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Biomedical subjects

U Voigt

Publications and source records attributed to U Voigt.

At least 19 recordsLinked to original sources
PubMed1989

[The course of ovulation in gilts after the use of two GnRH injections for ovulation stimulation].

The status of ovulation and amount of ovulated follicles in 410 gilts which had received differentiated pretreatment produced evidence to the feasibility of substitution of HCG by Gn-RH vet. "Berlin-Chemie" to stimulate ovulation. Yet, 2 injections are necessary with an adequate interval between them and with appropriate dosage. The highest synchronisation effect in all experimental variants was obtained from 350 and 750 micrograms of Gn-RH with 50 minutes in between or 750 plus 750 micrograms of Gn-RH with an interval of 40 minutes. Ovulation was most reliably stimulated by 500 I.U. of HCG.

Animals↗
PubMed1986

[Antimicrobial chemoprevention in colorectal interventions: a single parenteral dose at the start of surgery is adequate].

The effectivity in reducing septic complications after colorectal operations of oral 1 g Neomycin plus 0.25 g Metronidazol t.i.d. on the last preoperative day vs. intravenous single dose 5 g Mezlocillin plus 0.5 g Metronidazole was tested by sequential medical plan. There was no statistically significant difference between both chemoprophylaxis groups (p = 0.10). It is concluded that the intravenous chemoprophylaxis should be preferred because of the lowest dosage and therefore the fewest side-effects.

Administration, Oral↗
PubMed1985

[Effect of perioperative antibiotics on septic complications following emergency interventions on the small and large intestine].

The effect of perioperative antibiotics on septic complications in emergency bowel surgery was studied by reviewing the charts of patients. The rate of septic complications was essentially reduced in patients, who had received antibiotics pre-, intra- or immediately postoperatively compared with patients without any antibiotic medication (without antibiotics [n = 25] 6 abdominal wound infections, 5 lethal anastomotic disruptions, 2 urinary infections; with antibiotics [n = 24] 0 abdominal wound infections, 2 lethal anastomotic disruptions, 1 urinary and 1 pulmonary infections). Because of the significant reduction of abdominal wound infections which could be achieved in treating patients (X2 = 6,56; p less than 0,05) with antibiotics, these medicaments should be given in emergency bowel surgery with a further prospective controlled study being not necessary.

Abdomen, Acute↗
PubMed1983

Results of quality control surveys of radioimmunological determinations of thyrotropin in newborns.

Within the quality control scheme of the Deutsche Gesellschaft für Klinische Chemie, seven quality control surveys of thyrotropin (TSH) determinations in blood dried on filter paper have been carried out since 1980. Ninety-six screening laboratories from 12 European countries took part in these surveys. In a single survey each participant usually analysed four different samples; each of these consisted of three spots of dried blood spiked with defined amounts of thyrotropin. For the evaluations of the surveys the participants were asked to give information about their analytical results, and from these, their diagnostic classifications. The medians of the analytical results correlated well with the given thyrotropin concentrations, but the individual estimations from different laboratories varied greatly. Major discrepancies of classification were also apparent, both in the given thyrotropin concentrations and in the individual estimations. Two special collaborative studies with nine selected laboratories showed on the one hand that analysis of the largest possible part of the dried blood sample can help to optimize the precision of the results; on the other hand, considerable drawbacks related to the reagents and the methods were sometimes observed.

Blood Specimen Collection↗
PubMed1983

[Collaborative tests of steroid hormone determinations: accuracy and precision of analytic results].

In the years 1977 to 1981, 14 quality-control surveys for the determination of steroid hormones were performed in cooperation with the Deutsche Gesellschaft für Klinische Chemie. Hereby the laboratories participating could in each case analyze the following steroids: aldosterone, cortisol, oestradiol-17 beta, oestriol, progesterone, and testosterone. In the light of the results an investigation was made as to whether, in the course of time, an improvement in the accuracy or in the precision of the determinations had been attained, and to what extent the determinations depend on the qualities of the test material. A clear improvement in the accuracy of the results of the analyses could only be ascertained for oestradiol-17 beta. For aldosterone and cortisol, values were found in pool-plasma whose medians were significantly above the definitive values. An improvement in precision could be noted especially with oestradiol-17 beta and to lesser degrees with cortisol and oestriol. The kind of test material--plasma which contained only the hormones to be analyzed on the one hand, and, on the other hand, pool-plasma, which also contained all endogenous hormones--had no influence on the precision of the results from various laboratories. Low concentrations of the individual steroids led--on the basis of the methodological principle of radioimmunoassays--in almost all cases to a reduced interlaboratory precision in regard to values. The accuracy of the analysis values was considerably impaired only with aldosterone and oestradiol-17 beta by low concentrations: the medians here were in part twice as high as the definitive values.

Aldosterone↗
PubMed1982

[Results of quality control surveys for urinary calculus analyses].

