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Biomedical subjects

V A Borisov

Publications and source records attributed to V A Borisov.

At least 19 recordsLinked to original sources
PubMed2006

[The experience of diagnosis, treatment and prophylaxis of gastric and duodenal ulcer in outpatient conditions].

Gastric and duodenal ulcer (peptic ulcer) takes the leading place among the pathology of digestive organs. According to the data of specialists from Consulting-and-Diagnostic Center N 52 among the servicemen with chronic diseases the digestive pathology constitutes 32%. Among these diseases the peptic ulcer occurs in 81% cases. Screening esophagogastroduodenoscopy conducted in 1100 servicemen without any complaints aged 22-50 has revealed duodenal ulcer in 5.4%, gastric ulcer--in 0.7% and gastroduodenitis--in 11.4%. With introduction of modern methods of diagnosis, treatment, rehabilitation and prophylaxis of peptic ulcer 98% patients with disease uncomplicated course began and completed treatment in outpatient conditions.

Adult↗
PubMed2001

[Immunosuppressive effects of pathogenic gram-negative bacteria].

The review deals with the Immunosuppressive effects of virulent gram-negative bacteria (Salmonella, Shigela, Pseudomonas aeruginosa), with the importance of these effects for the bacteria to survive in the infected body. The above bacteria affect the immunity system in a different way, yet have common features. They are characterized by the occurrence of endotoxin shock, by the suppression of the phagocytic system and cell-mediated immunity. A significant role in suppressing a cellular immune response is played by the lipopolysaccharide of virulent bacteria that greatly differs from that of nonvirulent strains. The immunosuppressive activity of the bacteria and their lipopolysaccharide is closely related to their virulent properties.

Animals↗
PubMed1997

[Gram-negative virulent bacterial lipopolysaccharide: role in infection and immunity].

The paper discusses the data available in the literature on the studies on lipopolysaccharides (LPS) of bacteria which show their different virulence. A comparative study of the chemical composition and structure of LPS of the bacteria fails to detect any great difference, but they differ in their biological, especially immunobiological properties. It is suggested that the differences are associated with LPS conformation, chiefly its lipid moiety and ion-coordinating processes and free radical reactions are involved in the conformation. Examining just these phenomena may made advances in further studies of virulent bacterial LPS and possibilities of its use while designing new-generation vaccines.

Animals↗
PubMed1996

[Tropical malaria pattern in Russians living in the Republic of Guinea].

Tropical malaria in 188 Russians who have fallen ill in the Republic of Guinea was characterized by an acute onset, high irregular 6-day fever, intoxication, hepatosplenomegaly, moderate of severe forms, high incidence of recurrences. Combination of kinimax with fansidar seemed more effective than routine treatment with chlorochin.

Acute Disease↗
PubMed1989

[Microcirculatory function in various clinical forms of HB and HD viral infections].

Bulbar microphotographic vasography was used in 100 patients with different clinical patterns of HBV and HDV infections to study microcirculation over time. The data obtained were correlated to the data of the immunoassays. The relationship between microcirculatory disorders recordable during HBV and HDV infections and immunopathological responses and conditions occurring in those infections is under discussion.

Acute Disease↗
PubMed1988

[Relation of the immunosuppressivity of virulent Shigella to the structure of O antigen].

The capacity of filtrates of virulent Shigella cultures (VSC) and their different fractions to render avirulent strains, injected intraperitoneally into mice simultaneously with these filtrates, capable of suppressing immune response (delayed hypersensitivity) has been studied. Among the fractions of VSC filtrates, the lipoid fraction soluble in the mixture of ethanol and ether has proved to be active. Active factors can be extracted from VSC filtrates by means of immunosorbents obtained from antibodies of pertinent specificity. VSC filtrates are completely inactivated by treatment with phenol and trichloroacetic acid. These data suggest that the immunosuppressive factors of shigellae, responsible for their capacity to suppress immunological memory, are incorporated into the O-antigen of these bacteria.

Animals↗
PubMed1988

[Microcirculatory function in viral hepatitis A and B].

Microcirculation was studied over time in 51 patients with acute viral hepatitides types A and B using bulbar microphotographic vasography. The results were compared with some immunological indices (the blood level of circulating immune complexes, the platelet aggregation test). The expression of microcirculatory changes correlated both with a type of virus hepatitis and the severity of disease. The relationship of disorders in the system of microcirculation with immune factors, in particular with immunopathological reactions developing during HBV infections, was discussed.

Adolescent↗
PubMed1987

[Shigella toxicity in immunological tolerance].

The toxic effect of killed and live Shigella sonnei cultures on normal mice and on mice, tolerant to Shigella O-antigen and to human erythrocytes of different blood groups (in the ABO system) was under study. The toxicity of shigellae, introduced intraperitoneally, has been found to depend on their viability, on their capacity for penetration into the blood, and on the split character of immunological tolerance to Shigella antigens.

ABO Blood-Group System↗
PubMed1986

[Detection of immunosuppression factors in Shigella sonnei].

A factor, making noninvasive shigellae and other bacteria capable of suppressing immunological memory and secondary immune response manifested as delayed hypersensitivity, has been detected in the germ-free filtrates of the broth cultures of invasive S. sonnei.

Animals↗