PubMed Health⌕ Search

Biomedical subjects

U Waern

Publications and source records attributed to U Waern.

At least 19 recordsLinked to original sources
PubMed1990

Increased whole blood viscosity combined with decreased erythrocyte fluidity in untreated patients with essential hypertension.

Erythrocyte fluidity and other haemorheological variables were studied in 22 patients with essential hypertension and compared with age- and sex-matched healthy controls. Hypertensive patients displayed a significantly lower erythrocyte fluidity (P less than 0.001). Similarly, significantly elevated values for haematocrit, plasma and whole blood viscosity, as well as aggregation tendency were observed compared to controls. Although differing in these respects from controls, there were no obvious relationships between these rheological variables and either systolic or diastolic blood pressure. The significantly lower erythrocyte fluidity and other changes in haemorheological variables of red blood cells found in hypertensive patients may be explained by an enlarged metabolic pool of free calcium ions in these red blood cells. It is suggested that the molecular mechanisms underlying the evolution of essential hypertension are multifactorial rather than being based on a single molecular derangement. Primary events resulting in altered physicochemical properties of the red blood cells may work in concert in the development of essential hypertension, in addition to the increased availability of calcium ions and their potential role in smooth muscle contraction.

Adult↗
PubMed1982

Effect of prazosin on lipoprotein metabolism in premenopausal, hypertensive women.

Eight premenopausal women with a diastolic blood pressure above 100 mm Hg were treated with prazosin (average dose, 4 mg/day) for 1 year. After 1 month and after 1 year of treatment, serum cholesterol and triglycerides did not differ significantly from pre- and post-treatment values. Nor were any statistically significant alterations found in cholesterol and triglyceride concentrations in the very low density, low density, and high density lipoproteins. The fractional catabolic rate of exogenous triglycerides and the lipoprotein lipase activity in adipose tissue and in skeletal muscle tissue were not affected by the treatment. The data support the view that prazosin therapy does not adversely affect lipoprotein metabolism in premenopausal, healthy, normolipidemic women.

Adipose Tissue↗
PubMed1981

Myocardial infarction in young subjects.

The occurrence of myocardial infarction (MI) in subjects younger than 35 years of age is the subject of this work. The aims were to evaluate the validity of the diagnosis and to study the long-term prognosis for these patients. Through the central data register of all hospital discharges in the Uppsala hospital region (approximately 1.25 mill. inhabitants) 30 patient histories were obtained. They were carefully evaluated and all survivors were invited to an examination at the Department of Cardiology. The follow-up period from the initial hospital stay was up to 11 years. The hospital mortality among 14 subjects with MI and coronary atheromatosis was 29%, increasing to 43% in the follow-up period. Six of the seven investigated survivors in this group were symptom-free and full-time employed. Hyperlipoproteinemia, smoking and heredity for ischemic heart disease seemed to be the most important risk factors among the 14 subjects in this group. Further studies are necessary to evaluate the validity of diagnoses obtained from central data register. In ten patients the initial diagnosis had been incorrect.

Adult↗
PubMed1980

Findings at a re-examination of a self-administered questionnaire after two and a half years in a sample of sixty-year-old men.

The result of examinations conducted by self-administered questionnaire on two occasions almost three years apart in the same sample of men in their sixties is related. An overall consistency of 87% was found, but the proportion of changed answers differed from 7 to 26% among the nine sections of the questionnaire, the highest rate of change occurring in the section on physical habits. Most changes could be anticipated among men in their seventh decade, the rise in knowledge about cardiovascular diseases among relatives being an exception.

Follow-Up Studies↗
PubMed1979

Once-daily metoprolol in primary hypertension.

The antihypertensive effect of the selective beta-1-adrenoceptor blocker, metoprolol, administered once daily was evaluated in 32 patients with primary hypertension. After a 4-wk placebo period, the patients were treated with either 150 mg or 300 mg of metoprolol, once daily, for 8 wk. Initially and during the treatment periods blood was drawn for analysis of metoprolol in plasma, plasma renin activity (PRA), and electrolytes, and urine was collected for determination of the urinary aldosterone excretion. Metoprolol reduced the blood pressure measured up to 26 hr after the last dose. The percentage of responders to metoprolol (decrease of mean arterial pressure greater than or equal to 10% over placebo) was 40% for patients on 150 mg and 71% for patients on 300 mg. Except in the standing position, heart rates were reduced for 26 hr after a 150-mg dose. There was a correlation between pretreatment PRA levels and antihypertensive effect of metoprolol in patients on 300 mg metoprolol but not in patients on 150 mg. Urinary aldosterone decreased equally during treatment in responders and nonresponders. Antihypertensive effects and side effects did not correlate with plasma metoprolol concentrations.

Adult↗
PubMed1979

Comparison of glucose tolerance, serum insulin, serum lipids and skinfold thickness between 50- and 60-year-old men.

