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Biomedical subjects

U Wemmer

Publications and source records attributed to U Wemmer.

At least 19 recordsLinked to original sources
PubMed1990

[52d Cologne Dermatology Meeting of the Cologne University Dermatology Clinic 24 January 1990].

Patients with the following diagnoses were presented: pyoderma gangraenosum in a patient with myelodysplastic syndrome passing into an acute myelomonocytic leukemia and specific cutaneous infiltration, primary genital infection with herpes simplex virus, type 1 (HSV-1) in an adult patient, pellagroid, Sweet's syndrome with follicular involvement, Sweet's syndrome in a patient with cancer of the breast, lichen amyloidosus, angiolymphoid hyperplasia with eosinophilia, Darier's disease 1. associated with basal cell carcinoma 2. with specific cutaneous infiltrations in a patient with acute myeloid leukemia, body building, anabolic steroids and fertility, multiple trichodiscomas and perifollicular fibromas, Buschke's scleroedema adultorum, extensive necrobiosis lipoidica without diabetes mellitus, extramammary, multifocal type of Paget's disease.

Dermatology↗
PubMed1989

[Optimized interval treatment of eczema with fluprednidene. A multicenter double-blind study].

In a multicenter double-blind study, 44 patients suffering from eczema were bilaterally treated with 0.1% fluprednidene-21-acetate over 21 days. Continuous application twice a day was compared with intermittent therapy, i.e. 1 day intermission (15 patients), 2 days intermission (16 patients) and 3 days intermission (13 patients) using the cream base. Final evaluation was based on 11 criteria. All regimens, continuous and intermittent, proved effective (at least 90% reduction of the lesions). Treatment with 3 days intermission showed the same favorable results as continuous application, although the amount of glucocorticoids applied was 75% less. Measurements of the skin fold thickness (SFT) in healthy controls did not indicate any atrophy after treatment with fluprednidene under the same conditions as the eczema patients or under occlusion for up to 21 days. Clobetasol-17-propionate, in contrast, significantly reduced the SFT already after application of only 1 week.

Administration, Topical↗
PubMed1989

[Aseptic skin necrosis after subcutaneous injection of alpha interferon].

Aseptic necrosis of the skin developed in two patients with HIV-associated disseminated Kaposi's sarcoma after subcutaneous injection of recombinant interferon-alpha. Both patients were given it at a daily dosage of 20 x 10(6) IU/m2 body surface area. One of the patients, after full remission had been achieved, received a reduced dosage of 3 x 10(6) IU/m2, twice weekly. The clinical picture and course of the changes were similar to those of embolia cutis medicamentosa (Nicolau's syndrome), which can occur after injection of various drugs, intended to be intramuscular but by mistake given intra-arterially.

Acquired Immunodeficiency Syndrome↗
PubMed1988

[Hypereosinophilia syndrome--successful PUVA therapy].

A 71-year-old female patient with monosymptomatic hypereosinophilic syndrome is presented. Other dermatological and internal diseases associated with eosinophilia were excluded. The patient had an excellent response to photochemotherapy (PUVA).

Aged↗
PubMed1986

[Psoriasis in HTLV-III-induced immunologic defect--status of cellular immunity and immunohistologic findings].

Four patients suffering from immune deficiency related to HTLV III developed psoriasis vulgaris. All patients showed lymphadenopathy and cutaneous hypergy or anergy. In three of them, the count of peripheral helper cells was critically decreased (less than 400/microliter), and they showed oral candidosis. One patient suffered from disseminated Kaposi's sarcoma and developed pneumocystis carinii pneumonia. The psoriasis was extensive, exsudative, and almost refractory to therapeutical approaches. The bulk of dermal infiltrating mononuclear cells were T lymphocytes, mostly the T 8 positive phenotype. The majority of these cells were HLA-DR positive, so were many epidermal cells. OKT6 positive epidermal Langerhans' cells were not diminished. Thus we observed the development of psoriasis in spite of severe disturbances of cellular immunity. We suppose that immune mechanisms mediated by T cells--after having got out of control--might play some role in the pathogenesis of the disease.

Acquired Immunodeficiency Syndrome↗
PubMed1986

[Effect of various kinds of tar and tar concentrations on anthralin erythema].

The effect of tar on anthralin-induced erythema was epicutaneously tested in ten patients. 3%, 5%, or 10% crude coal tar or coal tar solution was added to vaseline containing anthralin. A 5% or 10% tar preparation significantly suppressed the anthralin erythema induced by 0.5 to 1.0% anthralin having been applied for 24 hrs. In these concentrations, coal tar solution was at least as effective as coal tar itself.

Adolescent↗
PubMed1984

[Croup syndrome and harmful agents in respiratory air. A statistical analysis of seasonal fluctuations of emission values in relation to the incidence of disease].

Between 1971 and 1983 admissions with croup syndrome to two hospitals for children were recorded. During this time 1926 patients were hospitalized in Mannheim and 661 patients in Darmstadt. Air pollution by SO2, NO2, NO, CO, O3 and dust were measured. In Darmstadt no correlation was found between croup and air pollution, while in Mannheim, monthly averages of SO2, NO2, NO and CO showed linear correlations with monthly cases of croup.

Air Pollution↗
PubMed1981

[Ultrasonics in the differential diagnosis of space-occupying lesions of the kidney in children].

