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Biomedical subjects

V A Azizov

Publications and source records attributed to V A Azizov.

13 recordsLinked to original sources
PubMed2003

[Efficacy of combined use of fosinopril and propranolol in acute myocardial infarction].

Echocardiography, Doppler echocardiography and ECG mapping were used in 40 patients aged 30-70 years with first anterior Q-wave myocardial infarction (MI) for the study of effects of combination of fosinopril and propranolol (20 patients) in comparison with propranolol alone (20 patients) on hemodynamics and size of myocardial damage. The use of fosinopril and propranolol was associated with lowering of systolic and diastolic blood pressure without development of hypotension, reduction of sum, number of leads with, and amplitude of ST-segment elevations, and improvement of parameters of left ventricular function. In propranolol treated patients favorable changes of all these parameters were less pronounced. Inhospital clinical course of the disease was also better in patients treated with fosinopril and propranolol.

Adrenergic beta-Antagonists↗
PubMed2003

Immunohistochemical and electron-microscopic characteristics of secretory cardiomyocytes in experimental myocardial infarction.

OBJECTIVE: To study immunohistochemical and electron-microscopic features of secretory cardiomyocytes in experimental myocardial infarction (MI). METHODS: Totally 15 hearts of dogs with experimental MI were studied. For electron-microscopic study materials were collected from left atrium, and its several parts (appendix, lateral and frontal walls). For immunohistochemical analysis of atrial natriuretic factor (ANF) incubation in monoclone immune serum was used (standard monoclonal serum and primary mice antibodies, Immunon). For statistic processing we used Chi-square test (criterion of Pearson agreement). RESULTS: Immunohistochemical and electron-microscopic investigation after 24 hours from experimental myocardial infarction indicated increase of specific activity of secretory cardiomyocytes and after 48 hours decrease of secretion of ANF while cardiomyopathy appears. After 72 hours, blockade of ANF secretion with decompensation of secretory cardiomyocytes occurred. CONCLUSION: Imunohistochemical investigations and analysis of submicroscopic structures of secretory cardiomyocytes after experimental MI showed, that cells were functionally active 24 hours after myocardial infarction with further (48 hours and 72 hours of MI) decrease in amount and impairement of activity.

Animals↗
PubMed2002

[Fungal myocarditis in deep visceral candidiasis].

Morphological and functional changes of the myocardium were studied in 40 patients with candidiasis and attempt to establish morphological criteria of fungal myocarditis was undertaken. Retrospective analysis of autopsy material showed that myocardial involvement in candidiasis was possible and was not as rare as it had been accepted. Clinical symptomatology was not always similar to that of classical infectious-allergic myocarditis. However immunological parameters were characteristic of inflammatory process. Complex echocardiographic study gave important information for assessment of the state of the myocardium.

Adult↗
PubMed1993

[The clinical characteristics of ischemic heart disease in patients with arterial hypertension of different origins].

To study the clinical picture of coronary heart disease with concomitant arterial hypertension of various genesis, 172 patients were examined, out of them the cause of arterial hypertension was hypertensive disease in 54, chronic pyelonephritis in 40, chronic glomerulonephritis in 37, and stenotic atherosclerosis of renal arteries in 29, endocrine disease in 12 patients. The patients were divided into 2 groups: (1) 148 with stenotic atherosclerosis of coronary arteries and (2) 24 patients with intact coronary arteries. Comparison of these patient groups revealed no clear-cut correlation between the age and the detection of exercise-induced angina, as well as the duration of arterial hypertension. There was no correlation between the detection of the anginal syndrome and ECG changes. The incidence of the anginal syndrome was 62.2% in Group 1 and 47.7% in Group 2. It was established that the detection of the anginal syndrome correlated well with the severity of left ventricular hypertrophy and values of blood pressure, despite nosological entities.

Adult↗
PubMed1992

[Transesophageal electrostimulation of the atrium in patients with ischemic heart disease combined with arterial hypertension in disability evaluation ].

