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Biomedical subjects

U T Danielsen

Publications and source records attributed to U T Danielsen.

10 recordsLinked to original sources
PubMed1990

Regional cerebral blood flow in chronic alcoholics measured by single photon emission computerized tomography.

Regional cerebral blood flow (CBF) was measured by single photon emission computerized tomography of inhaled 133-Xe in 20 chronic alcoholic men. Mean CBF was 51 ml/(100 g x min) compared with 53 ml/(100 g x min) in 20 normals. Reduced cerebellar blood flow correlated both to structural abnormalities seen on CT scan and to cognitive dysfunction. Slight abnormalities of the regional CBF was observed in the alcoholics. They had a higher incidence of regional low flow areas than a control group. Low flow areas were found in frontal and posterior parts of the brain not only in patients with atrophia, but also in patients without CT abnormalities, suggesting neuronal dysfunction. The occurrence of regional low flow areas was associated with the severity of alcoholism, cerebral atrophy and intellectual impairment.

Adult↗
PubMed1989

Nervous system damage and nutritional factors in chronic alcoholics.

Dietary habits in 45 chronic alcoholics were assessed by the dietary history method, and plasma albumin and serum transferrin. These variables as well as clinical findings did not indicate general malnutrition, but a moderate deficiency in folate intake was found. There was no correlation between the nutritional variables and central and peripheral nervous system function investigated by neuroradiological, neuropsychological, and neurophysiological methods. Transketolase and thiamine-pyrophosphate effects were measured in a subgroup of alcoholics and compared to a control group. No differences were found and there was no correlation to central nervous system impairment. These findings do not support the hypothesis that nervous system damage found in chronic alcoholics is of nutritional etiology.

Adult↗
PubMed1984

Peripheral neuropathy, cerebral atrophy, and intellectual impairment in chronic alcoholics.

Peripheral neuropathy, cerebral atrophy, and intellectual impairment was investigated in 46 males with alcoholic nervous system damage. An overall correlation was found between peripheral neuropathy and cerebral atrophy and between several of the individual neurophysiological and neuroradiological variables examined. There was also a correlation between cerebral atrophy and intellectual impairment. The findings support the view that alcohol in itself is toxic to central and peripheral nervous tissues, although a dose-response dependence could not be established.

Alcoholism↗
PubMed1981

Denial and neglect of hemiparesis in right-sided apoplectic lesions.

In a prospective investigation of 55 consecutively selected patients with right-sided apoplectic lesions, denial and neglect of hemiparesis was registered in a standardized way using fixed criteria. The patients were all fully conscious and could cooperate in a detailed investigation. About half of the patients had denial and neglect of hemiparesis (1/4 denial, 1/5 neglect). The syndrome(s) of denial/neglect was not related to sensory defects or defects in the sense of position. Denial of hemiparesis was related to extent of lesion, neglect of hemiparesis was not. Both syndromes were related to age of patients. The resemblance between denial and neglect of hemiparesis is pointed out. It is argued, that the two phenomena could be seen as one syndrome released by right-sided brain lesions, the difference being a matter of degree. The cognitive factors in denial/neglect are thought upon as factors, than can be seen in right-sided lesions together with paresis, visual defects, but apparently not necessarily associated with the named defects.

Age Factors↗
PubMed1981

Visual neglect in right-sided apoplectic lesions.

Fifty-five patients with right-sided apoplectic brain lesions prospectively and consecutively collected, were analyzed as to the frequency of visual neglect. The syndrome was present in 18 patients, 10 of whom had left hemi- or quadrantanopia. In addition, two patients had anopia with Anton's syndrome. Only the visual neglect without field defects was closely related to denial of hemiparesis. The two components of the syndrome of visual neglect, defects in registering visual information from the left side and defective appreciation of own condition are described and analyzed. Psychological theories of the processes behind the syndrome of neglect have difficulties in joining the cardinal features of the syndrome satisfactorily. Theories on the specific role of the right hemisphere in connection with attention/arousal and complex gnostic functions are referred to in the discussion of the syndrome.

Aged↗
PubMed1979

Syphilitic normal pressure hydrocephalus.

We report a case of presenile dementia with radiological and cisternographical features suggesting normal pressure hydrocephalus, caused by syphilitic infection. Treatment with penicillin resulted in considerable regression of the neurological and psychological signs.

Brain↗