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Biomedical subjects

V A Alegre

Publications and source records attributed to V A Alegre.

16 recordsLinked to original sources
PubMed1991

Bullous lesions in cutaneous lupus erythematosus.

Seventeen patients with cutaneous lupus erythematosus (LE) were observed to have bulla formation. Their clinical, histopathologic, and immunopathologic findings are reported. All biopsy specimens studied revealed moderate to severe vacuolating degeneration of the basal cell layer as well as lymphocytic inflammatory infiltrate involving the dermoepidermal junction. Immunoglobulins or C3 (or both) was deposited in the basement membrane zone in eight of nine patients in whom direct immunofluorescence study was performed. We believe that the immune reaction in the papillary dermis and the severe vacuolating degeneration in the basal cell layer result in the separation of epidermis and dermis, and thus bullous formation, in some patients with LE. This phenomenon can be observed not only in systemic LE but also in subacute cutaneous LE and discoid LE.

Adult↗
PubMed1990

Myelofibrosis discovered after diagnosis of Sweet's syndrome.

Multiple edematous plaques and nodules suddenly developed on the face and neck of a 26-year-old man whose physical examination was said to be normal Because the patient's condition fulfilled the diagnostic criteria of Sweet's syndrome, a further general medical examination and hematologic evaluation were performed. Extensive myelofibrosis was revealed by bone marrow biopsy. This case supports the belief that Sweet's syndrome is a reactive phenomenon. Because myelofibrosis was discovered in this patient after Sweet's syndrome was diagnosed, the importance of having the diagnostic criteria of Sweet's syndrome is emphasized. Careful systemic evaluation is indicated, especially when cutaneous lesions are severe or hematologic values are abnormal.

Adult↗
PubMed1989

Histiocytic cytophagic panniculitis.

Nineteen cases of histiocytic cytophagic panniculitis from our institution and from the literature were reviewed for their clinical and histopathologic features. All patients had cutaneous involvement consisting of cutaneous nodules and plaques that occasionally were ecchymotic and ulcerated and were characterized by infiltration of the subcutaneous tissue by large, benign histiocytes with cytophagic features. Thirteen of the patients had died (nine with hemorrhagic complications), four patients had a benign course with remission of the disease, and two patients responded to aggressive polychemotherapy. Immunohistochemical studies of paraffin-embedded tissue, performed in five cases, revealed a large number of infiltrating T cells in the subcutaneous inflammatory lesions.

Adult↗
PubMed1989

Skin lesions associated with circulating lupus anticoagulant.

This retrospective study of 295 patients extends the earlier findings of an association between lupus anticoagulation and thrombosis by demonstrating the occurrence of cutaneous lesions related to the coagulation defect in 70 patients. The most frequent cutaneous associations were thrombophlebitis, skin ulcer, gangrene, haemorrhage, and cutaneous necrosis. Of the patients with skin lesions, 41% had the skin lesion as the first sign of the disease. It is important to recognize this association because nearly 40% of the patients with skin lesions have multisystem thrombotic phenomena in the course of the disease.

Adolescent↗
PubMed1988

Lipomembranous changes in chronic panniculitis.

The clinical and histopathologic findings in 13 patients with lipomembranous changes in the subcutaneous adipose tissue as part of the inflammatory reaction are presented. Nine patients had clinical evidence of vascular disease and four had clinical evidence of connective tissue disease. Histopathologic evidence of endarteritis obliterans, venous stasis, and hemorrhage was present in more than half the patients, and the clinical lesion of liposclerosis was frequently present. These findings suggest that the histologic changes of lipomembranous panniculitis may be the result of an inflammatory reaction in patients who have the liposclerosis of venous insufficiency with connective tissue disease or previous leg ischemia or both.

Adipose Tissue↗
PubMed1988

Histopathologic and immunofluorescence study of skin lesions associated with circulating lupus anticoagulant.

We reviewed the histopathologic findings in 28 specimens from 25 patients who had skin lesions associated with lupus anticoagulant. The clinical lesions were ulcers, gangrene, thrombophlebitis, hemorrhage, and cutaneous necrosis. Noninflammatory thrombosis of small dermal vessels was observed in all 8 biopsy specimens from gangrene lesions, 10 of 13 specimens from ulcer lesions, and 2 of 5 specimens from thrombophlebitis lesions. Necrotizing vasculitis was not significant in these biopsy specimens. Immunofluorescence findings included a positive lupus band test in lupus erythematosus-associated disease and nonspecific deposits in occasional cases. Focal noninflammatory intravascular coagulation is responsible for the microscopic and clinical skin lesions in these patients.

Blood Coagulation Factors↗
PubMed1988

Adult celiac disease, small and medium vessel cutaneous necrotizing vasculitis, and T cell lymphoma.

Cutaneous necrotizing vasculitis of small- and medium-sized vessels developed in a patient with adult celiac disease who later was found to have visceral lymphoma with erythrophagocytosis. Immunologic and genetic probe studies showed the lymphoma to be of T cell differentiation. Celiac disease and T cell lymphoma have been associated previously with the development of cutaneous vasculitis.

Aged↗
PubMed1988

Surface-bound immunoglobulin E on antigen-presenting cells in cutaneous tissue of atopic dermatitis.

Both type I and type IV hypersensitivity reactions have been implicated in the pathogenesis of atopic dermatitis. Using monoclonal antibodies we have identified IgE on the surface of cutaneous dendritic cells in both lesional and nonlesional skin. Double immunofluorescence labeling demonstrates these cells to be antigen-presenting cells. Immunoglobulin E (IgE) was not identified on such cells either in atopic individuals with no history of dermatitis or in patients with a range of other dermatoses. Further studies are consistent with IgE being bound to the cell surface via an Fc-IgE receptor. We conclude that this finding is specific for atopic dermatitis and thus may provide a link between the two types of hypersensitivity reactions frequently observed.

Adolescent↗
PubMed1988

Necrotizing vasculitis and atherosclerosis.

We describe five patients aged 50 years or above who had severe atherosclerosis and necrotizing vasculitis. The vasculitis was seen in the small vessels of four patients and in the medium-sized vessels of one. All five patients had multiple necrotic ulcerative skin lesions, and two underwent amputation. Our cases suggest that the relationship between the two disorders changes and exacerbates the clinical and pathological expression of each disease.

Aged↗
PubMed1986

The simultaneous presence of Langerhans' cell and interdigitating cell antigenic markers on inflammatory dendritic cells.

Immunohistological studies have been performed on tissues from various dermatological conditions using two monoclonal antibodies, RFD1 and NA1/34. These reagents were used to determine whether antigen expression restricted to interdigitating cells (RFD1+) and Langerhans' cells (NA1/34+) in normal tissues might occur together on dendritic cells involved in cutaneous inflammatory reactions. The results presented demonstrate that in psoriasis, allergic contact dermatitis and atopic dermatitis a proportion of the inflammatory dendritic cells express both antigens.

Antigens, Surface↗
PubMedDate not supplied

Cutaneous thrombosis, cerebrovascular thrombosis, and lupus anticoagulant--the Sneddon syndrome. Report of 10 cases.

Ten patients with circulating lupus anticoagulant who presented with cutaneous vascular disease and cerebrovascular disease are presented. Cutaneous manifestations were gangrene, thrombophlebitis, ulcers, and livedo reticularis. All 10 patients had cerebral infarction. The relationship between the cerebral and cutaneous vascular changes and the presence of lupus anticoagulant is supported by a common noninflammatory vascular thrombosis histologically in these patients and by the presence of similar pathologic and clinical findings in patients with the lupus anticoagulant syndrome.

Adult↗