The author studied 78 patients (60 males and 18 females) aged 36 to 60 years (mean age 50 +/- 6 years). They all were diagnosed as having coronary heart disease (CHD) concurrent with arterial hypertension. Transesophageal atrial pacing test (TEACT) was positive in 68 (87.2%), and negative in 4 (5.1%) patients. It failed to reach diagnostic ECG criteria in 6 (7.7%) patients. A close relationship was found between the number of diseased coronary arteries and the sensitivity of TEACT. The TEACT parameters were found to be related to bicycle ergometric ones. The findings showed that the threshold rate of induced rhythm decreased when the patients increased their functional class of exercise-induced angina pectoris, the appearance of ST-segment depression being delayed and its disappearance increased. Thus, transesophageal atrial pacing allows the functional class to be defined in patients with CHD concurrent with arterial hypertension from the threshold rate of imposed rhythm and the time of ST-segment depression appearance and disappearance and can be useful both in the diagnosis and appraisal of the working capacity in patients with coronary heart disease concurrent with arterial hypertension.

Adult↗
PubMed1992

[A comparative evaluation of the importance of transesophageal electrical stimulation of the left atrium and of bicycle ergometry in the diagnosis of ischemic heart disease in patients with arterial hypertension].

To make a comparative assessment of transesophageal left atrial pacing (TLAP) and bicycle ergometry (BE) in the diagnosis of coronary heart disease (CHD) in patients with arterial hypertension (AH) of different origin, the authors examined 56 patients. The patients underwent TLAP and selective coronary angiography, of them 39 patients had BE testing. No significant differences were found in their specificity (73 and 78%) and sensitivity (92 and 81%) between TLAP and BE, respectively. The maximum heart rate in CHD patients with AH was significantly higher (130 +/- 6 per min) during TLAP than that in BE (112 +/- 5 per min, p > 0.05), ischemic changes occurring at the same value of double product despite the mode of myocardial ischemia induction in these functional tests (240 +/- 10 and 236 +/- 12 arbitrary units, respectively; p < 0.05). The mean systolic blood pressure was higher in TLAP and in BE (210 +/- 10 and 185 +/- 8 mm Hg). This follows that TLAP and BE finding are comparable and no profound changes occur in TLAP, hence it can be recommended for wide application in the diagnosis of CHD in AH patients.

Adult↗
PubMed1987

[Hemodynamic changes in ischemic heart disease patients undergoing a combined head-down-tilt isometric load].

Hemodynamics and myocardial contractility were examined in 36 male coronary patients and 20 normal subjects at rest, in a 15 degree head-down tilt and during combined antiorthostatic/isometric exercise (AOSIE). Antiorthostatic position was associated with increased stroke and minute volumes, cardiac index in normal subjects, and reduced stroke volume and left ventricular contractility in coronary patients of the 3d-4th functional class. AOSIE produced further increase in left-heart pumping and contractility in normal subjects, and a decrease in stroke and minute volumes, cardiac index and contractility parameters of calibration apex cardiograms in coronary patients of all functional classes. It is concluded that AOSIE can be used for the assessment of left ventricular myocardial function in normal subjects and coronary patients alike.

Adult↗
PubMed1985

[Importance of combined instrumental study methods in the expertise of the work capacity of ischemic heart disease patients with stable stenocardia].

Working capacity of 87 coronary patients with stable angina was assessed on the basis of a functional classification of the results of non-invasive investigations (resting ECG, bicycle ergometry, echocardiography). Bicycle ergometry proved to be the most informative method providing indirect evidence of coronary reserve. An objective assessment of the condition of coronary patients can be made using values of exercise tolerance (threshold capacity and volume of work), heart rate and double product at the peak of exercise. A close correlation exists between the severity of atherosclerotic affection of coronary arteries and individual exercise tolerance, which can be used in the medical evaluation of the working capacity of coronary patients with stable angina pectoris.

Adult↗