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Biomedical subjects

Ulla F Feldt-Rasmussen

Publications and source records attributed to Ulla F Feldt-Rasmussen.

5 recordsLinked to original sources
PubMed2002

[Autoimmune thyroiditis--an infectious disease?].

The aim was to review existing evidence of a possible role of infectious agents in the pathogenesis of autoimmune thyroid disease. Autoimmune thyroid disease is a polygenic, multifactorial disease in which genetically susceptible individuals are exposed to an environmental insult resulting in immune system activation. Different viruses (influenza B, rubella, retrovirus) have been associated with thyroiditis, but no single agent appears to be causative. There is no firm evidence of infection being an important trigger of autoimmune thyroid disease, and it has not been possible to isolate a microorganism neither by culture nor by molecular identification. Infection may be a precipitating factor in the development of autoimmune thyroid disease.

Female↗
PubMed2002

[Localized lipohypertrophy during growth hormone therapy].

Accumulation of subcutaneous fat is described in a 51-year-old woman with panhypopituitarism treated on all insufficient pituitary axes, including growth hormone (GH). Malnutrition and alcoholic liver disease caused reduced synthesis of hepatic insulin-like growth factor I (IGF-I), and the function of IGF-I as biochemical marker of the GH effect was compromised. Peripheral levels of GH and IGF-I in tissues may have reached supra physiological levels and induced localised lipohypertrophy. Adjustment of GH treatment should not rest in all cases on IGF-I alone, but also depend on the clinical effect. Adjustment should follow suspected adverse events, such as lipohypertrophy, which is, however, an unusual complication of GH therapy.

Adipose Tissue↗