PubMed Health⌕ Search

Biomedical subjects

U W Kesselring

Publications and source records attributed to U W Kesselring.

23 records · Page 2Linked to original sources

Effect of temperature and relative humidity on nitrazepam stability in solid state.

The decomposition of a 1% dilution of nitrazepam in microcrystalline cellulose was established by quantitative determination of the two main breakdown products, 2-amino-5-nitrobenzophenone and 3-amino-6-nitro-4-phenyl-2(1H)-quinolone, using in situ diffuse reflectance measurements on thin-layer chromatograms. The decomposition and formation rate constant of nitrazepam and of the breakdown products, respectively, were determined at four temperatures and six relative humidities. By means of a three-parameter regression equation, it was possible to correlate quantitatively the decomposition constant of nitrazepam to both temperature and relative humidity.

Chromatography, Thin Layer↗