In 1980 and 1981, four quality control surveys for urinary calculus analyses were carried out, within the framework of external quality controls of the Deutsche Gesellschaft für Klinische Chemie. During these quality control surveys the participating laboratories received a total of 16 samples (eight pure substances and eight mixtures of two components), to be analyzed qualitatively and quantitatively. For the qualitative analyses, a laboratory could provide simplified descriptions of the analytes - for example, without stating the number of molecules of the water of crystallization; or, to the extent permitted by the mode of analysis, the exact chemical composition could be presented. Of 1283 analyses, 818 (64%) attained the goals of the simplified analysis. The most frequent errors in chemical analyses were false negative and false positive results for calcium oxalate, and false negative results for calcium phosphate. Laboratories using analysis by infrared spectroscopy also submitted the biggest proportion of incorrect analyses for these components. The most reliable results were produced by X-ray-diffraction: 86% of the results in this category represented correct differentiated analyses. The generally accurate results achieved by some participants using chemical analysis suggest, however, that - in addition to the principle of analysis used - the qualification of the operator is an important determinant in the reliability of the results.

Calcium Oxalate↗
PubMed1979

[Detection of antibodies against Aspergillus fumigatus. 1st report: making of antigens (author's transl)].

A method of antigen preparation from Aspergillus fumigatus has been described. We received the antigens from medium and mycel used for the detection of precipitins and IgE-antibodies. The antigenic components are demonstrated in the immunoelectrophoresis. By the use of absorption we did not find essential differences between medium antigen and mycel antigen for the detection of precipitins. The medium antigen recommended for diagnostic is easier to produce and, moreover, has advantages for the detection of specific IgE antibodies.

Antibodies, Fungal↗
PubMed1979

[Ultrasonic biometry of the fetal crown-rump length between 7 and 20 weeks gestation (author's transl)].

In 370 examinations on 258 patients with known gestational age crown-rump length (CRL) of the fetus was determined by sonar between 7 and 20 weeks. From the results the mean and "2 SD" limits of CRL were derived by means of a non linear regression analysis. The measurements were further analysed to determine gestational age for a given CRL. Besides a velocity curve of CRL growth was calculated. It showed a maximum of 1.8 mm per day at 14 weeks. It was confirmated that sonar measurements of crown-rump length are very useful to estimate maturity of the fetus. The accuracy was found to be best in early measurements (+/-6 days at 7 weeks -+/-11 days at 20 weeks). In regard to clinical decisions reading errors have to be taken into consideration. To avoid them control examinations should be carried out.

Anthropometry↗
PubMed1977

The rabies information system--a model for a common information system in human and veterinary medicine.

An information system is described in the field of rabies, which realizes the integration of information streams from human medicine as well as from veterinary medicine by help of computers. This rabies information system is based on a homogeneous and coordinated system of surveillance in connection with prophylaxis and control of rabies. It includes a modification of the case record, suggested by the WHO-Expert-Committee on Rabies. The aims of this rabies information system are: to make obvious the epizootiological situation with formation and change of foci, to show the epidemiological importance of special animals and to recognize the epidemiological situation. All this has to be fulfilled in an integrated system. Furthermore optimal treatment is guaranteed by express diagnostics and earliest possible special treatment of high-risk groups by the co-operation of human and veterinary medicine. The rabies information system was generally introduced in the GDR in 1970. It has proved to be practicable and effective especially by standardization of diagnostics, recording exposure of the patient, his treatment and partly automated evaluations of situation records and documentation of efficiency.

Animals↗
PubMed1977

[Lymphocyte transformation test in the diagnosis of occupational allergy (author's transl)].

In 139 persons occupationally exposed to compounds of chromium, formaldehyde and p-phenylenediamine lymphocytic transformation test (ltt) was performed to detect a delayed-type hypersensitivity. In patients suffering from either contact dermatitis or allergic respiratory diseases the findings of ltt were concordant only in about one third of the cases in comparison to patch testing, intracutaneous test, nasal provocation or inhalation test.

Chromium↗
PubMed1976

[Trypsin-inhibitory - capacity in humans to respirable allergens or irritants (author's transl)].

The trypsin-inhibitory-capacity was measured with a gelatine-film-technique after JAMES et al, in 520 persons suffering from complaints of upper and/or lower airways in connection with exposure to respirable allergens and/or irritants. As a control group 214 blood donors were examined. After determination of normal range, relations to age, sex, smoking habits, ventilatory parameters, bronchial reactivity, sedimentation rate of blood cells, alpha1-globuline and IgE were examined. In workers exposed to enzymes mean values to trypsin-inhibitory-capacity were found to be in normal range. Determination of trypsin-inhibitory-capacity is proposed to be used in examinations of workers who are to be exposed to enzymes.

Adult↗
PubMed1975

[Ultrasound in obstetrics. Marking sheets, documentation, programming of summative data. Translation of code into full text (author's transl)].

Report on system of documentation and electronic data analysis of results of ultrasound examinations as used for 5 years at the obstetric department of Bonn University. Special marking sheets were used for primary data collection. Storage and analysis were handled with the author's own programming language SEQAS (Voigt, 1971). The system has worked well. 4 types of sheets used for coding are shown and program examples given.

Computers↗