[Anguilla skin: a new substrate for the study of transmucosal mucoadhesion and permeation].
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Biomedical subjects
Publications and source records attributed to U Urbano.
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Recurrent, cytologically benign pleural effusion was, for a long time, the only clinical manifestation of Hodgkin's disease involving the inner thoracic wall in the reported case. It is the first case reported in literature.
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Two autopsy cases of angioimmunoblastic lymphadenopathy with dysproteinemia were examined. Clinical and morphological data did not differ greatly from those in other cases of the literature: patients died two and three months after the onset of the symptoms. The autopsy findings included moderately enlarged generalized lymph nodes, hepatosplenomegaly and lungs involvement. Microscopically the most prominent change was the vascular proliferation with pleiomorphic cellular infiltration.
Mesonephric adenocarcinoma of the bladder is an extremely rare neoplasm. The typical location in the bladder neck and trigone tends to confirm that this neoplasm probably derives from a remanent of the mesonephric duct. This case is the fourth described in the literature. The patient underwent total cystectomy with ureterosigmoidostomy and is still apparently tumor free 7 years after operation.
The true struma ovarii is a rare teratomatous neoplasia, composed with typical thyroid tissue. Generally it is asymptomatic or only determines a mild hypogastric weighting feeling. In a few subjects this neoplasm is secreting and rise to hyperthyroidism. The Authors describe the clinical and anatomopathological characteristics of 3 cases of true struma ovarii come to their observation. No malignant histologic features in any of them was seen. In the relatively short period of post surgical observations no women showed relapses or metastases. This confirms that true struma ovarii is usually a benign tumor.
Brenner's tumor is a rare fibroepithelial ovarian neoplasia, histologically characterized by an epithelial component similar to the transitional epithelium of the urinary tract. The histogenesis of neoplasm, which only rarely secretes estrogens, is still controversial. The Authors describe the clinical and anatomopathological features of six cases come to their observation. Only one of these was malignant; the woman died 18 months after diagnosis. There is no strict correlation between histological picture and biological behaviour. Only this one can give assurance on the benign or malignant nature of Brenner's tumor.
The Authors report a critical review of all the cases of ovarian neoplasia observed in the provinces of Pisa, Livorno, Lucca and La Spezia between 1976 and 1981. This study does not take into account all the cases in which incomplete clinical and histologic data were available or the first histologic diagnosis was not confirmed by a second examination. The incidence rate and distribution characteristics of all the histologic types of ovarian neoplasia are described.
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The case of a 72 year old woman with primary malignant melanoma of the esophagus, subjected twice to surgical operation with a 17-month interval and still alive 35 months after the onset symptoms is reported. In order to outline the biologic behaviour of this rare neoplasm, 44 similar bibliographic cases are analysed and comparisons made between melanoma and carcinoma of the esophagus as well as between melanomas of the esophagus and of the skin.
Sarcoid type granuloma have been observed in lymph nodes with Hodgkin's disease. Several pathogenetic hypotheses have been considered, and finally the picture has been interpreted as the epithelioid form of Hodgkin's disease.
The occurrence of 392 lymphomas in 1607 BALB/cfRIII mice from F0 to F45 is analyzed. Lymphoma incidence increased rapidly in the first 5 generations, reached a high plateau from F6 to F20 and then decreased slowly until it disappeared altogether. After F35, only sporadic cases of lymphoma have been observed. The morphologic characteristics of 350 of these lymphomas observed from F0 to F20 are described. Three main types of lymphomas have been recognized on the basis of gross morphology, histology and age: a) early, lymphocytic, with thymic involvement; b) early, lymphocytic, without thymic involvement; and c) late, histiocytic, without thymic involvement. The first 2 types are virus-induced and thymus-dependent, and the third type is both virus and thymus independent. Lymphomas without thymic involvement and histiocytic lymphomas increased with the generations. The source of causative virus, the interference with mammary tumors, and the possible cell types of origin of lymphomas are discussed.
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