During the last few years the coordination of ultrasound, radiology and urologic surgery led to the diagnosis and treatment of numerous diseases of the kidney. From 1976 till the beginning of 1979 we were able to diagnose 50 expanding retroperitoneal processes. These were hydronephroses, malignant tumors and enlargement of the kidney due to inflammatory affections ensuing nephrolithiasis as well as urosepsis and shock. The fact that sonography is a harmless, non invasive, simple and often repeatable examination is the most important advantage. Provided that ultrasound diagnosing is performed by an experienced person, there is a good correlation to the common x-ray methods and specially recommended for postoperative controls.

Child↗
PubMed1980

[Diagnosis of cholestasis in acute viral hepatitis in childhood (author's transl)].

Over a period of three years all children with acute viral hepatitis (n = 167) were examined for the presence of the abnormal lipoprotein X(LPX). Positive results could be found in 96% of patients with hepatitis A and in 82% of hepatitis B. A good correlation of LPX was ascertained with cholesterol, triglycerides, phospholipids, bilirubin, gamma-glutamyl transferase, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and immunoglobulin M. Control after 29 days in hepatitis A and 46 days in hepatitis B showed absence of LPX and normal pattern of lipoprotein-electrophoresis. Enzyme activities were slightly elevated, lipids and immunoglobulin M remained above upper normal range. In acute phase of viral hepatitis lipoprotein X is the most specific test in determining the presence of cholestasis, but in views on course of disease serum-lipids and immunoglobulin M have a similar sensitivity like enzyme patterns.

Adolescent↗
PubMed1979

[Balanced parenteral and oral feeding of underweight newborn infants].

The oral feeding of 50 newborns with low birth weight was combined with infusions of two different amino acid solutions (mother milk-adapted and requirement-adapted), parenteral lipids and glucose. All infants showed a rapid weight gain, the N-balance became positive, hypoglycemic or hyperosmotic reactions were missing. Amino acid imbalances could not be seen, values of glutamic acid, aspartic acid and asparagine differed in both groups just as proline. In management of infants with low birth weight the supplemental application of these amino acid solutions, lipids and glucose has advantages.

Administration, Oral↗
PubMed1978

[Cranial metaphysial dysplasia (Jackson) (author's transl)].

The typical development of the radiological and clinical features of cranial metaphyseal dysplasia were observed over a period of nine years in one patient. This condition is most commonly confused with metaphyseal dysplasia (Pyle), but differs from the latter in showing pronounced changes in the skull leading to blindness, deafness and facial paralysis as well as club-shaped metaphyses. Cranial metaphyseal dysplasia, particularly in its autosomal recessive form, leads to reduced intelligence and life expectancy of the patients. The diagnosis can usually be made in early childhood.

Abnormalities, Multiple↗
PubMed1978

[Differential diagnosis of metaphyseal dysplasias and osteodysplasty (osteodysplasty of Melnick and Needles) (author's transl)].

The article reports on 4 patients with rare modeling defects of the long bones. These defects are metaphyseal dysplasia, craniometaphyseal dysplasia, frontometaphyseal dysplasia, and osteodysplasty (osteodysplasty of Melnick and Needles). The differential diagnostic criteria are shown in a table to allow diagnosis already in children. This appears important in respect of the therapy to be employed (corrective surgery) and for prognosis, as well as for giving patients proper genetic and vocational advice.

Adolescent↗
PubMed1977

[Wilms tumor in hemihypertrophy].

The case of a 4-year-old boy with Wilms' tumor and hemihypertrophy is described. Wilms' tumors are frequently associated with congenital malformations of the urinary tract, with aniridia and hemihypertrophy. Hemihypertrophy is a relatively rare malformation (1:14000) in the common population, but in patients with Wilms' tumors its frequency is about 1:49. Besides Wilms' tumors tumors of the adrenal cortex and hepatoblastomas are frequently observed together with hemihypertrophy.

Arm↗
PubMed1977

[Nutrition of premature infants with human milk and Milupa Meb].

In 45 prematures and small for date-infants weighing more than 1750 g a special formula (Meb) was compared with pooled human milk. Weight gain during feeding human milk occurred more slow that during feeding special formula. This may be due to the different protein- and mineral-intake, while the amounts of calories were similar. Differences of blood-glucose, total bilirubin, beta-cholesterol and of one protein-fraction (alpha-2-globulin) could be statistically as certained. No difference resulted in hemoglobin, red blood cell count, hematocrit, total cholesterol, triglycerides, phospholipids, beta-lipoproteins, transferrin, and protein-electrophoresis. All parameters together suggest, that this special formula for low-birth-weight infants can be used in nutrition of these newborns.

Bilirubin↗
PubMed1977

[Urinary tract infections and abnormalities of the urinary tract in childhood].

The results of an ambulant two-year kidney diagnostic study are compared with those of in-patients from the same period. In 932 intravenous urographies and 616 voiding urethrocystographies the rate of pyelonephritis and vesico-ureteral reflux in girls was significantly higher than in boys (p less than 0.005). Furthermore pyelonephritis was found more often in out-patients (p less than 0.01) than in in-patients. Focal scarring of kidneys occurred in 60% of children with reflux, and only in 6% of those without reflux. The correlation between pyelonephritis and reflux is confirmed. Urinary tract anomalies were seen in 25,8% irregular urographies in 39.3% of our patients. Double kidneys were seen in girls in a statistically higher rate than in boys (p less than 0.05), hydronephrosis and urinary calculi occurred more often in boys (p less than 0.05). Corrective surgery was performed in 71.4% of the children with reflux, follow-up control (54.7%) showed a relaps in no case.

Child↗