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Biomedical subjects

U Stosiek

Publications and source records attributed to U Stosiek.

At least 19 recordsLinked to original sources
PubMed2002

Adjuvant endocrine treatment with medroxyprogesterone acetate or tamoxifen in stage I and II endometrial cancer--a multicentre, open, controlled, prospectively randomised trial.

Endometrial cancer is a hormone-dependent disease and therefore an adjuvant hormonal therapy might improve the outcome in the early stages of the disease. Between 1983 and 1989, we conducted a randomised trial of 388 patients who received either medroxyprogesterone acetate (MPA) (n=133) or tamoxifen (n=121) orally for 2 years, or were observed only (n=134) after surgical therapy. The aim was to evaluate whether an adjuvant treatment can improve disease-free and overall survival rates. After a median follow-up period of 56 months (range 3-199 months), we observed no differences in the disease-free and overall survival rates for the tamoxifen group compared with the control or the MPA group. Side-effects were more frequent and severe in the MPA-group than in the tamoxifen group. In patients with early endometrial cancer, adjuvant endocrine treatment did not significantly improve the outcome. However, tamoxifen did have some beneficial effects on coexisting morbidity.

Adult↗
PubMed1997

Low frequency of BRCA1 germline mutations in 45 German breast/ovarian cancer families.

In this study we investigated 45 German breast/ovarian cancer families for germline mutations in the BRCA1 gene. We identified four germline mutations in three breast cancer families and in one breast-ovarian cancer family. among these were one frameshift mutation, one nonsense mutation, one novel splice site mutation, and one missense mutation. The missense mutation was also found in 2.8% of the general population, suggesting that it is not disease associated. The average age of disease onset in those families harbouring causative mutations was between 32.3 and 37.4 years, whereas the family harbouring the missense mutation had an average age of onset of 51.2 years. These findings show that BRCA1 is implicated in a small fraction of breast/ovarian cancer families suggesting the involvement of another susceptibility gene(s).

Adult↗
PubMed1987

[Prognostic value of sonography in breast cancer].

The prognostic value of sonography was tested in 108 cases of breast carcinoma. The criteria of prognosis were the low-risk and high-risk groups of histological and cytological gradings, the positive or negative hormone receptors as well as the nodal positive and nodal negative clinical stages. In the low risk group there were mostly elderly women with smaller carcinoma. Under the sonography these tumors were polycyclic and had a dorsal ultrasonic shadow. In the high risk group were younger women with bigger tumors. When scanned they mostly showed branches, a lateral ultrasonic shadow and sound intensification. In general, the different risk groups couldn't be clearly distinguished by sonography. As high disintegrate scanners have not been used long enough, there are no studies to prove their accuracy. We suppose, however, that the accuracy of prognosis can be improved with the new generation of scanners.

Adult↗
PubMed1987

Of false negative results in the ultrasound of female breast cancer.

The preoperative results of sonography of 108 malignant breast tumors were analysed for reasons of false negative results by correlation of sonographic features with the corresponding clinical, histological and cytological findings. Previously we found no typical sonographic criteria of malignancy. Here we show, that diagnosis was especially difficult in carcinoma of young women, and in estrogen receptor negative, as well in progesterone positive tumors. The accuracy of diagnosis of tubular carcinoma was lower than of solid carcinomas. There was no correlation between false negative ultrasound results an histological or cytological grading, nuclear size, or tumor mitosis rate. We emphasize the importancy of sonography in diagnosis of female breast cancer.

Adult↗
PubMed1986

[Correlations between sonographic and clinical findings in breast cancer].

We recorded the sonographic findings of 108 cases of carcinoma of the breast and compared the different criteria with the respective histological and clinical parameters. When scanned, carcinomas of the breast usually presented as irregular carcinomas with good sound conduction, few internal echoes and rarely with a lateral or dorsal ultrasonic shadow. Sonography showed a smaller diameter of the tumours than measured histologically. Medium-size and solid carcinomas with a smooth surface could be distinguished mos easily. Histological and cytological grading classified these tumours in the high risk group. Tubular and scirrhous tumours were significantly less easy to identify and delineate. This applies also to bigger and smaller tumours. In most cases small carcinomas were smooth, were likely to show sound intensification, and rarely had a dorsal ultrasonic shadow. The bigger they became, the more often we could observe branches; sound intensification decreased, and the dorsal ultrasonic shadow increased. Carcinomas of young women had the same sonographic characteristics as small tumours, whereas carcinomas in elderly women had those of big tumours, although there was no correlation between age and the size of the tumours. We emphasise the importance of sonography in determining tumours dynamics.

Adenocarcinoma↗
PubMed1986

[Growth dynamics of breast cancer. Comparison of cytohistologic parameters of the primary tumor, lymph node metastases and recurrent tumors].

The dynamic of tumor growth has been estimated in breast cancer using cytologic and histologic criteria. There were definite differences between primary tumors with simultaneously observed metastases and tumors which had metastasized within the first two years following primary treatment. The primary tumors of the recurrent diseases were receptor positive more seldom, and they had a significant lower receptor concentration. Morphologically they were composed of larger cells with polymorphism and more mitoses. Between primary tumors and metastases there were no significant differences. We suspect the grade of malignancy is a typical attribute of a tumor not changing after having metastasized or recidivation. Changing tumor growth is caused by other reasons like general resistance.

Breast Neoplasms↗
PubMed1984

[Abnormalities of the upper gastrointestinal tract diagnosed prenatally by ultrasound].

