for other endocrine tumours, once one has been diagnosed.

Adenoma↗
PubMed1975

Bone marrow biopsy of the posterior iliac crest with Gidlund's instrument in malignant diseases.

The bone marrow was examined on material obtained with the Gidlund trephine and with conventional cytologic bone marrow aspiration in 225 patients with malignant disease, 144 of whom had malignant lymphoma, and in 5 patients with haematological, non-malignant disease. With Gidlund's instrument, the malignant disease to 7 cases with needle biopsy. No complications were met with either technique. Bone marrow biopsy was routinely performed in the out-patient department.

Biopsy, Needle↗
PubMed1975

Focal nodular hyperplasia of the liver, benign hepatomas, oral contraceptives and other drugs affecting the liver.

Due to the claim of an association between focal nodular hyperplasia of the liver, benign hepatomas and oral contraceptives, the files in the departments of pathology at the university hospitals in Lund and Malmö were examined for these two diagnoses made since 1945 and 1957, respectively. 26 cases of focal nodular hyperplasia of the liver and 7 benign hepatomas were found, 18 and 2, respectively, in women. Since 1963, the year before oral contraceptives were introduced in Sweden, focal nodular hyperplasia has been diagnosed in 8 women in the reproductive period of life; 4 of these had taken oral contraceptives. The 4 diagnoses were established in 1972-1974. At most, 25 per cent of Swedish females between the ages of 15 and 44 years have been on oral contraceptives. The Swedish series of 28 patients with focal nodular hyperplasia comprised 3 epileptics and 3 diabetics. At least two of the epileptics had been treated with barbiturates and/or hydantoins. The prevalence of drug-treated epilepsy in Sweden is 0.4-0.5 per cent, and of diabetes about 2 per cent. The possible aetiological role of drugs provoking an increase of the smooth-surfaced endoplasmic reticulum of the liver and proliferation of vascular fibrous tissue in a part of the liver which preveiously may have been damaged by vascular disturbances or trauma, is considered. No relationship between benign hepatomas and drugs was found. The observations support the notion that oral contraceptives may be of aetiological importance in the development of focal nodular hyperplasia of the liver, although the material is too small for epidemiological and statistical analysis.

Adolescent↗
PubMed1975

Elevated serum growth hormone in protein-deprived rats, and decreased liver RNA after hypophysectomy.

Serum growth hormone was significantly higher in rats fed on a non-protein than on a 25% casein diet. In both dietary groups, hypophysectomy provoked a decrease in the RNA/DNA ratio of the liver, and, especially in the protein-deprived rats, a decrease in the RNA synthesis per liver cell, measured as the product of the RNA/DNA ratio, and the ratio of specific RNA activity to specific nucleotide activity, two hours after administration of [3H]orotic acid. In the protein-deprived rats, full reconstitution of these figures was obtained with a combination of growth hormone, hydrocortisone and triiodothyronine, but not quite with growth hormone alone. The possible role of growth hormone in protein deprivation is discussed.

Animals↗
PubMed1975

Alpha-1-antitrypsin deficiency, mitochondrial antibodies and possible primary biliary cirrhosis. A case report and family study.

A case of a 70-year-old woman with a history of gastric ulcer and several pneumonias is presented. She was found to have pulmonary emphysema, severe alpha-1-antitrypsin (alpha1AT) deficiency and raised serum mitochondrial antibodies. Surgical liver biopsy showed portal liver cirrhosis, PAS-positive, diastaseresistant globules in the hepatocytes and changes interpreted as florid duct lesion of primary biliary cirrhosis. A brother has severe alpha1AT deficiency. Two daughters had raised mitochondrial antibodies. One of the latter had a granulomatous hepatitis, a common finding in primary biliary cirrhosis. The association of alpha1AT deficiency and primary biliary cirrhosis does not seem to have been described previously.

Adolescent↗