Two apparently healthy male groups, one 60 (n = 67) and one 50 (n = 367) years of age were compared with respect to blood glucose, serum lipid and serum insulin concentration and intravenous glucose tolerance. These groups were recruited from two health surveys performed on male populations of these ages in the municipality of Uppsala. The prevalence of diabetes mellitus in the two health survey populations were 4.5% and 0.9%, respectively. No significant differences in serum triglycerides, serum cholestrol and fasting serum insulin concentrations were found between the two age groups. Significantly higher k-values and higher early serum insulin response to i.v. glucose were found in the younger than in the older age group. The older age group was more obese, than the younger group. It is concluded that the prevalence of diabetes increases considerably in males between 50 and 60 years of age. In parallel, the prevalence of decreased glucose tolerance is increasing, which might partly be explained by increased body weight and partly by an impaired pancreatic beta-cell function.

Adipose Tissue↗
PubMed1979

Blood pressure in 60-year-old men. Findings in a health survey and some comparisons with 50-year-old men in the same community.

A population survey of 60-year-old men (n=331) was performed in Uppsala. tthe prevalence of hypertension defined as established hypertension and those having an unknown diastolic blood pressure (DBP) of greater than or equal to 105 mmHg was 19.3%. Of the hypertensive population, 35.9% had not been detected previously. In the treated group, 43.9% were poorly controlled regarding the BP level. Thus 64.1% of the total hypertensive population at the age of 60 years were either undetected or inadequately controlled. Excretion of urinary electrolytes was also evaluated in this work. All participants of the health survey except four performed a 24-hour collection of urine following the health examination. Care was taken with endogenous creatinine clearance. Negative and significant correlations were noted between excretion of sodium and potassium in urine and DBP levels in the group (n=23) of untreated hypertensives. In a population sample (n=135) of healthy subjects devoid of medical treatment in the same population survey, a positive and significant correlation was noted between the systolic BP and the urinary excretion of sodium. Thus up to a certain BP level there is a pressure diuresis and at higher BP levels the kidney retains electrolytes.

Blood Pressure↗
PubMed1978

Lipoprotein-lipase activity in subcutaneous, adipose tissue in healthy subjects: variation of activity in a population of 60-year-old men.

The lipoprotein-lipase activity (LPLA) in the abdominal, subcutaneous, adipose tissue was studied in a random sample (n = 69) of 60-year-old men. A new method for the quantification of LPLA was applied. The mean value was 67 mU/g when expressed per gram (wet weight) of adipose tissue. Several subjects within the lower part of the range of adipose-tissue LPLA values had low concentrations of serum-triglycerides (S-TG). There was no correlation between the LPLA and S-TG concentrations in the fasting state. Among the 69 subjects, four had newly detected diabetes mellitus and had significantly lower LPLA in the adipose tissue than the control group. The fat-cell size and the LPLA per gram of adipose tissue were not correlated. Thus, obesity without diabetes mellitus does not imply a low LPLA concentration in adipose tissue. The variation of the concentration of adipose-tissue LPLA in the fasting state in this population was explained only to a minor extent by the variation of S-insulin and blood-glucose parameters, when analysed statistically by a stepwise multiple-regression technique.

Abdominal Muscles↗
PubMed1978

Health and disease at the age of sixty. Findings in a health survey of 60-year-old men in Uppsala and a comparison with men 10 years younger.

A health investigation was performed among 331 men aged 60 years in Uppsala. The investigation was performed in the same way as in 50-year-old men (n = 2322) in the same community, previously described. Thus it was possible to make certain comparisons between these two populations of middle-aged men. A considerably higher morbidity, given as point prevalence, was found for diseases of the cardiovascular system and of the endocrine organs, in the older population compared with the younger. Parallel to this a higher consumption of pharmaceuticals was reported by the older men. Only 39% among the older men versus 51% of the younger men were smokers. Nearly the same number (two-thirds) of men in both age groups were without codable ECG abnormalities in their resting ECG. Among the older men, however, there were more subjects having multiple pathological ECG findings than in the younger age group. It is concluded that it is possible to reach approximately 80% of the actual population in special health investigations, in middle-aged men. Future studies, preferably in younger subjects, should aim at an early detection and primary prevention of cardiovascular and endocrine diseases.

Age Factors↗
PubMed1976

What middle-aged men know of their parents' cause of death and age at death. A comparison between history and death certificate.

Middle-aged men's knowledge of the circumstances of their parents' diseases and death is reliable to such an extent that it can be used when appropriate for therapeutic purposes in familial diseases. This conclusion is based on findings in a health examination survey of 441 middle-aged men in Uppsala, Sweden where the men were asked whether their parents were dead and, if so, the known cause of death and at what age they had died. The information reported was then compared with the official data kept by the authorities. In 87% of cases it was possible to perform such a comparison. The study showed good conformity of the two sources, in general.

Accidents↗