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Biomedical subjects

U Thisyakorn

Publications and source records attributed to U Thisyakorn.

At least 19 recordsLinked to original sources
PubMed1994

Diseases caused by arboviruses--dengue haemorrhagic fever and Japanese B encephalitis.

Dengue haemorrhagic fever is a recent and more serious variant of dengue infection, causing significant mortality in children under 14 years of age in South-East Asia and the Western Pacific regions. Successful treatment depends on early recognition of the disease and careful monitoring of the development of shock. Japanese B encephalitis has a case fatality rate of 10%-30% in these regions, but may be controlled by vaccination.

Capillary Permeability↗
PubMed1994

Dengue infection complicated by severe hemorrhage and vertical transmission in a parturient woman.

A Thai woman with a febrile illness was delivered of a healthy infant by cesarean section. The etiology of her 2-day fever was unknown at the time of surgery; results of serology performed later established a diagnosis of dengue infection. Postoperative hemostatic monitoring was not performed. She experienced massive and prolonged (8 days) wound hemorrhage that necessitated multiple transfusions of blood, platelets, and frozen plasma. The newborn became febrile on his 6th day of life. Dengue virus type 2 was isolated from his serum. Although the infant developed marked thrombocytopenia, his illness was brief and uncomplicated. This report emphasizes the hazards of surgical intervention in patients with acute dengue infection. We also believe it to be the first report of vertical transmission of dengue in humans.

Adult↗
PubMed1994

Dengue infection with unusual manifestations.

In 1987, 505 serologically confirmed dengue infection patients were admitted to the Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand. Fourteen patients had unusual manifestations which were mostly encephalopathic and hepatopathic. Patients who had unusual manifestations tended to be in the younger age group and had higher mortality.

Adolescent↗
PubMed1993

Nutritional status of children with dengue hemorrhagic fever.

Nutritional status was assessed for 100 patients with serologically confirmed dengue hemorrhagic fever (DHF), 125 patients with other infectious diseases who were admitted to Children's Hospital (Bangkok), and 184 healthy children. The assessment was done with use of the following parameters: weight for age, height for age, and circumference of the middle of the left arm. There were 13 patients classified as undernourished by weight for age, nine of whom were determined to have first-degree malnutrition; six of these had grade II severity of DHF and three had grade III DHF severity. Four patients, two each of grade II and III DHF severity, had second-degree malnutrition. All were considered to be healthy when nutritional status was assessed by height for age and mid-left arm circumference. The prevalence of 13% malnutrition found among patients with DHF is significantly lower than the prevalence of malnutrition found among patients with other infectious diseases and among healthy children. The study confirmed the observation generally made that most patients with DHF are not undernourished.

Adolescent↗
PubMed1993

Safety and immunogenicity of Salmonella typhi Ty21a vaccine in young Thai children.

Salmonella typhi Ty21a vaccine in a liquid formulation was evaluated in 634 Thai children 2 to 6 years of age. The seroconversion rate was 69% for those who received vaccine versus 14% for those who received placebo (P < 0.005). The immune responses among vaccine recipients ranged from 60% in 3-year-olds to 81% for 6-year-olds.

Age Factors↗
PubMed1991

Determination of teichoic acid antibody for the diagnosis of pediatric staphylococcal infections.

Determination of teichoic acid antibodies by Enzyme-linked Immunosorbent Assay (ELISA) was done in 39 patients with Staphylococcus aureus infections and 151 patients who did not have a history of serious staphylococcal infections. The latter who were treated for other diseases served as controls. Various levels of teichoic acid antibodies below 1:3,200 were detected in controls while significantly higher levels were seen in patients with Staphylococcus aureus infections.

Adolescent↗
PubMed1987

Typhoid and paratyphoid fever in 192 hospitalized children in Thailand.

From 1977 to 1984, Salmonella typhi was isolated from 85% and Salmonella paratyphl A was isolated from 15% of 192 Thai children with enteric fever at Children's Hospital, Bangkok. Children with enteric fever presented with sudden onset of fever and gastrointestinal symptoms. of fever presented with sudden onset Diarrhea occurred in 62% of children with paratyphoid fever and 36% of children with typhoid fever. Rose spots were seen in 15% of patients with typhoid and 7% of patients with paratyphoid fever. There were no deaths. Bronchitis and pneumonia occurring in 11% of patients were the most common complications. Acute hemolysis occurred in 3% of the patients with typhoid fever who had thalassemia or glucose-6-phosphate dehydrogenase deficiency. Chloramphenicol-resistant S typhi, which accounted for 70% of the isolates in 1977, has since 1982 accounted for less than 2% of isolates.

Adolescent↗
PubMed1987

Dengue haemorrhagic fever with unusual manifestations.

A retrospective study on 18 cases of DHF presented with jaundice and neurological signs which were considered unusual manifestation of DHF reveals that the causes or contributing factors are multifactorial. Most commonly found associated conditions were prolonged shock with metabolic acidosis and severe DIC that lead to hypoxia/ischaemia and resulted in both hepatic and brain dysfunction. Gross haemorrhage in the brain was noted in 6 of the 10 fatal cases while brain oedema was noted in 3 cases. Electrolyte disturbance such as hyponatremia could be another cause of brain oedema. It is certain from this study that there is no pathological evidence of encephalitis. Hepatic dysfunction found in associated with jaundice and encephalopathy is possibly caused by toxic substances, drugs and/or associated with underlying liver conditions. Reye's or Reye's-like syndrome was postulated in one case.

Brain Diseases↗