A hydramnion occurring during the second half of pregnancy may be due to atresias in the upper intestinal tract. Generally, one case of oesophageal atresia is likely to occur in every 2,500 births, often together with other malformations. Prenatal diagnosis of such atresias substantially improves prognosis for these children via optimal cooperation between the obstetrician and the paediatric surgeon. Characteristic features of oesophageal atresia in the sonographic image are, besides the hydramnion, the absence of visualisation of the stomach. Sonographic diagnosis of duodenal atresias is based on visualisation of the stomach, which is excessively filled with fluid, and of the portion of the small intestine located cranially of the stenosis. The patients treated by the author and presented here were successfully operated on via termination of birth and immediate surgery by the paediatric surgeon.

Adult↗
PubMed1984

[Cytological changes in breast carcinoma in situ].

Certain preinvasive stages precede invasive carcinoma of the breast. Our knowledge about diagnostics, development and prognosis of such preinvasive forms is poor, for it is not possible to observe them directly and continuously. Analysis of the fine needle aspirates of carcinomata in situ of the breast show suspicious apocrine metaplastic cells with nucleoli in 92% and foam cells in 75%, being in contrast to cytological findings on benign lesions. Those peculiarities are more obvious with CLIS than with intraductal CIS lesions. They can be interpreted as particular signs of increased cell proliferation, and, in cases of doubt, should lead to a surgical treatment of suspicious lesions of the breast.

Adenofibroma↗
PubMed1984

[Correlation of estrogen receptors and histologic and cytologic grading of breast cancer].

Correlations between estrogen receptors and other prognostic criteria have been examined. These criteria are clinical extent, status of lymph nodes, histologic differentiation, histologic and cytologic grading. Cancers with a good prognosis are much more receptor positive than those with a bad prognosis. The quantity of receptors does not allow any prognostic statement. Possible reasons for it are discussed.

Breast Neoplasms↗
PubMed1983

A prospective study of cytological prognosis in breast cancer: the cytological grading.

Improved early diagnosis and utilization of new procedures for postoperative treatment of breast cancer have made it possible, especially in the case of small tumors, to depart from the orthodox radical operative procedures. In planning a proper therapeutic approach, preoperative diagnosis plays an ever increasing role. In a prospective study 103 cases with cytologically and histologically verified carcinoma of the breast were subjected to cytological grading. The parameter for the grading included the dissociation range and polymorphism of the nuclei, the occurrence of nucleoli and the size of the nuclei. The low-risk-group was comprised mainly of older patients with small cell unimorphous, histologically scirrhous or tubular carcinomas. The high-risk-group was comprised mainly of younger patients predominantly with large call polymorphous, histologically solid carcinomas. The results are expected to give insight into tumor dynamics as well as to be to of therapeutic relevance.

Adenocarcinoma, Scirrhous↗
PubMed1982

[Treatment of a prenatally diagnosed chylothorax].

A case of bilateral fetal chylothorax was diagnosed by ultra-second at 34 weeks gestation. The pregnancy had shown marked hydramnios. The ultrasound examination showed massive pleural effusions with marked compression of the both lungs a low diaphragm and a normal sized heart. After administration of Dexamethasone for pulmonary maturation a primary Caesarean section was done at 37 weeks pregnancy, the newborn was immediately intubated and the pleural effusions suctioned by bilateral pleural drainage. The lungs expanded satisfactorily, the drainage was removed 2 weeks later and the infant developed normally.

Cesarean Section↗
PubMed1980

[Statistical studies on thrombotic complications and the incidence of endocarditis neoplastic diseases].

On the basis of data gained by autopsy the frequency of thrombotic and thromboembolic complications (TTK) was investigated by correlation analysis in unselected malignant tumour diseases and in malignant tumour diseases with tumour endocarditis (TE). The following things could be detected: 1. No increase of TTK in malignant tumour diseases compared with the total material, 2. A significant increase of TTK in tumours with TE, 3. A significant increase of TTK with an increasing histological tumour differentiation and an increasing inflammatory current reaction of the tumour, and 4. Parallel behaviour of tumours with TTK and those with TE concerning primary tumours. TTK was interpreted as the cause of an abnormally enhanced tendency of blood coagulation on the basis of an immunocomplex disease, because: 1. The coagulation system is being activated by circulating immunocomplexes, 2. Circulating immunocomplexes will increase with tumour parameters, differentiation, and current reaction, and 3. Frequency of TTK and TE will increase with the same parameters.

Antigen-Antibody Complex↗
PubMed1979

[Prevention of thrombosis during therapy of gynecologic neoplasms].

Blood coagulation, but especially diagnosis, prophylaxis and therapy of thromboembolic complications are of special importance in gynaecology. Besides connatal factors acquired factors are to be considered. Carcinomas enhance hypercoagulation, especially if x-ray treatment is performed. There exists a great number of diagnostic and therapeutic possibilities, though adequate prophylaxis is much more efficient than extensive diagnosis. Among the many possibilities of prophylaxis of thromboembolic complications the subcutaneous application of heparin in subclinical doses is especially efficient. Application is simple, paractically painless, additionally healing is enhanced by heparin.

Coumarins↗
PubMed1977

[Lymphografy--a meaningful diagnostic method for classification of gynaecological tumours (author's transl)].

The data about the significance of lymphografy vary between 50% and 90%. The histological findings of the lymphnodes by patients with carcinoma of the cervix uteri operated according to the method of Wertheim-Meigs showed that the findings of lymphografy agree in 68% of the cases with the histological ones. An agreement of lymphografy and histological diagnosis however had been demonstrated in 84% of the cases when there was more than a suspect praetherapeutic lymphografical finding. Although the indication of lymphografy as a searching method is reasonably doubtful in early cancer cases this possibility of an exact verification of the extension of the tumour should not be neglected. An exact praetherapeutic exploration about the consistance of the lymphonodes is of great importance of an optimal therapeutic effect. The presented data show that the lymphografy should be applicated by patients with gynaecological carcinoma if there is no contraindication.

Female↗