Biomedical subjects

U Wedding

Publications and source records attributed to U Wedding.

21 records · Page 2Linked to original sources

PubMed2000

[Geriatric oncology].

The demographic development will result in a major increase in the number of elderly cancer patients. Age is the main risk factor for the development of a malignant disease. The incidence of the main cancer diagnosis increases with advancing age. Treatment of elderly cancer patients is an exquisite task. On the one hand, an increased morbidity and mortality may be the result of an unreflected transfer into the geriatric setting of treatment schedules developed for younger patients. On the other hand, reduction of dose intensity can result in decreased survival, life prolongation or insufficient palliation. Elderly people are a very heterogeneous group. Some are in a very good health status. Others are impaired, dependent, suffer from a number of comorbidities and have to take a variety of drugs. Those conditions and not the chronological age influence tolerance against tumour therapy. For elderly patients maintenance of independence and quality of life is more important than disease free survival and prolongation of life.

Aged↗

PubMed1997

Clinical stable systemic mastocytosis with interferon alpha-2b therapy.

Systemic mastocytosis (SM) with progressive infiltration of various organs by mast cells is a rare disease with a mean survival of 2 years. So far there is no established therapy. We describe a patient with progressive mastocytosis who had a clinical response to interferon alpha-2b 3 x 5 Mio U s.c. three times a week. The response is stable 3 years after initiation of therapy and includes reduction of abdominal lymphadenopathy, ascites, decrease of serum and urinary histamine levels as well as pulmonary reticulonodular markings.

Antineoplastic Agents↗

PubMed1996

Rapid onset of apoptosis in vitro follows disruption of beta 1-integrin/matrix interactions in human colonic crypt cells.

BACKGROUND & AIMS: Apoptosis by loss of adherence is a recently described phenomenon termed "anoikis." beta 1, integrins are heterodimeric surface molecules mediating adhesion to the extracellular matrix. The aim of this study was to address whether anoikis accounts for the elimination of senescent enterocytes and, if so, whether beta 1 integrins are involved. METHODS: Whole crypts were isolated from normal human colonic mucosa and examined in vitro. RESULTS: The vast majority of cells in resuspended crypts rapidly underwent apoptosis within 4 hours. Apoptosis was partially inhibited when cells had contact with collagen I-coated membranes or when whole crypts were embedded in a collagen gel. Preincubation of crypts with an inhibiting anti-beta 1 antibody before readhesion caused a much higher apoptotic rate. Confocal microscopy of embedded crypts revealed two critical zones of high sensitivity to temporary loss of adherence: the base of the crypts where stem cells are supposed to reside and the crypt mouth including the surface epithelium. CONCLUSIONS: Survival of colonic epithelia crucially depends on matrix adhesion and is likely to be guaranteed by beta 1-integrin/ matrix interaction. The data strongly suggest that anoikis is the way senescent colon cells die.

Apoptosis↗